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The present investigation was carried out to evaluate the lipid peroxidation and antioxidant nature of aqueous extract of Adhatoda vasica (AEAV) on D-galactosamine (D-GalN) induced hepatic damage in wistar albino rats. Hepatic damage was induced by intraperitonial injection of DGalN (500 mg/kg, bw) for 2 days. AEAV extract (350 mg/kg, bw) was given orally for 21 days before the induction of hepatic damage. The levels of lipid peroxides (LPO) under basal and also in the presence of inducers (H₂O₂, ascorbate and FeSO4) were estimated in liver of control and experimental animals. enzymic such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non-enzymic antioxidants like glutathione (GSH), vitamin C (vit C) and vitamin E (vit E) and total thiols (TSH) levels were determined in all the groups of animals. A significant increase in LPO levels were observed while the levels of enzymic and non-enzymic antioxidant were decreased, in D-GalN induced rats. These altered enzyme levels were ameliorated significantly in AEAV pretreated animals. This protective effect of AEAV was associated with inhibition of LPO induced by D-GalN and to maintain the antioxidant enzyme levels. From this study it is concluded that the pre-treatment of AEAV has an antioxidant activity against D-GalN induced hepatic damage.

Keywords

D-galactosamine, Adhatoda Vasica, Lipid Peroxidation, Antioxidants Enzymes, Liver Damage

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