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Afifah, Ervi

Antioxidant and Anti Aging Assays of Oryza sativa Extracts, Vanillin and Coumaric Acid

Abstract Views :507 | PDF Views:300

Authors

Wahyu Widowati ¹, Nurul Fauziah ¹, Heddy Herdiman ¹, Merry Afni ², Ervi Afifah ², Hanna Sari W. Kusuma ², Hayatun Nufus ², Seila Arumwardana ², Dwi Davidson Rihibiha ²

Affiliations
1 Medical Research Center, Maranatha Christian University, Jl Prof Drg Surya Sumantri No 65 Bandung 40164, West Java, ID
2 Aretha Medika Utama, Biomolecular and Biomedical Research Center, Jl Babakan Jeruk 2, No 9, Bandung 40163, West Java, ID

Source

Journal of Natural Remedies, Vol 16, No 3 (2016), Pagination: 88-99

Abstract

Aging is a natural process in humans as accumulation of oxygen-derived free radicals which leads to the activation of hyaluronidase, collagenase and elastase, that can further contribute to cellular and tissue damage. Bioactive compounds from plants have been used as antioxidant that might inhibit aging processes as well. This study aimed to determine antioxidant and anti aging properties of Oryza sativa Extract (OSE), and its compounds, vanillin and coumaric acid. The phytochemical analysis of OSE was performed with Farnsworth modified method. Antioxidant activities were performed by measurement of 2,2-diphenyl 1-pichylhydazyl (DPPH) free radical scavenger, Ferric Reducing Antioxidant Power (FRAP), and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) reducing activity, while anti aging assay were observed through inhibitory of elastase, collagenase, and hyaluronidase activities. Phytochemical analysis showed the presence of terpenoids and saponins in high level. OSE showed lowest DPPH activity (IC₅₀ = 314.51 μg/mL) compared to vanillin (IC₅₀ = 283 μg/mL) and coumaric acid (IC₅₀ = 255.69 μg/mL). In ABTS assay, OSE resulted lowest activity(IC₅₀ = 145.67 μg/mL), compared to vanillin (IC₅₀ = 4.96 μg/mL) and coumaric acid (IC₅₀ = 1.67 μg/mL). OSE also showed the lowest FRAP-reducing activity (21.26 μM Fe(II)/μg), compared to vanillin (35.05 μM Fe(II)/μg) and coumaric acid (48.52μM Fe(II)/μg). OSE showed the lowest collagenase, elastase, and hyaluronidase inhibitory activity (IC₅₀ = 816.78,107.51, and 203.13 μg/mL), compared to vanillin (IC₅₀ = 16.27, 14.46, 45.23 μg/mL respectively) and coumaric acid (IC₅₀ = 146.89, 25.38, 8.21 μg/mL respectively). In summary, OSE possess the lowest antioxidant and anti aging activities compared to vanillin and coumaric acid.

Keywords

Antioxidant, Anti Aging, Coumaric Acid, Oryza sativa, Vanillin.

Full Text

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Mangosteen Peel Extract (Garcinia mangostana L.) and its Constituents to Lower Lipid Content on Adipogenesis Cells Model (3T3-L1)

Abstract Views :403 | PDF Views:189

Authors

Wahyu Widowati ¹, Lusiana Darsono ¹, Jo Suherman ¹, Ervi Afifah ², Rizal Rizal ², Yukko Arinta ², Rismawati Laila Qodariah ², Tjandrawati Mozef ³, Tri Suciati ⁴

Affiliations
1 Maranatha Christian University, Bandung - 40164, ID
2 Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung - 40163, ID
3 Research Center for Chemistry, Indonesian Institute of Sciences, Bandung, West Java, ID
4 Bandung Institute of Technology, Bandung, West Java, ID

Source

Journal of Natural Remedies, Vol 18, No 2 (2018), Pagination: 41-48

Abstract

Obesity is one of the risk factor for dyslipidemia incident, cancer, diabetes mellitus, and cardiovascular disease. Treatment of obesity using common commercial drugs shows low rate of success, hence natural products may provide better or more efficient therapeutic approach. Mangosteen (Garcinia mangostana L.) (Clusiaceae) peel extract contains xanthones and it is potentially used as alternative medicine for obesity. This research was done to determine the anti-obesity characteristics of Mangosteen Peel Extract (MPE) and its xanthones α-Mangostin (AM) and γ-Mangostin (GM) on 3T3L1 cell line. Anti-obesity effects of MPE and xanthones were investigated using differentiated-3T3L1 preadipocyte cells. Inhibitory activity of the extract and compounds on the production of Triglyceride (TG), Cholesterol (CHOL), Glucose-6-Phosphate Dehydrogenase (G6PDH) activity, and lipid droplets were examined. MPE and its compound were capable to inhibit the production of TG, CHOL, G6PDH, lipid droplets. MPE 50 μg/mL and GM 75 μM were the most active to lower TG 57.95% and 59.72%, CHOL 33.33% and 31.68%, G6PDH 52.90%, 41.95%, lipid droplets 72.99% and 70.07% respectively. In conclusion mangosteen peel extract and γ-Mangostin are the most active antiobesity compared to α-Mangostin.

Keywords

Glucose-6-Phosphate Dehydrogenase, Mangosteen, Obesity, Xanthones, 3T3-L1 Cells.

Full Text

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