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Afni, Merry
- Anti-Inflammatory Potential of Gandarusa (Gendarussa vulgaris Nees) and Soursoup (Annona muricata L) Extracts in LPS Stimulated-Macrophage Cell (RAW264.7)
Abstract Views :376 |
PDF Views:186
Authors
Dian Ratih Laksmitawati
1,
Ajeng Prima Prasanti
1,
Nadia Larasinta
1,
Gloria Agitha Syauta
1,
Rivanny Hilda
1,
Hesty Utami Ramadaniati
1,
Anisa Widyastuti
1,
Nadia Karami
1,
Merry Afni
2,
Dwi Davidson Rihibiha
2,
Hanna Sari W. Kusuma
2,
Wahyu Widowati
3
Affiliations
1 University of Pancasila, Jakarta, ID
2 Biomoleculer and Biomedical Research Center, Aretha Medika Utama, Bandung, ID
3 Medical Research Center, Maranatha Christian University, Bandung, ID
1 University of Pancasila, Jakarta, ID
2 Biomoleculer and Biomedical Research Center, Aretha Medika Utama, Bandung, ID
3 Medical Research Center, Maranatha Christian University, Bandung, ID
Source
Journal of Natural Remedies, Vol 16, No 2 (2016), Pagination: 73-81Abstract
Inflammation is one of the important biological responses to injury. Anti-inflammatory is therefore proposed to treat both acute and chronic inflammation. Chemical compounds of various plants are widely used in treatment of inflammation. Objective: This study aims to evaluate anti-inflammatory potential of G. vulgaris extract (GVE) and A. muricata extract (AME) on LPS-stimulated murine macrophage cell line (RAW264.7). Cell viability assay to evaluate nontoxic concentration in cell line was performed with MTS assay. Parameters to determine anti-inflammatory activity between treatment group and non treated cells, were IL-1β, TNF-α, and IL-6 which was measured with Elisa, and NO level which was measured with nitrate/nitrite colorimetric assay. Both GVE and AME of 50 and 10 μg/mL showed high viability (>90%) and it was not significantly different compared to control, makes it suitable for treatment. GVE and AME of 50 μg/mL resulted low TNF-α level in RAW264.7(313.16pg/mL and 264.69 pg/mL respectively), as well as IL-1β level (903.53 pg/mL and 905.00 pg/mL respectively) and IL-6 (175.88 pg/mL and 219.13 pg/mL respectively). Whereas, GVE and AME of 75 μg/mL showed lower NO level (9.76 μM and 9.79 μM respectively) compared to untreated cells. This research revealed that GVE and AME possess the anti-inflammatory potential indicated by inhibition of inflammatory mediators including TNF-α, IL-1β, IL-6 and NO.Keywords
Annona muricata L, Anti-Inflammtory, Gendarussa vulgaris Nees, RAW264.7 Cell Line.Full Text
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- Antioxidant and Anti Aging Assays of Oryza sativa Extracts, Vanillin and Coumaric Acid
Abstract Views :506 |
PDF Views:300
Authors
Wahyu Widowati
1,
Nurul Fauziah
1,
Heddy Herdiman
1,
Merry Afni
2,
Ervi Afifah
2,
Hanna Sari W. Kusuma
2,
Hayatun Nufus
2,
Seila Arumwardana
2,
Dwi Davidson Rihibiha
2
Affiliations
1 Medical Research Center, Maranatha Christian University, Jl Prof Drg Surya Sumantri No 65 Bandung 40164, West Java, ID
2 Aretha Medika Utama, Biomolecular and Biomedical Research Center, Jl Babakan Jeruk 2, No 9, Bandung 40163, West Java, ID
1 Medical Research Center, Maranatha Christian University, Jl Prof Drg Surya Sumantri No 65 Bandung 40164, West Java, ID
2 Aretha Medika Utama, Biomolecular and Biomedical Research Center, Jl Babakan Jeruk 2, No 9, Bandung 40163, West Java, ID
Source
Journal of Natural Remedies, Vol 16, No 3 (2016), Pagination: 88-99Abstract
Aging is a natural process in humans as accumulation of oxygen-derived free radicals which leads to the activation of hyaluronidase, collagenase and elastase, that can further contribute to cellular and tissue damage. Bioactive compounds from plants have been used as antioxidant that might inhibit aging processes as well. This study aimed to determine antioxidant and anti aging properties of Oryza sativa Extract (OSE), and its compounds, vanillin and coumaric acid. The phytochemical analysis of OSE was performed with Farnsworth modified method. Antioxidant activities were performed by measurement of 2,2-diphenyl 1-pichylhydazyl (DPPH) free radical scavenger, Ferric Reducing Antioxidant Power (FRAP), and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) reducing activity, while anti aging assay were observed through inhibitory of elastase, collagenase, and hyaluronidase activities. Phytochemical analysis showed the presence of terpenoids and saponins in high level. OSE showed lowest DPPH activity (IC50 = 314.51 μg/mL) compared to vanillin (IC50 = 283 μg/mL) and coumaric acid (IC50 = 255.69 μg/mL). In ABTS assay, OSE resulted lowest activity(IC50 = 145.67 μg/mL), compared to vanillin (IC50 = 4.96 μg/mL) and coumaric acid (IC50 = 1.67 μg/mL). OSE also showed the lowest FRAP-reducing activity (21.26 μM Fe(II)/μg), compared to vanillin (35.05 μM Fe(II)/μg) and coumaric acid (48.52μM Fe(II)/μg). OSE showed the lowest collagenase, elastase, and hyaluronidase inhibitory activity (IC50 = 816.78,107.51, and 203.13 μg/mL), compared to vanillin (IC50 = 16.27, 14.46, 45.23 μg/mL respectively) and coumaric acid (IC50 = 146.89, 25.38, 8.21 μg/mL respectively). In summary, OSE possess the lowest antioxidant and anti aging activities compared to vanillin and coumaric acid.Keywords
Antioxidant, Anti Aging, Coumaric Acid, Oryza sativa, Vanillin.Full Text
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