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Source
Journal of Natural Remedies, Vol 13, No 1 (2013), Pagination: 15-18
Abstract
In order to scientifically appraise some of the ethnobotanical uses of Diospyros melanoxylon (Roxb.), the present study was undertaken to examine analgesic properties in the stem bark and ischolar_main bark by ethanolic extracts in mice. The analgesic effect of ethanolic extracts was evaluated by 'hot plate' and 'acetic acid-induced writhing test' in mice by using pentazocine (5 mg/kg) and asprin (50 mg/kg) simultaneously as reference drugs. Diospyros melanoxylon (Roxb.) stem bark's ethanolic extracts possess analgesic activity, but here we also used ischolar_main bark to check the extent of difference in activity. The ethanolic extract of stem bark (200 mg/kg) possessed significant analgesic activity, as in acetic acid-induced writhing test, the writhing count was reduced significantly compared to standard and ischolar_main bark ethanolic extracts. In the hot plate method with ethanolic extracts of stem bark (200 mg/kg), the basal reaction time was increased significantly (p<0.01) and the percentage increase in threshold to pain was also significant as compared to standard.
Keywords
Diospyros melanoxylon, Analgesic Activity, Acetic acid-induced writhing test, Hot plate method
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