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Studies on the Synthesis of Some New 1,2,4-Triazoles Derivatives and Evaluation for their Anti-Tubercular Activity Profiles


Affiliations
1 Mesco College of Pharmacy, Hyderabad (T.S), India
2 Luqman College of Pharmacy, Gulbarga (KA)- 585102, India
     

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The synthesis of new heterocyclic compounds has always drawn the attention of medicinal chemist over the years mainly because they possess diverse biological properties.

The literature survey on 1,2,4-triazoles revealed that they are endowed with wide variety of biological activities. During the present investigation a series of new 1,2,4-triazole derivatives N-(3-(2-(3-hydrazinyl-3-oxoalkanoyl)hydrazinyl)-5(phenoxymethyl)-4H-1,2,4-triazol-4-yl)isonicotinamide(6a-6e) were synthesized by reacting with N-(5-mercapto-3-(phenoxymethyl)-4H-1,2,4-triazol-4-yl)isonicotinamide (5) and aliphatic dicarboxylic acid hydrazides (a-e).

The structures of the newly synthesized compounds were established by FT-IR, 1H-NMR and MASS spectral analysis. All the compounds synthesised 6a to 6e were evaluated for anti-tubercular activity against Mycobacterium tuberculosis H37Rv using MABA method. The compound 6a (n=0) was found to be the most potent anti-tubercular agent. Few of the other compounds in the series also showed significant anti-tubercular properties.


Keywords

1,2,4-Triazole Derivatives, Anti-Tubercular, Mycobacterium tuberculosis.
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  • Studies on the Synthesis of Some New 1,2,4-Triazoles Derivatives and Evaluation for their Anti-Tubercular Activity Profiles

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Authors

Akram
Mesco College of Pharmacy, Hyderabad (T.S), India
Abdul Sayeed
Mesco College of Pharmacy, Hyderabad (T.S), India
Mohd Waseem Akram
Luqman College of Pharmacy, Gulbarga (KA)- 585102, India

Abstract


The synthesis of new heterocyclic compounds has always drawn the attention of medicinal chemist over the years mainly because they possess diverse biological properties.

The literature survey on 1,2,4-triazoles revealed that they are endowed with wide variety of biological activities. During the present investigation a series of new 1,2,4-triazole derivatives N-(3-(2-(3-hydrazinyl-3-oxoalkanoyl)hydrazinyl)-5(phenoxymethyl)-4H-1,2,4-triazol-4-yl)isonicotinamide(6a-6e) were synthesized by reacting with N-(5-mercapto-3-(phenoxymethyl)-4H-1,2,4-triazol-4-yl)isonicotinamide (5) and aliphatic dicarboxylic acid hydrazides (a-e).

The structures of the newly synthesized compounds were established by FT-IR, 1H-NMR and MASS spectral analysis. All the compounds synthesised 6a to 6e were evaluated for anti-tubercular activity against Mycobacterium tuberculosis H37Rv using MABA method. The compound 6a (n=0) was found to be the most potent anti-tubercular agent. Few of the other compounds in the series also showed significant anti-tubercular properties.


Keywords


1,2,4-Triazole Derivatives, Anti-Tubercular, Mycobacterium tuberculosis.

References