Journal of Natural Remedies

S. Umadevi , G. P. Mohanta , V. Chelladurai , P. K. Manna , R. Manavalan

Abstract

Objective: To investigate the antibacterial and antifungal activity of chloroform, acetone, methanol and aqueous extracts of whole plant Andrographis echiodes. Materials and methods: Antimicrobial activity was studied at different concentrations of the extract dissolved in dimethyl sulfoxide against seven strains of bacteria, three strains of fungi and one yeast by disc diffusion method. The minimum inhibitory concentration of the extracts were also determined. Results: All the extracts except aqueous posses antimicrobial activity against most of the organisms tested. The minimum inhibitory concentrations ranges from 0.05 mg/ml to 5 mg/ml on tested bacteria. Conclusion: The activities of Andrographis echiodes confirms with its folk use as remedy for fever. In addition to this use it may also be used topically for treatment of bacterial and fungal infections.

Keywords

Andrographis echiodes, Antibacterial and Antifungal Activity, Bacteria. Fungi, Yeast

Full Text

   

S. Umadevi , G. P. Mohanta , R. Kalaiselvan , P. K. Manna , R. Manavalan , S. Sethupathi , K. Shantha

Abstract

Objective: To evaluate the hepatoprotective effect of leaf extract of Flaveria trinervia in rat. Materials and methods: The methanolic extract of the plant was evaluated for the hepatoprotective activity against carbon tetrachloride (CCl₄)-induced liver damage in rats by administering orally at 400 mg/kg dose for 10 days. Such effect was compared with silymarin as a standard hepatoprotective drug. In the serum, glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, alkaline phosphatase, total protein, albumin, triglyceride and cholesterol contents were determined. In the liver, total protein, peroxide, phospholipid and glutathione levels were estimated. Results: The extract significantly reversed the elevated enzyme levels and altered biochemical parameters compared to control and silymarin. Besides, a significant reduction of the CCl₄-induced changes in the liver histopathology was also observed. Conclusion: The extract showed a considerable potential for hepatoprotective activity possibly by the antioxidant property. Keywords: Flaveria trinerv

Keywords

Flaveria trinervia, Hepatoprotective, Silymarin, Carbon Tetrachloride

Full Text