Journal of Natural Remedies

Perwez Alam , M. Ali

Abstract

Phytochemical investigation of the ischolar_main bark of Ricinus communis Linn (Euphorbiaceae) furnished three new aliphatic alcohols and their structures have been elucidated as 24- phenyl tetracosan- 6-one-19-ol-, n-tricos-10en- 1-ol-3-one and 24-phenyl-n-tetracosan-10-one -19β-ol on the basis of spectral data analysis and chemical reaction.

Keywords

Ricinus communis, Euphorbiaceae, Aliphatic Alcohols, Maldi Tof MS

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H. M. Mukhtar , S. H. Ansari , M. Ali , T. Naved , Z. A. Bhat

Abstract

Objective: To evaluate the anti-hyperglycemic activity of water extract of Psidium guajava stem bark. Materials and methods: The water extract of stem bark of Psidium guajava was tested for its hypoglycemic activity in normal glucose loaded and alloxan-induced hyperglycemic Wistar rats. Blood glucose levels were evaluated at intervals of 30 and 90 minutes in normal glucose loaded animals, at intervals of 0, 1 and 3 h in acute study and at days 1, 3, 7 and 10 during sub acute treatment after extract administration at an oral dose of 250 mg/kg. Results: During both acute and sub-acute tests, the water extract showed statistically significant and considerable anti-hyperglycemic activity and enhanced glucose tolerance in normal glucose loaded rats. Conclusion: Psidium guajava stem bark possessed statistically significant anti-hyperglycemic potential in alloxan induced diabetic rats and enhanced glucose tolerance in glucose loaded normal rats.

Keywords

Psidium guajava Linn., Hypoglycemic, Hyperglycemic

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