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Quantitative EEG and Cognitive Decline in Parkinson’s Disease


Affiliations
1 Universitatsspital Basel, Abteilung Neurophysiologie, Petersgraben 4, 4031 Basel, Switzerland
 

Cognitive decline is common with the progression of Parkinson’s disease (PD). Different candidate biomarkers are currently studied for the risk of dementia in PD. Several studies have shown that quantitative EEG (QEEG) is a promising predictor of PD-related cognitive decline. In this paper we briefly outline the basics of QEEG analysis and analyze the recent publications addressing the predictive value of QEEG in the context of cognitive decline in PD. The MEDLINE database was searched for relevant publications from January 01, 2005, to March 02, 2015. Twenty-four studies reported QEEG findings in various cognitive states in PD. Spectral and connectivity markers of QEEG could help to discriminate between PD patients with different level of cognitive decline. QEEG variables correlate with tools for cognitive assessment over time and are associated with significant hazard ratios to predict PD-related dementia. QEEG analysis shows high test-retest reliability and avoids learning effects associated with some neuropsychological testing; it is noninvasive and relatively easy to repeat.
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  • Quantitative EEG and Cognitive Decline in Parkinson’s Disease

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Authors

Vitalii V. Cozac
Universitatsspital Basel, Abteilung Neurophysiologie, Petersgraben 4, 4031 Basel, Switzerland
Ute Gschwandtner
Universitatsspital Basel, Abteilung Neurophysiologie, Petersgraben 4, 4031 Basel, Switzerland
Florian Hatz
Universitatsspital Basel, Abteilung Neurophysiologie, Petersgraben 4, 4031 Basel, Switzerland
Martin Hardmeier
Universitatsspital Basel, Abteilung Neurophysiologie, Petersgraben 4, 4031 Basel, Switzerland
Stephan Ruegg
Universitatsspital Basel, Abteilung Neurophysiologie, Petersgraben 4, 4031 Basel, Switzerland
Peter Fuhr
Universitatsspital Basel, Abteilung Neurophysiologie, Petersgraben 4, 4031 Basel, Switzerland

Abstract


Cognitive decline is common with the progression of Parkinson’s disease (PD). Different candidate biomarkers are currently studied for the risk of dementia in PD. Several studies have shown that quantitative EEG (QEEG) is a promising predictor of PD-related cognitive decline. In this paper we briefly outline the basics of QEEG analysis and analyze the recent publications addressing the predictive value of QEEG in the context of cognitive decline in PD. The MEDLINE database was searched for relevant publications from January 01, 2005, to March 02, 2015. Twenty-four studies reported QEEG findings in various cognitive states in PD. Spectral and connectivity markers of QEEG could help to discriminate between PD patients with different level of cognitive decline. QEEG variables correlate with tools for cognitive assessment over time and are associated with significant hazard ratios to predict PD-related dementia. QEEG analysis shows high test-retest reliability and avoids learning effects associated with some neuropsychological testing; it is noninvasive and relatively easy to repeat.