Journal of Natural Remedies

Z. A. Bhat , S. H. Ansari , H. M. Mukhtar , T. Naved , N. A. Khan , I. A. Chashoo

Abstract

Objective: To evaluate the anti-hyperglycemic activity of alcoholic extract of Aralia cachemirica Decne ischolar_mains. Materials and methods: The alcoholic extract of Aralia cachemirica was tested for anti-hyperglycemic activity on normal fasted, glucose loaded and alloxan induced diabetic rats. Blood glucose levels were evaluated at 0,1 and 3 h in normal fasted rats at 0, 30 and 90 min in glucose loaded rats; at 0, 1 and 3 h in acute and at days 1, 3, 7 and 10 in sub-acute studies of alloxan induced diabetic rats after extract administration of 250 mg/kg. Results: In both acute and sub acute-studies the ethanolic extract showed statistically significant anti-hyperglycemic and an enhanced glucose tolerance activity while it had no effect on normal fasted rats. Conclusion: Aralia cachemirica posses statistically significant antihyperglycemic activity in both acute and sub-acute studies of alloxan induced diabetes and also has an enhanced glucose tolerance activity.

Keywords

Aralia cachemirica Decne, Roots, Anti-hyperglycemic, Glucose Tolerance

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H. M. Mukhtar , S. H. Ansari , M. Ali , T. Naved , Z. A. Bhat

Abstract

Objective: To evaluate the anti-hyperglycemic activity of water extract of Psidium guajava stem bark. Materials and methods: The water extract of stem bark of Psidium guajava was tested for its hypoglycemic activity in normal glucose loaded and alloxan-induced hyperglycemic Wistar rats. Blood glucose levels were evaluated at intervals of 30 and 90 minutes in normal glucose loaded animals, at intervals of 0, 1 and 3 h in acute study and at days 1, 3, 7 and 10 during sub acute treatment after extract administration at an oral dose of 250 mg/kg. Results: During both acute and sub-acute tests, the water extract showed statistically significant and considerable anti-hyperglycemic activity and enhanced glucose tolerance in normal glucose loaded rats. Conclusion: Psidium guajava stem bark possessed statistically significant anti-hyperglycemic potential in alloxan induced diabetic rats and enhanced glucose tolerance in glucose loaded normal rats.

Keywords

Psidium guajava Linn., Hypoglycemic, Hyperglycemic

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H. M. Mukhtar , S. H. Ansari , T. Naved , Z. A. Bhat

Abstract

Objective: To evaluate the hypoglycemic activity of ethanol extract of Psidium guajavaleaves. Materials and methods: The ethanol extract of leaves of Psidium guajava was tested for its hypoglycemic activity in alloxan-induced hyperglycemic Wistar rats. Results: In both acute and sub-acute tests, the ethanol extract, at an oral dose of 250 mg/kg, showed statistically significant and considerable hypoglycemic activity. Conclusion: Psidium guajava leaves possess statistically significant hypoglycemic activity.

Keywords

Psidium guajava Linn., Hypoglycemic Activity

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