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Chandran, R. V. Pradeep
- Toxicity Studies on Amukkarac Curanam - a Siddha Poly Herbal Drug
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PDF Views:486
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Journal of Natural Remedies, Vol 8, No 2 (2008), Pagination: 232-241Abstract
Objective: The effect of Amukkarac curanam (AC), a widely used Siddha medicine was evaluated for acute and chronic toxicity in rats. Material and methods: Amukkarac is botanically equated to Withania somnifera Dunal. Acute dosages were 0.5, 1.0, 1.5, 2.0, 2.5, 3.0 and 5.0 g/kg body weight while the chronic dosage was 500 mg/kg body weight /day. All external morphological, hematological, serum parameters, histopathological, in addition to body weight and vital organ weights were recorded. Results and conclusion: During this investigation no significant mortality was observed. The results showed that AC at the given dose of 500 mg/kg body weight did not produce any significant toxic effect in rats during 90 days period of the treatment.Keywords
Chronic Toxicity, Hematology, Marker Enzymes, Lipid ProfileFull Text
- Hepatoprotective Effect of Amukkarac curanam in Acetaminophen Intoxicated Rats
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PDF Views:377
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Journal of Natural Remedies, Vol 9, No 1 (2009), Pagination: 111-115Abstract
Objective: The hepatoprotective action of Amukkarac curanam (AC), a widely used Siddha medicine was evaluated using acetaminophen-induced hepatic damage in rats. Material and methods: AC was administered orally at a dose of 500 mg/kg body weight for 7 days. Serum levels of transaminase (AST, ALT), alkaline phosphate (ALP), bilirubin, Total protein (TP) and albumin (Alb) were used as the biochemical markers of hepatotoxicity. Liver thiobarbituric acid reactive substances and histopathological studies were also done to confirm the biochemical changes. Results and Discussion: The results of the study indicate that pretreatment with AC significantly reversed the increased levels of serum marker enzymes such as AST, ALT, ALP and bilirubin, when compared to acetaminophen-induced group. The level of liver thiobarbituric acid reactive substances was also brought to near normal. AC has protected the liver from acetaminophen-induced damage. Probable mechanism of action is by protection against oxidative damage produced by acetaminophen.Keywords
Acetaminophen, Amukkarac Curanam, Marker Enzymes, Thiobarbituric Acid Reactive Substances, Histopathological StudiesFull Text