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Ganachari, M. S.
- Effect of Ziziphus jujuba Leaves Extract on Phagocytosis by Human Neutrophils
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Journal of Natural Remedies, Vol 4, No 1 (2004), Pagination: 47-51Abstract
Objective: To study the effect of hydroalcoholic extract of Ziziphus jujuba leaves on neutrophil phagocytic function. Methods: The different concentrations (5, 10, 25, 50 and100μg/ml) of Ziziphus jujuba leaves extract was subjected, to study its effect on different in vitro methods of phagocytosis such as neutrophil locomotion and chemotaxis test, in vitro immunostimulant activity by slide method and qualitative nitro blue tetrazolium test using human neutrophils. Results: The Ziziphus jujuba leaves extract has stimulated chemotactic, phagocytic and intracellular killing potency of human neutrophils at the concentration range of 5-50μg/ml. Conclusion: The hydroalcoholic extract of Ziziphus jujuba leaves stimulates cell-mediated immune system by increasing neutrophil phagocytic function.Keywords
Immunostimulant Activity, Neutrophils, Phagocytosis, Ziziphus jujuba- Anti-ulcer Properties of Ziziphus jujuba Lam Leaves Extract in Rats
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Journal of Natural Remedies, Vol 4, No 2 (2004), Pagination: 103-108Abstract
Objective: To evaluate the antiulcer activity of Ziziphus jujuba leaves extract (ZJE) at various doses using different experimentally induced gastric ulcer models in rats. Methods: Gastric ulcers were induced in rats by Pylorus ligation, 80% ethanol (1ml/rat) and aspirin (200mg/kg). In pylorus ligation induced ulcer model the parameters studied were gastric volume, free acidity, total acidity and ulcer index. Lesion index and gastric mucus content were determined in ethanol induced ulcer model and in aspirin induced ulcer model the ulcer index was determined. Results: In pylorus ligation model, ZJE pretreatment caused significant reduction in gastric volume, free acidity, total acidity and ulcer index as compared to control group. In ethanol-induced ulcers, ZJE was effective in reducing lesion index and increasing the gastric mucus content. It was also effective in decreasing ulcer index in aspirin-induced ulcers. All the results obtained with ZJE were dose dependent. Conclusions: The results suggest that ZJE possesses significant and dose dependent antiulcer activity. The antiulcer activity of ZJE can be attributed to its cytoprotective and antisecretory action.Keywords
Ziziphus jujuba, Antisecretory, Cytoprotective, Gastric Ulcer- Anti-inflammatory Activity of Ziziphus jujuba Lam Leaves Extract in Rats
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Journal of Natural Remedies, Vol 4, No 2 (2004), Pagination: 183-185Abstract
Objective: To evaluate the anti-inflammatory activity of the alcoholic extract of Ziziphus jujuba Lam leaves in albino rats. Materials and methods: Ziziphus jujuba leaves were extracted with 90 % ethanol and the extract was screened for anti-inflammatory activity at the doses of 200, 400 and 600 mg/kg using acute carrageenan induced paw oedema in albino rats. Diclofenac sodium (100 mg/kg, p.o.) was used as standard reference drug. Results: The % inhibition of paw edema at 3 h after carrageenan administration produced by Ziziphus jujuba leaves extract at the dose of 200, 400 and 600 mg/kg was 44.5%, 62.2% and 81.8% respectively when compared to control. The paw oedema attenuating effect of Ziziphus jujuba leaves extract at the dose of 600 mg/kg was comparable with that produced by diclofenac sodium (88.6%). Conclusion: The present study indicates that Ziziphus jujuba leaves extract possess significant anti-inflammatory activity against carrageenan-induced rat paw edema.Keywords
Anti-inflammatory, Carrageenan, Inflammation, Ziziphus jujuba- Anti-obese Activity of Ziziphus jujuba Lam Leaves Extract in Dietary Obese Rats
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