Journal of Natural Remedies

S. B. Kasture , V. S. Kasture , A. J. Joshua , A. Damodaran , A. Amit

Abstract

The objective of this study was to evaluate the nootropic activity of BacoMind^TM, an enriched phytochemical composition from Bacopa monnieri, in different learning and memory paradigms viz., elevated plus maze, passive shock avoidance test and object recognition test. BacoMind^TM was administered for 7 days at the dose of 40, 60 and 80 mg/kg to mice in elevated plus maze and passive shock avoidance test and 27, 40 and 54 mg/kg to rats in object recognition test. Scopolamine (0.3 mg/kg) was used to induce amnesia and piracetam (100 mg/kg) served as reference standard. In elevated plus maze test, BacoMind^TM significantly (p<0.01) increased the inflexion ratio in scopolamine treated mice. In passive shock avoidance test, BacoMind^TM significantly (p<0.001) reduced the latency to reach the shock free zone and number of mistakes in 15 min in both normal as well as scopolamine treated mice. In object recognition test, BacoMind^TM significantly (p<0.001) increased the discrimination index in both normal as well as scopolamine treated rats. Thus, the findings of the present study revealed the nootropic activity of BacoMind^TM.

Keywords

, Bacopa monnieri, Nootropic Activity, Bacosides, Elevated Plus Maze, Passive Shock Avoidance Test, Object Recognition Test

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