Journal of Natural Remedies

A. M. Baheti , B. S. Rathi , K. R. Khandelwal , S. L. Bodhankar

Abstract

Objective: Husk of Cocos nucifera was screened for diuretic properties. Method: The diuretic properties of aqueous and alcoholic extract of Cocos nucifera husk were evaluated by determination of urine volume, electrolyte concentration and diuretic potency in male albino rats. Different concentrations of aqueous and alcoholic extract (250 mg/kg, 500mg/kg) were orally administered to hydrated rats and their urine output was immediately measured after 5 h of treatment. Frusemide (10mg/kg) was used as reference drug while normal saline (0.9%) solution was used as control. Result: Both the extract exhibited dose dependent diuretic property. The onset of diuretic action was extremely prompt (within 1 h) and lasted throughout the studied period (upto 5 h). Both extract caused marked increase in Na⁺, K⁺ and Cl^-level. Conclusion: The result of this experiment suggests that Cocos nucifera husk extract possessed significant diuretic activity.

Keywords

Cocos nucifera, Aqueous Extract, Alcohol Extract, Diuretic Activity

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C. D. Kamat , K. R. Khandelwal , S. L. Bodhankar , S. D. Ambawade , N. A. Mhetre

Abstract

Objective: The objective of the present investigation was to study hepatoprotective activity of aqueous extract of leaves of Feronia elephantum Correa., Fam. Rutaceae using carbon tetrachloride-induced liver damage model in rats. Methods: Liver damage in rats was produced by carbon tetrachloride (1.25 mg/kg, i.p.) in olive oil. Aqueous extract of leaves of the plant was administered to rats daily for seven or fifteen days. The physical, functional and biochemical parameters were investigated. Histopathological changes in liver were studied. Concurrently Liv 52^® was used as standard hepatoprotective agent. Results: The result indicated that physical, functional and biochemical changes produced by carbon tetrachloride were restored to normal by aqueous extract of the leaves of Feronia elephantum Liv 52^®. The hepatoprotective action of aqueous extract of leaves and Liv 52^® was confirmed by histopathological examination. Conclusion: The aqueous extract of leaves of Feronia elephantum showed hepatoprotective effect in carbon tetrachloride induced liver damage model in rats.

Keywords

Hepatoprotective, Feronia elephantum Correa

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