Journal of Natural Remedies

Ajay Kshirsagar , P. A. Patil , Purnima Ashok , Basavaraj Hulkoti

Abstract

Objective: To evaluate the chloroform extract of Calotropis gigantea flowers (CCGF) and ethanol extract of Calotropis gigantea flowers (ECGF) for their possible anti-inflammatory (AI) and anti-ulcer (AU) activities. Method: The anti-inflammatory effect of CCGF and ECGF (200mg/kg; p.o.) was investigated in carrageenan induced rat paw edema and cotton pellet induced granuloma model. The AU activity studied in pylorus ligation and aspirin induced gastric ulcers model. The aspirin and ranitidine were used as standards for AI and AU studies respectively. Results: The CCGF and ECGF significantly reduced rat paw edema (p > 0.05 to > 0.01) and dry weight granuloma (p > 0.01). Similarly, both extracts treated group were significantly (p > 0.01) protected from pyloric ligation and aspirin induced gastric ulcers. These effects were statistically significant. Conclusion: The results suggest that the CCGF and ECGF possess significant AI and AU activities. The observed effect may be due to the presence of protease like bioactive constituent.

Keywords

Calotropis gigantea Flower, Anti-inflammatory, Anti-ulcer, Aspirin

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Purnima Ashok , S. Arulmozhi , B. P. Bhaskara , R. Rajendran , B. G. Desai

Abstract

Objective: The purpose of the present study was to evaluate food intake inhibitory activity of aqueous extract of Sida cordifolia (AESC) and alcoholic extract of Withania somnifera (AEWS). Both Sida cordifolia Linn. (Malvaceae) and Withania somnifera Linn. (Solanaceae) are widely growing medicinal plants and have been reported to possess number of medicinal properties. Materials and methods: The food intake inhibitory activity of different concentrations of AESC and AEWS (0.5% w/w, 1% w/w and 1.5% w/w) were evaluated by supplementing them with normal feed of rats for seven days, measuring their body weight and food intake daily and compared with the control. Results: There was a significant decrease in food intake (P<0.001) and body weight (P<0.01) with 1 % w/w and 1.5 % w/w of AESC while decrease in food intake and body weight with 0.5 % w/w of AESC was not significant. AEWS showed a significant (P<0.05) decrease in food intake only, but no significant decrease in body weight was observed with AEWS at any dose level. Conclusion: Both extracts were found to have significant food intake inhibitory activity. However when compared to AEWS, AESC was found to be more effective in reducing the food intake and bodyweight.

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