Open Access Open Access  Restricted Access Subscription Access

Liver Cirrhosis and Diabetes Mellitus Are Risk Factors for Staphylococcus aureus Infection in Patients with Healthcare-Associated or Hospital-Acquired Pneumonia


Affiliations
1 Division of Pulmonary, Critical Care and Sleep Medicine, Chang Gung Memorial Hospital, 222 Maijin Road, Anle District, Keelung 20401, Taiwan, Province of China
 

Background: The risk factors for Staphylococcus aureus (S. aureus) pneumonia are not fully identified. The aim of this work was to find out the clinical characteristics associated with S. aureus infection in patients with Health Care-Associated Pneumonia (HCAP) and Hospital-Acquired Pneumonia (HAP), which may be applicable for more appropriate selection of empiric antibiotic therapy. Methods: From July 2007 to June 2010, patients who were admitted to the intensive care unit with severe HCAP/HAP and severe sepsis were enrolled in this study. Lower respiratory tract sample was semi quantitatively cultured. Initial broad-spectrum antibiotics were chosen by Taiwan or American guidelines for pneumonia management. Standard bundle therapies were provided to all patients according to the guidelines of the Surviving Sepsis Campaign. Results: The most frequently isolated pathogens were Pseudomonas aeruginosa, S. aureus, Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli. Patients with positive isolation of S. aureus in culture had significantly higher history of liver cirrhosis and diabetes mellitus, with odds ratios of 3.098 and 1.899, respectively. The S. aureus pneumonia was not correlated with history of chronic obstructive pulmonary disease, hypertension, and hemodialysis. Conclusion: Liver cirrhosis and diabetes mellitus may be risk factors for S. aureus infection in patients with severe HCAP or HAP.
User
Notifications
Font Size

Abstract Views: 81

PDF Views: 0




  • Liver Cirrhosis and Diabetes Mellitus Are Risk Factors for Staphylococcus aureus Infection in Patients with Healthcare-Associated or Hospital-Acquired Pneumonia

Abstract Views: 81  |  PDF Views: 0

Authors

Huang-Pin Wu
Division of Pulmonary, Critical Care and Sleep Medicine, Chang Gung Memorial Hospital, 222 Maijin Road, Anle District, Keelung 20401, Taiwan, Province of China
Chien-Ming Chu
Division of Pulmonary, Critical Care and Sleep Medicine, Chang Gung Memorial Hospital, 222 Maijin Road, Anle District, Keelung 20401, Taiwan, Province of China
Chun-Yao Lin
Division of Pulmonary, Critical Care and Sleep Medicine, Chang Gung Memorial Hospital, 222 Maijin Road, Anle District, Keelung 20401, Taiwan, Province of China
Chung-Chieh Yu
Division of Pulmonary, Critical Care and Sleep Medicine, Chang Gung Memorial Hospital, 222 Maijin Road, Anle District, Keelung 20401, Taiwan, Province of China
Chung-Ching Hua
Division of Pulmonary, Critical Care and Sleep Medicine, Chang Gung Memorial Hospital, 222 Maijin Road, Anle District, Keelung 20401, Taiwan, Province of China
Teng-Jen Yu
Division of Pulmonary, Critical Care and Sleep Medicine, Chang Gung Memorial Hospital, 222 Maijin Road, Anle District, Keelung 20401, Taiwan, Province of China
Yu-Chih Liu
Division of Pulmonary, Critical Care and Sleep Medicine, Chang Gung Memorial Hospital, 222 Maijin Road, Anle District, Keelung 20401, Taiwan, Province of China

Abstract


Background: The risk factors for Staphylococcus aureus (S. aureus) pneumonia are not fully identified. The aim of this work was to find out the clinical characteristics associated with S. aureus infection in patients with Health Care-Associated Pneumonia (HCAP) and Hospital-Acquired Pneumonia (HAP), which may be applicable for more appropriate selection of empiric antibiotic therapy. Methods: From July 2007 to June 2010, patients who were admitted to the intensive care unit with severe HCAP/HAP and severe sepsis were enrolled in this study. Lower respiratory tract sample was semi quantitatively cultured. Initial broad-spectrum antibiotics were chosen by Taiwan or American guidelines for pneumonia management. Standard bundle therapies were provided to all patients according to the guidelines of the Surviving Sepsis Campaign. Results: The most frequently isolated pathogens were Pseudomonas aeruginosa, S. aureus, Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli. Patients with positive isolation of S. aureus in culture had significantly higher history of liver cirrhosis and diabetes mellitus, with odds ratios of 3.098 and 1.899, respectively. The S. aureus pneumonia was not correlated with history of chronic obstructive pulmonary disease, hypertension, and hemodialysis. Conclusion: Liver cirrhosis and diabetes mellitus may be risk factors for S. aureus infection in patients with severe HCAP or HAP.