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Objective: To study the nootropic activity of leaves of Moringa oleifera. Methods: Toluene-ethylacetate fraction of methanolic extract of Moringa oleifera (MOE) leaves was assessed for its nootropic activity using passive shock avoidance paradigm and elevated plus maze. MOE ( 50 and 100 mg/kg ) was compared with Piracetam (100 mg/kg ). Scopolamine (1 mg/kg) was used to induce cognitive dysfunction. The extract was also studied for its effect on gross behaviour. Results: MOE (50 and 100 mg/kg ) significantly decreased Transfer Latency(TL) on Day 2. The extract reduced the latency to reach the SFZ and the number of mistakes. No adverse effects were observed upto a dose of 200 mg/kg. Conclusion: Thus the leaves of Moringa oleifera possess a potential for exploring the nootropic principle.

Keywords

Nootropic, Moringa oleifera, Passive Avoidance, Plus Maze

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