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Coadministration of Resveratrol and Rice Oil Mitigates Nociception and Oxidative State in a Mouse Fibromyalgia-like Model


Affiliations
1 Postgraduate Program in Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, 90619-900 Porto Alegre, RS, Brazil
2 Postgraduate Program in Genetics and Applied Toxicology, Lutheran University of Brazil, 92425-900 Canoas, RS, Brazil
3 Postgraduate Program in Health Sciences: Medicine and Biomedicine, Institute of Education and Research, Grupo Santa Casa de Belo Horizonte, 30150-240 Belo Horizonte, MG, Brazil
4 Pontifical Catholic University of Rio Grande do Sul, 90619-900 Porto Alegre, RS, Brazil
 

The mechanism underlying pain symptoms in fibromyalgia (FM) is not fully understood. Oxidative stress has emerged as pathophysiological event occurring during the development of the disease. The present study aimed at investigating the efficacy of resveratrol associated with rice bran oil on fibromyalgia-like mice model. Subcutaneous injection of reserpine (0.25mg/Kg) during 3 days produced fibromyalgia-like symptoms. Resveratrol and/or rice oil or pregabalin were administered through oral route in therapeutic (single dose) and preventive (four doses) schemes. In both schemes, treatment with resveratrol associated with rice bran oil and pregabalin significantly reduced mechanical allodynia and thermal hyperalgesia in animals. The preventive scheme displayed antidepressant effect which was demonstrated by the forced swimming test as well as reduced reactive species in the cerebrospinal fluid of reserpinized animals. Taken together, our data provide evidences that the intake of resveratrol associated with rice bran oil plays antinociceptive and antidepressant actions probably through reducing reactive species and suggests the involvement of oxidative stress in this model of FM as possible underlying mechanism of pathogenesis of the disease.
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  • Coadministration of Resveratrol and Rice Oil Mitigates Nociception and Oxidative State in a Mouse Fibromyalgia-like Model

Abstract Views: 90  |  PDF Views: 3

Authors

Caroline Peres Klein
Postgraduate Program in Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, 90619-900 Porto Alegre, RS, Brazil
Marcos Rodrigues Cintra
Postgraduate Program in Genetics and Applied Toxicology, Lutheran University of Brazil, 92425-900 Canoas, RS, Brazil
Nancy Binda
Postgraduate Program in Health Sciences: Medicine and Biomedicine, Institute of Education and Research, Grupo Santa Casa de Belo Horizonte, 30150-240 Belo Horizonte, MG, Brazil
Danuza Montijo Diniz
Postgraduate Program in Health Sciences: Medicine and Biomedicine, Institute of Education and Research, Grupo Santa Casa de Belo Horizonte, 30150-240 Belo Horizonte, MG, Brazil
Marcus Vinicius Gomez
Postgraduate Program in Health Sciences: Medicine and Biomedicine, Institute of Education and Research, Grupo Santa Casa de Belo Horizonte, 30150-240 Belo Horizonte, MG, Brazil
Andre Arigony Souto
Pontifical Catholic University of Rio Grande do Sul, 90619-900 Porto Alegre, RS, Brazil
Alessandra Hubner de Souza
Postgraduate Program in Genetics and Applied Toxicology, Lutheran University of Brazil, 92425-900 Canoas, RS, Brazil

Abstract


The mechanism underlying pain symptoms in fibromyalgia (FM) is not fully understood. Oxidative stress has emerged as pathophysiological event occurring during the development of the disease. The present study aimed at investigating the efficacy of resveratrol associated with rice bran oil on fibromyalgia-like mice model. Subcutaneous injection of reserpine (0.25mg/Kg) during 3 days produced fibromyalgia-like symptoms. Resveratrol and/or rice oil or pregabalin were administered through oral route in therapeutic (single dose) and preventive (four doses) schemes. In both schemes, treatment with resveratrol associated with rice bran oil and pregabalin significantly reduced mechanical allodynia and thermal hyperalgesia in animals. The preventive scheme displayed antidepressant effect which was demonstrated by the forced swimming test as well as reduced reactive species in the cerebrospinal fluid of reserpinized animals. Taken together, our data provide evidences that the intake of resveratrol associated with rice bran oil plays antinociceptive and antidepressant actions probably through reducing reactive species and suggests the involvement of oxidative stress in this model of FM as possible underlying mechanism of pathogenesis of the disease.