Journal of Natural Remedies

Shizuo Toda , Yoshiaki Shirataki

Abstract

Objective: To investigate the inhibitory effect of prenylflavonoid, 5,7,4'-trihydroxy-6,8- diprenylisoflavone isolated from Euchresta japonica, on oxidative stress. Materials and methods: The inhibitory effect of 5,7,4'-trihydroxy-6,8-diprenylisoflavone was tested on copper-induced protein oxidative modification in vitro. Result: 5,7,4'-trihydroxy-6,8-diprenylisoflavone inhibited copperinduced protein oxidative modification. Its inhibitory effect was stronger than that of genistein as a non-prenylated isoflavone. Conclusion: The results demonstrated that prenylflavonoid, 5,7,4'-trihydroxy- 6,8-diprenylisoflavone isolated from Euchresta japonica, has inhibitory effect on oxidative stress as copper-induced protein oxidative modification in vitro.

Keywords

5,7,4'-trihydroxy-6,8-diprenylisoflavone, Euchresta japonica, Copper, Protein Oxidative Modification

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