Refine your search
Collections
Co-Authors
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Kumar, Vimal
- Anti-Diabetic Activity of a Polyherbal Formulation in Streptozotocin Induced Type 2 Diabetic Rats
Abstract Views :301 |
PDF Views:160
Authors
Affiliations
1 Institute of Pharmacy, Nirma University, Ahmedabad - 382481, Gujarat, IN
2 Atmiya Institute of Pharmacy, Rajkot - 360005, Gujarat, IN
3 K. Patel Phytoextractions Pvt Ltd, Mumbai - 400092, Maharashtra, IN
1 Institute of Pharmacy, Nirma University, Ahmedabad - 382481, Gujarat, IN
2 Atmiya Institute of Pharmacy, Rajkot - 360005, Gujarat, IN
3 K. Patel Phytoextractions Pvt Ltd, Mumbai - 400092, Maharashtra, IN
Source
Journal of Natural Remedies, Vol 16, No 4 (2016), Pagination: 148-152Abstract
The aim of the present study was to determine the anti-diabetic activity of a polyherbal formulation in streptozotocin induced type 2 diabetic rats. The hydroalcoholic extracts of Eugenia jambolana, Gymnema sylvestre, Momordica charantia and Andrographis paniculata and sodhana processed extract of Myristica fragrans were prepared. The 2 day old neonatal rats were injected with 90 mg/kg of streptozotocin intraperitoneally to induce type 2 diabetes. After six weeks of streptozotocin injection, polyherbal formulation was daily administered at a dose of 400 mg/kg body weight to diabetic rats for a period of 28 days. Blood samples were collected from the retro orbital plexus of the eye and blood glucose level was estimated by glucose oxidase-peroxidase method. The study indicated that polyherbal formulation at a dose of 400 mg/kg body weight showed significant decline (p<0.001) in blood glucose level.Keywords
OGTT, Polyherbal Formulation, Streptozotocin, Type 2 Diabetes.Full Text
References
- Manik S, Gautam V, Kalia AN. Anti-diabetic and antihyperlipedemic effect of allopolyherbal formulation in OGTT and STZ induced diabetic rat model. Indian J Exp Biol. 2013; 51:702–8.
- Kirana H, Srinivasan BP. Effect of Cycleapeltata Lam ischolar_mains aqueous extract on glucose levels, lipid profile, insulin, TNF α and skeletal muscle glycogen in type 2 diabetic rats.Indian J Exp Biol. 2010; 48:499–502.
- Vats RK, Kumar V, Kothari A, Mital A, Ramachandran U.Emerging targets for diabetes. Current Science. 2005; 88(2):241–9.
- Grover JK, Yadav S. Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol. 2002; 81:81– 100.
- Hayat MM, Wadhan P, Singh V. Hypoglycaemic activity of flower heads of Artemisia maritime in normal and alloxan-induced diabetic rats. J Nat Remedies. 2013; 13(1):9–14.
- Anonymous. The Ayurvedic Formulary of India Part-II, Ministry of Health and Family Welfare, Department of Indian Systems of Medicine and Homoeopathy. New Delhi. 2000.
- Shirwaikar A, Rajendran K, Punitha ISR. Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin – nicotinamide induced type 2 diabetic rats. J Ethnopharmacol. 2005; 97:369–74.
- Kirana H, Agrawal SS, Srinivasan BP. Aqueous extract of Ficusreligiosa Linn. reduces oxidative stress in experimentally induced type 2 diabetic rats. Indian J Exp Biol. 2007; 49:822–6.
- Patel PM, Patel NM, Goyal RK. Holistic classification of herbal anti-diabetics: a review. Pharma Times. 2006; 38(5):19–25.
- Lestari et al. Screening for PPAR γ agonist from Myristica fragrans Houtt. Seeds for the treatment of type 2 diabetes by in vitro and in vivo. Medical and Health Science Journal.2012; 12:7–15.
- Protective Effects of Fagonia cretica L. Extract in Cafeteria Diet Induced Obesity in Wistar Rats
Abstract Views :290 |
PDF Views:132
Authors
Divyang Patel
1,
Vimal Kumar
2
Affiliations
1 Institute of Pharmacy, Nirma University, Ahmedabad - 382481, Gujarat, IN
2 ITM School of Pharmacy, ITM Universe, Paldi, Vadodara - 391510, Gujarat, IN
1 Institute of Pharmacy, Nirma University, Ahmedabad - 382481, Gujarat, IN
2 ITM School of Pharmacy, ITM Universe, Paldi, Vadodara - 391510, Gujarat, IN
Source
Journal of Natural Remedies, Vol 20, No 3 (2020), Pagination: 185-190Abstract
Obesity is one of the major life style disorders which may lead to undesirable effects on cholesterol, triglycerides, blood pressure and insulin resistance and eventually increases the risk of various adverse conditions like ischemic heart disease, stroke, coronary artery disease & type 2 diabetes. The present investigation was undertaken to explore protective effects of aerial parts of Fagonia cretica L. extract in cafeteria diet induced obesity in Wistar rats. Female Wistar rats were provided with cafeteria diet (CD) for the period of 10 weeks to induce obesity. Fagonia cretica L. methanolic extracts (200 & 400 mg/kg) & standard drug orlistat (30 mg/kg) were administered for last 6 weeks along with the continuation of CD. Various primary metabolic indicators of obesity like daily food consumption, body weight, lipid profile, fecal fat content & fat pads were studied. Administration of methanolic extract of Fagonia cretica L. significantly stopped increase in daily food consumption & body weight gain as compared to obese control group. Improvement in lipid profile was also observed in the all treatment groups rats as compared to obese control group rats. Obtained results validate that supplementation of Fagonia cretica L. methanolic extracts in obese rats resulted in significant protection against various indicators of obesity.Keywords
Cafeteria Diet, Fagonia cretica L. Lipid Profile, Obesity.Full Text
References
- Verma R, Paraidathathu T. Herbal medicines used in the traditional Indian medicinal system as a therapeutic treatment option for overweight and obesity management: A review. International Journal of Pharmacy and Pharmaceutical Sciences. 2014; 6(2): 40-47.
- Abdollahi M, Imani B. A review on obesity and weight loss measures. Middle East Pharmacy. 2003; 11:6-10.
- Trivedi PC. Medicinal Plants Utilization & Conservation. Jaipur: Aavishkar Publication; 2009.
- Khare CP. Indian Herbal Remedies. New York: Springer; 2004. https://doi.org/10.1007/978-3-642-18659-2
- Ahmad SS. Medicinal wild plants from Lahore-Islamabad motorway (M-2). Pakistan Journal of Botany. 2007; 39:35575.
- Marwat SK, Khan MA, Ahmad M, Zafar M, Rehman FU. Ethnophytomedicines for treatment of various diseases in D.I.Khan district sarhad. Journal of agricultural research. 2008; 24:305-15.
- Sajid B, Alia E, Rizwana K, Uzma S, Alamgeer, Hafiz MI. Phytochemical screening and antimicrobial activity of Fagonia cretica plant extracts against selected microbes. Journal of Pharmacy Research. 2011; 4:962-63.
- Dastagir G, Hussain F, Khan AA. Antibacterial activity of some selected plants of family Zygophyllaceae and Euphorbiaceae. Journal of Medicinal Plant Research. 2012; 6: 5360-68. https://doi.org/10.5897/JMPR12.539
- Ali SS, Kasoju N, Luthra A, Singh A, Hallihosur S, Shahu A. Indian Medicinal plants as source of antioxidants, Food Research International. 2008; 41:1-15. https://doi.org/10.1016/j.foodres.2007.10.001
- Hussain A, Zia M, Mirza B. Cytotoxic and antitumor potential of Fagonia cretica L. Turkish Journal of Biology. 2007; 31:19-24.
- Sharma S, Joseph L, George M, Gupta V. Analgesic and antimicrobial activity of Fagonia indica. Pharmacology online. 2009; 3:623-632.
- Eldin HS., Gadir HA., Hassan AW. Evaluation of the hepatoprotective activity of Fagonia cretica L., Research & Review: Journal of Pharmacognosy & Phytochemistry 2015; 3:1-6.
- Anjum MI, Ahmed E, Jabbar A, Malik A, Ashraf M, Moazzam M. Antimicrobial constituents from Fagonia cretica. Journal of the Chemical Society of Pakistan. 2007; 6:634-39.
- Abhirami V, Khosa RL, Dhar SK, Sahai M. Investigation on Fagonia cretica-Its effect on hormonal profile and immunomodulation in rats. Ancient Science of Life. 1996; 15:4: 259- 63.
- Anonymous. Ayurvedic Pharmacopoeia of India. Part I. New Delhi; Ministry of Health and Family Welfare; 2001.
- Kamalakkannan S, Rajendran R, Venkatesh RV, Clayton P, Akbarsha MA. Anti-obesogenic and anti-atherosclerotic properties of Caralluma fimbriata extract. Journal of Nutrition & Metabolism. 2010; 285301. https://doi.org/10.1155/2010/285301 PMid:21234320 PMCid:PMC3018644
- Harris RB. The impact of high or low-fat cafeteria foods on nutrient intake and growth of rats consuming a diet containing 30% energy as fat. International Journal of Obesity and Related Metabolic Disorders. 1993; 17(6):307-15.
- Schwarz M, Lund EG, Setchell KD, Kayden HJ, Zerwekh JE, Björkhem I, Herz J, Russell DW. Disruption of Cholesterol 7α-Hydroxylase Gene in Mice II. Bile acid deficiency is overcome by induction of Oxysterol 7α- Hydroxylase. Journal of Biological Chemistry. 1996; 271(30): 18024-31. https://doi.org/10.1074/jbc.271.30.18024 PMid:8663430 PMCid:PMC4451191
- Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology. New Delhi: Elsevier; 2003.
- Gomez-Smith M, Karthikeyan S, Jeffers MS, Janik R, Thomason LA, Stefanovic B, Corbett D. A physiological characterization of the Cafeteria diet model of metabolic syndrome in the rat. Physiology & Behavior. 2016; 167:382-91. https://doi.org/10.1016/j.physbeh.2016.09.029 PMid:27705750
- Oliva L, Aranda T, Caviola G, Fernández-Bernal A, Alemany M, Fernández-López JA, Remesar X. In rats fed high-energy diets, taste, rather than fat content, is the key factor increasing food intake: a comparison of a cafeteria and a lipid- supplemented standard diet. Peer J. 2017; 5: e3697. https://doi.org/10.7717/peerj.3697 PMid:28929011 PMCid:PMC5600723