Journal of Natural Remedies

G. K. Dash , P. Suresh , S. Ganapaty

Abstract

Objective: To study the antihyperglycaemic and wound healing activity of the leaf extracts of Lantana camara Linn. on rats. Materials and methods: Antihyperglycaemic activity of the aqueous extract of the leaves was evaluated by using both normoglycaemic and alloxan induced hyperglycaemic rats. The wound healing activity was assessed for both leaf juice and hydroalcoholic (ethanol 50% v/v) extract of the leaves on excised rats. Results: The aqueous extract was found to produce significant reduction of blood glucose concentration between 2-4 h of administration in alloxan induced hyperglycaemic rats at tested dose levels. However, in normoglycaemic animals, the extract at 400mg/ kg produced significant reduction of blood glucose between 2-4 h of administration. In the wound healing studies, the leaf juice was found to be more active than the extract. Conclusion: In the light of the alarming toxicity of the plant, the use of this plant in whole or any part there of need to be carefully regulated until the toxic principles of the plant are identified and removed, to ensure a safe and effective treatment for diabetes.

Keywords

Lantana Camara Linn., Kondh Tribes, Alloxan, Antihyperglycaemic, Wound Healing

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T. Ghosh , T. K. Maity , A. Bose , G. K. Dash , M. Das

Abstract

Objective: To study the antimicrobial activity of the ethanolic extract of aerial parts of Bacopa monnieri Linn. Materials and methods: Minimum inhibitory concentration of the extract was performed by broth dilution method and the zone of inhibition was studied by agar disc diffusion method at concentrations of 2, 5 and 10 mg/ml in DMSO. Ciprofloxacin (5 μg/ml) and Cotrimazole (25 μg/ml) were used as reference controls for the antibacterial and antifungal studies respectively. Results: The results of MIC study revealed the antimicrobial activity of the extract against the tested strains of microorganisms between concentration ranges of 50 and 400 μg/ml. The results of zone of inhibition study revealed concentration dependant nature of the extract with better effectiveness against gram-positive bacteria than gram-negative bacteria. Conclusion: The present study indicates the potential usefulness of B. monnieri aerial parts in the treatment of various pathogenic diseases as mentioned in the Ayurvedic literature.

Keywords

Bacopa monnieri Linn., Antibacterial Activity, Antifungal Activity, Minimum Inhibitory Concentration, Zone of Inhibition

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G. K. Dash , Ch. P. Patro , A. K. Maiti

Abstract

Objective: To study the antihyperglycaemic activity of the ethanol (50% v/v) ischolar_main extract of Premna corymbosa Rottl. on albino rats. Materials and methods: Antihyperglycaemic activity of the ischolar_main extract was evaluated by using both normoglycaemic and alloxan induced hyperglycaemic rats at dose levels of 200 and 400 mg/kg respectively through oral route. Results: The extract was found to produce marked reduction in blood glucose concentration at tested dose levels in a dose dependant manner in both the models. However, in normoglycaemic animals, the extract at 400 mg/kg dose level produced significant reduction of blood glucose at the 8^th hour of administration. Conclusion: The results of the present study justify the use of the ischolar_mains of the plant for treating diabetes as suggested in folklore remedies.

Keywords

Premna corymbosa Rottl, Alloxan, Antihyperglycaemic, Normoglycaemic, Glibenclamide

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G. K. Dash , P. Suresh , S. K. Sahu , D. M. Kar , S. Ganapaty , S. B. Panda

Abstract

Objective: To study the anthelmintic and antimicrobial activities of the ethanolic extract of Evolvulus alsinoides Linn. Materials and methods: The anthelmintic activity was evaluated on adult Indian earthworm Pheretima posthuma due to its anatomical and physiological resemblance with the intestinal roundworm parasites of human beings. The antibacterial activity of the crude ethanolic extract was performed by agar cup plate method. Results: The ethanolic extract caused paralysis followed by death of the worms at all tested dose levels. It was observed that the ethanolic extract of Evolvulus alsinoides is more potent than the reference control piperazine citrate. Potency of the extract was inversely proportional to the time taken for paralysis/ death of the worms. The activity confirms the dose dependency nature of the extract. The results of antimicrobial activity revealed that the extract exhibited activity against Pseudomonas aeruginosa and Escherichia coli but inactive against Staphyloccus aureus and Candida albicans. None of test concentrations exhibited comparable activity with the reference control ampicillin trihydrate. Conclusion: The present study concludes that the plant is also endowed with potential anthelmintic property in addition to its other popular uses in the traditional system of medicine.

Keywords

Evolvulus alsinoides Linn., Anthelmintic, Antimicrobial, Piperazine Citrate, Ampicillin Trihydrate, Amphotericin B.

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