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Remineralization of Incipient Lesions with Anticariogenic Casein Phosphopeptides and Fluoride: A Vivo Study


Affiliations
1 Department of Pedodontics and Preventive Dentistry, K.D. Dental College and Hospital, Mathura, Kota – 281121, Uttar Pradesh, India
2 Department of Pedodontics and Preventive Dentistry, K.D. Dental College and Hospital, Mathura, Kota - 281121, Uttar Pradesh, India
3 Department of Pedodontics and Preventive Dentistry, Manipal College of Dental Sciences, Manipal – 576104, Karnataka, India
     

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Objective: The aim of this study was to evaluate the remineralization of incipient lesions with CPP-ACP and its comparison with the effect of fluoride on the same. Study Design: A total of 225 teeth with incipient lesions in 108 children within the age group of 6-14 yrs. were divided into five groups by block randomization. Enamel biopsy was done for incipient lesions. Calcium and phosphate were analyzed using auto analyzer, fluoride was assessed using Orion analyzer. Results: Results showed that CPP-ACP enhances the remineralization process and that CPP-ACP has comparable effect as fluoridated dentifrice, as difference was not statistically significant (p>0.05), using ANOVA, Tukey’s test. Conclusion: CPP-ACP is effective remineralizing agent. A beneficial dose response effect is seen with the application of casein phosphopeptides. In addition, there is a synergistic effect of CPP-ACP with fluoride.


Keywords

CPP-ACP, Fluoride, Remineralization.
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  • Remineralization of Incipient Lesions with Anticariogenic Casein Phosphopeptides and Fluoride: A Vivo Study

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Authors

Ritu Khanduja
Department of Pedodontics and Preventive Dentistry, K.D. Dental College and Hospital, Mathura, Kota – 281121, Uttar Pradesh, India
Rupanjali Verma
Department of Pedodontics and Preventive Dentistry, K.D. Dental College and Hospital, Mathura, Kota - 281121, Uttar Pradesh, India
Shobha Tandon
Department of Pedodontics and Preventive Dentistry, Manipal College of Dental Sciences, Manipal – 576104, Karnataka, India

Abstract


Objective: The aim of this study was to evaluate the remineralization of incipient lesions with CPP-ACP and its comparison with the effect of fluoride on the same. Study Design: A total of 225 teeth with incipient lesions in 108 children within the age group of 6-14 yrs. were divided into five groups by block randomization. Enamel biopsy was done for incipient lesions. Calcium and phosphate were analyzed using auto analyzer, fluoride was assessed using Orion analyzer. Results: Results showed that CPP-ACP enhances the remineralization process and that CPP-ACP has comparable effect as fluoridated dentifrice, as difference was not statistically significant (p>0.05), using ANOVA, Tukey’s test. Conclusion: CPP-ACP is effective remineralizing agent. A beneficial dose response effect is seen with the application of casein phosphopeptides. In addition, there is a synergistic effect of CPP-ACP with fluoride.


Keywords


CPP-ACP, Fluoride, Remineralization.

References