Refine your search
Collections
Co-Authors
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Umukoro, S.
- Effects of the Methanol Leaf Extract of Sansevieria liberica on the Central Nervous System in Mice
Abstract Views :467 |
PDF Views:542
Authors
Source
Journal of Natural Remedies, Vol 8, No 2 (2008), Pagination: 242-246Abstract
Objective: To investigate the effects of the methanol leaf extract of Sansevieria liberica (SL) on the Central Nervous System (CNS) in mice. Materials and methods: The spectrum of activities studied, includes the effects of SL on hexobarbital-induced sleeping time, on picrotoxin-induced convulsions and on pains produced by acetic acid and by noxious heat. Results: The extract was found to exhibits sedative effect, as it prolongs hexobarbital-induced sleeping time in mice. SL was also found to possess analgesic property, as it reduced the pain episodes produced by acetic acid and by noxious heat in mice. However, the extract did not demonstrate anticonvulsant property, as it failed to prevent convulsions and could not delay significantly the onset of seizures in picrotoxin-treated animals. Conclusion: The results of the study suggest that the leaf extract of Sanseviera liberica contained phytochemically active ingredients with CNS depressant and analgesic effects.Keywords
Sansevieria liberica, Sedative, Anticonvulsant, AnalgesicFull Text
- Pharmacological Evaluation of the Central Nervous System Activity of Aframomum melegueta Seed Extract in Mice
Abstract Views :614 |
PDF Views:715
Authors
Source
Journal of Natural Remedies, Vol 5, No 2 (2005), Pagination: 141-146Abstract
Objective: To study the effects of intraperitoneal injection of aqueous seed extract of Aframomum melegueta (AM) on the central nervous system (CNS) in mice. Materials and methods: The study sought to evaluate the effects of the extract on the general behaviour of the animals (Irwin test), on pentobarbitone-induced sleeping time, on methamphetamine-induced stereotyped behaviour, on motor coordination, and on convulsive seizures induced by isoniazid and picrotoxin. AM was tested at a dose range of 5-400 mg/kg. Results: AM (50-200 mg/kg) produced a significant decrease in spontaneous motor activity and also caused a dose-related prolongation of pentobarbital-induced sleeping time. At a dose range of 100-400 mg/kg, a significant inhibition of methamphetamine (35 mg/kg, i. p) induced stereotyped behaviour was observed. Furthermore, it offered a significant protection against convulsions induced by isoniazid (200 mg/kg, i.p). However, it failed to modify the convulsive action of picrotoxin (10 mg/kg, i.p) and did not cause any significant effect in the motor coordination of animals on the rota-rod machine. Conclusion: The results of this study suggest that A. melegueta seed extract possesses central nervous system depressant activity.Keywords
Aframomum melegueta, Sedative, Anti-stereotypic, Anticonvulsant, Pentobarbital, Methamphetamine, IsoniazidFull Text