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Arinta, Yukko
- Mangosteen Peel Extract (Garcinia mangostana L.) and its Constituents to Lower Lipid Content on Adipogenesis Cells Model (3T3-L1)
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PDF Views:189
Authors
Wahyu Widowati
1,
Lusiana Darsono
1,
Jo Suherman
1,
Ervi Afifah
2,
Rizal Rizal
2,
Yukko Arinta
2,
Rismawati Laila Qodariah
2,
Tjandrawati Mozef
3,
Tri Suciati
4
Affiliations
1 Maranatha Christian University, Bandung - 40164, ID
2 Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung - 40163, ID
3 Research Center for Chemistry, Indonesian Institute of Sciences, Bandung, West Java, ID
4 Bandung Institute of Technology, Bandung, West Java, ID
1 Maranatha Christian University, Bandung - 40164, ID
2 Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung - 40163, ID
3 Research Center for Chemistry, Indonesian Institute of Sciences, Bandung, West Java, ID
4 Bandung Institute of Technology, Bandung, West Java, ID
Source
Journal of Natural Remedies, Vol 18, No 2 (2018), Pagination: 41-48Abstract
Obesity is one of the risk factor for dyslipidemia incident, cancer, diabetes mellitus, and cardiovascular disease. Treatment of obesity using common commercial drugs shows low rate of success, hence natural products may provide better or more efficient therapeutic approach. Mangosteen (Garcinia mangostana L.) (Clusiaceae) peel extract contains xanthones and it is potentially used as alternative medicine for obesity. This research was done to determine the anti-obesity characteristics of Mangosteen Peel Extract (MPE) and its xanthones α-Mangostin (AM) and γ-Mangostin (GM) on 3T3L1 cell line. Anti-obesity effects of MPE and xanthones were investigated using differentiated-3T3L1 preadipocyte cells. Inhibitory activity of the extract and compounds on the production of Triglyceride (TG), Cholesterol (CHOL), Glucose-6-Phosphate Dehydrogenase (G6PDH) activity, and lipid droplets were examined. MPE and its compound were capable to inhibit the production of TG, CHOL, G6PDH, lipid droplets. MPE 50 μg/mL and GM 75 μM were the most active to lower TG 57.95% and 59.72%, CHOL 33.33% and 31.68%, G6PDH 52.90%, 41.95%, lipid droplets 72.99% and 70.07% respectively. In conclusion mangosteen peel extract and γ-Mangostin are the most active antiobesity compared to α-Mangostin.Keywords
Glucose-6-Phosphate Dehydrogenase, Mangosteen, Obesity, Xanthones, 3T3-L1 Cells.Full Text
References
- Visscher T, Seidell J. The public health impact of obesity. Annu Rev Public Health. 2001; 22:355–75.
- WHO. The Asia-Pasific perspective: Redefining obesity and its treatment Australia. Health Communications Australia Pty; 2000.
- Deshpande M, Shengule S, Apte K, Wani M, Piprode V, Parab P. Anti-obesity activity of Ziziphus mauritiana: A potent pancreatic lipase inhibitor. Asian J Pharm Clin. 2013; 6(2):168–73.
- Yun J. Possible anti-obesity therapeutic from nature-a review. Phytochem. 2010; 71(14-15):1652–41.
- Gulati V, Harding I, Palombo E. Enzyme inhibitory and antioxidant activities of traditional medicinal plants: potential application in the management of hyperglycemia. BMC Complement Altern Med. 2012; 12:1–9.
- Rai P, Rai N, Rai A, Watal G. Role in LIBS elemental analysis of P. guajava responsible for glycemic potential. Inst Sci Tech. 2007; 35(2007):507–22.
- Sivangasari S, Vijayanand N, Rathinavel S. Antidiabetic activity of Cynodon dactylon (L.) Pers. extract in alloxan induced rats. Int J Pharm Pharm Sci. 2014; 6(4):1–5.
- Yeh G, Etsenberg D, Kaptchuk T, Philips S. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care. 2003; 26(4):1277–94.
- Haddad P, Azar G, Groom S, Boivin M. Natural health product, modulation of immune function and prevention of chronic diseases. J Evid Based Complementary Altern Med. 2005; 2(4):513–20.
- Pedraza-Chaverri J, Cardenas-Rodriguez N, OrozcoIbarra M, Perez-Rojas J. Medicinal properties of mangosteen (Garcinia mangostana). Food Chem Toxicol. 2008; 46(10):3227–39.
- Widowati W, Darsono L, Suherman J, Yelliantty Y, Maesaroh M. High Performance Liquid Chromatography (HPLC) analysis, antioxidant, antiaggregation of mangosteen peel extract (Garcinia mangostana L.). Int J Biosci Biochem Bioinfo. 2014; 4(2014):458–66.
- Jung HA, Su BN, Keller WJ, Mehta RG, Kinghom AD. Antioxidant xanthones from the pericarp of Garcinia mangostana (mangosteen). J Agric Food Chem. 2006; 54(6):2077–82.
- Pinto MM, Sousa ME, Nascimento MS. Xanthone derivatives: New insights in biological activities. Curr Med Chem. 2005; 12(21):2517–38.
- Widowati W, Darsono L, Suherman J, Fauziah N, Maesaroh M, Erawijantari PP. Anti-inflammatory Effect of mangosteen (Garcinia mangostana L.) peel extract and its compounds in LPS-induced RAW 264.7 Cells. Nat Prod Sci. 2016; 22(2016):147–53.
- Darsono L, Hidayat M, Maesaroh M, Fauziah N, Widowati W. Ex vivo study of Garcinia mangostana L. (mangosteen) peel extract and xanthones as anti-adipogenesis in HepG2 cell model. Int J Med Res Health Sci. 2015; 4(3):566–71.
- Obolskiy D, Pischel I, Siriwatanametanon N, Heinrich M. Garcina mangostana L.: A phytochemical and pharmacological review. Pyhtother Res. 2009; 23(8):1047– 65.
- Lobstein T, Leach R. Tackling obesities: Future choicesinternational comparisons of obesity trends, determinats and responses-evidence review, adults. London: UK Goverment Office for Science; 2007.
- Lobstein T, Baur L, Uauy R. Obesity in children and young people: A crisis in public health. Obesity Rev. 2014; 5(1):4–85.
- WHO. Reducing risks, promoting healthy life Geneva: World Health Organization; 2005.
- Sakagami Y, Ilnuma M, Piyasena K, Dharmaratne H. Antibacterial activity of alpha-Mangosteen against Vancomycin Resistant Enterococci (VRE) and synergism with antibiotics. Phytomed. 2005; 12(3):203–8.
- Franco M, Ordunez P, Caballero B. Impact of energy intake, physical activity, and population-wide weight loss on cardiovascular disease and diabetes mortality in Cuba, 1980-2005. Am J Epidemiol. 2007; 166(12):1374–80.
- Hidayat M, Soeng S, Prahastuti S, Erawijantari PP, Widowati W. Inhibitory potential of ethanol extract of Detam 1 soybean (Glycine max) seed and Jati belanda (Guazuma ulmifolia) leaves on adipogenesis and obesity models in 3T3-L1 cell line. Inhibitory potential of ethanol extract of Detam 1 soybean (Glycine max) seed and Jati belanda. J Sci Res Rep. 2015; 6(4):305–12.
- Hidayat M, Prahastuti S, Fauziah N, Maesaroh M, Balqis B, Widowati W. Modulation of adipogenesis-related gene expression by ethanol extracts of Detam 1 soybean and Jati belanda leaf in 3T3-L1 cells. Bangladesh J Pharmacol. 2016; 11(3):697–702. Crossref.
- Mutai E, Sunkara R, Vizcarra J, Walker LT, Verghese M. Antioxidant, enzyme inhibitory andanti-obesity potential of sorrel calyx extracts in 3T3-L1 adipocytes. Food and Nutrition Sciences. 2015; 6(5):452–65.
- Lee YJ, Choi DH, Cho GH, Kim JS, Kang DG, Lee HS. Arctium lappa ameliorates endothelial
- dysfunction in rats fed with fat/cholesterol diet. BMC Compl Alternative Med. 2012;
- Park MY, Sung MK. Carnosic acid inhibits lipid accumulation in 3T3-L1 adipocytes through attenuation of fatty acid desaturation. J Cancer Prev. 2015; 20(1):41–9.
- Rashid S, Genest J. Effect of obesity on high-density lipoprotein metabolism. Obesity (Silver String). 2007; 15(12):2957–88.
- Kim EJ, Lee HI, Chung KJ, Noh YH, Ro Y, Koo JH. The Ginsenoside-Rb2 lowers cholesterol and triacylglycerol levels in 3T3-L1 adipocytes cultured under high cholesterol or fatty acids conditions. BMB Reports. 2008; 42:194–9.
- Lei F, Zhang X, Wang W, Xing D, Xie W, Su H, et al. Evidence of anti-obesity effects of promegranate leaf extract in high-fat diet induced obese mice. Int J Obesity. 2007; 31(6):1023–9.
- Ahmadian M, Duncan RE, Jaworski K, SarkadiNagy E, Sul HS. Triacylglycerol metabolism in adipose tissue. Future Lipidol. 2007; 2(2):229–37.
- Stern JS, Peerson J, Mishra AT, Rao MV, Rajeswari KP. Efficacy and tolerability of a novel herbal formulation for weight management. Obesity. 2013; 21(5):921–7.
- Gutierrez-Orozco F, Chitchumroonchokchai C, Lesinski GB, Suksamrarn S, Failla ML. α-Mangostin: anti-inflammatory activity and metabolism by human cells. J Agric Food Chem. 2013; 61(16):3891–900.
- Tjahjani S, Widowati W, Khiong K, Suhendra A, Tjokropranoto R. Antioxidant properties of Garcinia mangostana L. (mangosteen) Rind. Procedia Chem. 2014; 13(2014):198–203.
- Ibrahim MY, Hashim NM, Mariod AA, Mohan S, Abdulla MA, Abdelwahab SI, et al. α-Mangostin from Garcinia mangostana Linn: An updated review of its pharmacological properties. Arabian J Chem. 2016 May; 9(3):317–29.
- Oppi-Williams C, Suagee JK, Corl BA. Regulation of lipid synthesis by liver X receptor α and sterol regulatory element-binding protein 1 in mammary epithelial cells. J dairy Sci. 2013; 96(1):112–21.
- Christy RJ, Kaetner KH, Geiman DE, Lane MD. CCAAT/ enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci USA. 1991; 15(6):2593–7.
- Tamori Y, Masugi J, Nishino N, Kasuga M. Role of peroxisome proliferator-activated receptor-gamma in maintenance of the characteristics of mature 3T3-L1 adipocytes. Diabetes. 2002; 51(7):2045–55.
- Feve B. Adipogenesis: cellular and molecular aspects. Best Pract Res Clin Endocrinol Metab. 2005; 19(4):483–99.
- Khattaka MM, Taher M, Ichawan SJ, Azaharia N. Selected herbal extracts improve diabetes associated factors in 3T3-L1 adipocyte. Procedia -Soc Behavioral Sci. 2013; 91:357–75.
- Silva MA, Vechetti-Junior IJ, do Nascimento AF, Furtado KS, Azevedo L, Ribeiro DA, et al. Effects of swim training on liver carcinogenesis in male Wistar rats fed a low-fat or high-fat diet. Appl Physiol Nutr Metab. 2012; 37(6):1101–9.
- Lagrost L, Gambert P. HDL and reverse cholesterol transport. Role of cholesterol ester transfer protein. C R Seances Soc Biol Fil. 1992; 186(4):405–13.
- Abuzaid AS, Iskandar EY, Kurniati NF, Adnyana IK. Preventive effect on obesity of mangosteen (Garcinia mangostana L.) pericarp ethanolic extract by reduction of fatty acid synthase level in monosodium glutamate and high-calorie diet-induced male wistar rats. Asian J Pharm Clin Res. 2016; 9.
- Adnyana IK, Abuzaid AS, Iskandar EY, Kurniati NF. Pancreatic lipase and α-Amylase inhibitory potential of mangosteen (Garcinia mangostana Linn.) pericarp extract. Int J Med Res Health Sci. 2016; 5:257–60.
- Taher M, Amiroudine MZ, Zakaria TM, Susanti D, Ichwan SJ, Kaderi MA, et al. α-Mangostin improves glucose uptake and inhibits adipocytes differentiation in 3T3-L1 cells via PPARγ, GLUT4, and leptin expressions. Evid-Based Complementary Altern Med. 2015; 2015:1–9.
- Shandiz HT, Razavi BM, Hosseinzadeh H. Review of Garcinia mangostana and its Xanthones in metabolic syndrome and related complications. Phytother Res. 2017; 31(8):1173–82.