Journal of Natural Remedies

K. L. Bairy , K. Roopa , S. Malini , C. M. Rao

Abstract

Objectives: To study the possible antiulcer effects of alcoholic extract of Tinospora cordifolia in different animal models of ulcers. Methods and materials : The alcoholic extract of the whole plant was prepared and tested for antiulcer activity at the dose of 400 mg/Kg PO in pyloric ligation, ibuprofen and cold restraint induced gastric ulcer models. The effect of the extract was compared with famotidine (3.6mg Kg PO). Besides, the effect was also compared with misoprostal (7.2 μg/kg PO) in case of ibuprofen induced ulcer model. The antiulcer effects of the drugs were assessed on the parameters such as number, size and index of ulcers and the volume, acidity, and pH of gastric juice. Result: The extract of Tinospora cordifolia, famotidine and misoprostol significantly (p<0.05) reduced ulcer index in the models employed. While the antiulcer effect of the extract was comparable to that of the standard drugs in ibuprofen and stress induced ulcer models, its effect was significantly (p<0.05) lesser than that of famotidine in pyloric ligation method. Conclusion: Tinospora cordifolia possesses gastric ulcer protective principles.

Keywords

Tinospora cordifolia, Gastric Ulcer, Famotidine, Antiulcer

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K. L. Bairy

Abstract

Wounds are perhaps, inescapable events in the life of an organism and at times they are dangerous or even life threatening. In the management of wound, control of pain, bleeding and infection have received due attention and have been successfully dealt with. These achievements, together with astounding advances in the surgical skill, and techniques, have greatly improved the asthetics of wound scar. Yet there is a ring of truth in what has been recently emphasized "the scope of surgery over the centuries has been directly proportional to the degree to which we have been able to depend upon repair and resistance to infection. Extensive screening of plants for wound healing profile has shown some good results. These plant products affect various phases (coagulation,inflammation, fibroplasia, collagenation, epithelization and wound contraction) of healing alike or differently. This is possible because various phases of wound healing are apparently independent, but interlinked and run concurrently. Some plant products are already in use. Isolation of active principles of these plants may provide the basic nucleus upon which synthetic drugs can be produced. The selected and careful use of these plant products may definitely help in better wound management. Hence it is possible that, herbal remedies definitely hold hope for the discovery of potent prohealers.

Keywords

Wound Healing, Plant Products, Aloe vera, Lantana camara, Hypericum spp

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K. L. Bairy , A. Sharma , Adiga Shalini

Abstract

Objective: To study the effect of Syzygium malaccense on serum glucose, lipid profile and liver glycogen content in both normal and hyperglycemic rats. Methods: The aqueous and alcoholic extracts were compared with glibenclamide for their influence on fasting blood sugar, lipid profile and liver glycogen in both normoglycemic and to streptozotocin induced (50mg/kg ip) hyperglycemic rats. Results: In normoglycemic rats the aqueous and alcoholic extracts produced hypoglycemia but did not affect the lipid profile and liver glycogen content even on chronic treatment. In the hyperglycemic rats on chronic treatment both the extracts caused reduction in FBS and significantly reversed the diabetes induced hyperlipidemia and liver glycogen depletion. The alcoholic extract was found to be more active than aqueous and equivalent to that of glibenclamide. Conclusion: The extracts of Syzygium malaccense with their beneficial effects on blood sugar and hyperlipidemia associated with diabetes could serve as good adjuvant to other oral hypoglycemic agents.

Keywords

Syzygium malaccense, Hypoglycemic Activity, Lipid Profile

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K. L. Bairy , S. B. Ganesh , M. S. Adiga , A. Shalini

Abstract

Objective: To evaluate whether the extract of Ginkgo biloba (GB) could reverse the healing suppressant effect of Cyclophosphamide(CLP). Methods: The wound healing effects of CLP (12.6 mg/kg/ IP single dose on 3'd post wounding day) and GB (50 mg/kg IP) daily were tested on dead space and excision wound models in male rats. Results: CLP has significantly (p<0.05) reduced and GB has significantly(p<0.05) increased the breaking strength and hydroxyproline content of granulation tissue in dead space wounds. GB has significantly (p<0.01) reversed the suppressant effect of CLP. In case of excision wounds there was no change in wound contraction and epithelization period by CLP, GB or GB+CLP when compared to control. Conclusion: The healing suppressant effect of CLP was reversed by co-administration of GB. This effect of GB may due to its antioxidant property.

Keywords

Dead Space Wounds, Excision Wounds, Granulation Tissue, Hydroxyproline

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K. L. Bairy , C. M. Rao

Abstract

Objective: To evaluate the effects of Ginkgo biloba on wound healing. Materials and methods: The wound healing effects of dried extract of Ginkgo Biloba (GB) were tested at a dose of 50 mg/kg on dead space and excision wound models in male rats. Results: GB has significantly (p< 0.01) promoted the breaking strength and hydroxyproline content of granulation tissue in dead space wounds. In case of excision wounds while it did not affect the wound contraction, the epithelization period was significantly (p<0.01) shortened. Conclusion: GB exhibits a significant pro-healing activity, possibly by influencing the collagenation phase of wound healing.

Keywords

Ginkgo Biloba, Wound Healing, Dead Space Wound, Excision Wound, Granulation Tissue, Hydroxyproline

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