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Iyer, M.
- Anxiolytic Activity of Trigonella foenum-greacum Seeds
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Journal of Natural Remedies, Vol 4, No 1 (2004), Pagination: 61-65Abstract
Objective : To study the anxiolytic activity of Trigonella foenum-graecum (Fenugreek) seeds. Methods: Methanol extract (ME) and ethyl acetate fraction of methanol extract (EAF) were assessed for their anxiolytic activity. The ME (30,100 mg/kg) and EAF (30, 100mg/kg) administered intra-peritoneally exhibited anxiolytic activity in elevated plus maze (EPM) paradigm, Light/Dark apparatus (LDA) and Open field apparatus (OFA). Meta-chlorophenylpiperazine (m-CPP, 1 mg/kg), a 5-HT2 receptor agonist, known to induce anxiety was used to study antagonism with different doses of EAF and with diazepam. Results : In EPM, both ME and EAF increased the time spent in open arms and the number of entries in open arms. In Light: Dark apparatus, ME and EAF increased the time spent in lit zone. In OFA, the number of assisted rearing and the number of squares traversed were increased. Different doses of EAF (30,60,120,240,480 mg/kg ) also antagonized the effects of m-CPP( 1 mg/kg). The ED50 value of EAF was found to be 48.97mg/kg. Conclusion : Thus, the seeds of Trigonella foenum graecum contain bioactive principle(s) which possess anxiolytic activity.Keywords
Anxiolytic, Trigonella foenum-graecum, 1,3-ChlorophenylpiperazineFull Text
- Anti-nociceptive Activity of Mundulea sericea Leaves
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Journal of Natural Remedies, Vol 4, No 2 (2004), Pagination: 127-130Abstract
Objective: To study the analgesic activity of leaves of Mundulea sericea. Methods: Methanolic extract (30 mg/kg and 70 mg/kg) of Mundulea sericea (Leguminosae, subfamily Papilionaceae) was investigated for analgesic activity using acetic acid-induced writhing and tail immersion method. The extract was studied for its effect on pentobarbitone-induced sleep and on gross behavior. Results: Methanolic extract (30 mg/kg and 70 mg/kg) significantly increased latency to flick tail in tail immersion test and reduced the number of writhings induced by acetic acid. The extract increased the duration of pentobarbitone-induced sleep. No adverse effects were observed upto a dose of 200 mg/kg of the extract. Conclusion: Leaves of Mundulea sericea possess central as well as peripheral analgesic activity.Keywords
Mundulea sericea, Analgesic, Tail Immersion, WrithingFull Text