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Relationship between Neuropathic Pain and Obesity


Affiliations
1 Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo 113-8655, Japan
2 Department of Pain and Palliative Medicine,The University of Tokyo Hospital, Tokyo 113-8655, Japan
3 Department of Orthopaedic Surgery, The University of Tokyo Hospital, Tokyo 113-8655, Japan
4 Department of Orthopaedic Surgery, The University of Tokyo Hospital, Tokyo 113-8655
5 Department of Orthopaedic Surgery, Jichi University, Graduate School of Medicine, Tochigi, Japan
 

Objectives: Overweight negatively affects musculoskeletal health; hence obesity is considered a risk factor for osteoarthritis and chronic low back pain. This was conducted to determine if obesity affects neuropathic pain, usually considered unrelated to the weight-load on themusculoskeletal system. Methods: Using a cut-off bodymass index value of 25, 44 patients with neuropathic pain were grouped into a "high-BMI" group and a "normal-BMI" group. Results: The numeric rating scale of the high-BMI group was significantly higher than that of the normal-weight group (P < 0.05). The total NPSI scores were significantly higher (P <0.01), and the paroxysmal pain and the negative symptoms were more serious in the high-BMI group than in the normal-BMI group. The high-BMI subjects also had significantly higher SF-MPQ scores (P <0.05).However, both physical and mental health status on the SF-36 were comparable between the groups. Discussion: Neuropathic pain that did not arise from musculoskeletal damage was higher in the high-BMI patients. Paroxysmal pain was more severe, suggesting that neural damage might be aggravated by obesity-associated inflammation.These findings should have needed to be confirmed in future studies.
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  • Relationship between Neuropathic Pain and Obesity

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Authors

Jun Hozumi
Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo 113-8655, Japan
Masahiko Sumitani
Department of Pain and Palliative Medicine,The University of Tokyo Hospital, Tokyo 113-8655, Japan
Yoshitaka Matsubayashi
Department of Orthopaedic Surgery, The University of Tokyo Hospital, Tokyo 113-8655, Japan
Hiroaki Abe
Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo 113-8655, Japan
Yasushi Oshima
Department of Orthopaedic Surgery, The University of Tokyo Hospital, Tokyo 113-8655, Japan
Hirotaka Chikuda
Department of Orthopaedic Surgery, The University of Tokyo Hospital, Tokyo 113-8655
Katsushi Takeshita
Department of Orthopaedic Surgery, Jichi University, Graduate School of Medicine, Tochigi, Japan
Yoshitsugu Yamada
Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo 113-8655, Japan

Abstract


Objectives: Overweight negatively affects musculoskeletal health; hence obesity is considered a risk factor for osteoarthritis and chronic low back pain. This was conducted to determine if obesity affects neuropathic pain, usually considered unrelated to the weight-load on themusculoskeletal system. Methods: Using a cut-off bodymass index value of 25, 44 patients with neuropathic pain were grouped into a "high-BMI" group and a "normal-BMI" group. Results: The numeric rating scale of the high-BMI group was significantly higher than that of the normal-weight group (P < 0.05). The total NPSI scores were significantly higher (P <0.01), and the paroxysmal pain and the negative symptoms were more serious in the high-BMI group than in the normal-BMI group. The high-BMI subjects also had significantly higher SF-MPQ scores (P <0.05).However, both physical and mental health status on the SF-36 were comparable between the groups. Discussion: Neuropathic pain that did not arise from musculoskeletal damage was higher in the high-BMI patients. Paroxysmal pain was more severe, suggesting that neural damage might be aggravated by obesity-associated inflammation.These findings should have needed to be confirmed in future studies.