Journal of Natural Remedies

Nitin Verma , R. L. Khosa , A. K. Pathak

Abstract

In the present study, wholesome tissue protective efficiency of the ethanolic extract of Tinospora cordifolia stems in mice in terms of whole body survival, genotoxicity, cell proliferation and hematological profile have been investigated. The animals were divided into four groups having six animals in each. Group I, (Control), received vehicle, Group II received orally ethanolic extract of Tinospora cordifolia (500mg/kg), Group III was irradiated with ⁶⁰Co radiation (external gamma radiation of 4 GY for 24h), and animals of Group IV were irradiated with ⁶⁰Co radiation (external gamma radiation of 4 GY for 24 h) and given orally ethanolic extract of Tinospora cordifolia (500mg/kg), for seven days. On the 8th day all the animals were sacrificed, the blood was collected and hematological cell profile was analyzed. Intestine was removed and its histopathology was done and their mitotic index and crypt of villi was counted. The drug shows significant tissue protective activity (P<0.05) and shows normalization in hematological cell profile in irradiated animals.

Keywords

Co Radiation

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Swati Dhote , P. Uma Devi , A. K. Pathak , R. B. Goswami

Abstract

Objective: To study the antigenotoxic effect of Piper betle leaves in Gamma irradiation and Cyclophosphamide treated animals. Materials and methods: Swiss albino mice were given 50% methanolic extract (100mg/kg body weight.) of Piper betle leaves and antigenotoxic effect was studied after whole body gamma irradiation (4Gy) & cyclophosphamide (50mg/kg body weight.) treatment. Bone marrow protection was studied by scoring aberration in metaphase chromosomes. Results: No drug toxicity was observed at given dose (100mg/kg body weight.) Methanol extract ½ hr prior to irradiation protects animals against Gamma irradiation & Cyclophosphamide treatment.

Keywords

Anti-genotoxic Activity, Piper betle, Gamma Irradiation, Cyclophosphamide

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Swati Dhote , P. Uma Devi , A. K. Pathak , R. B. Goswami

Abstract

Objective: To study the antigenotoxic effect of Piper betle leaves in Gamma irradiation and Cyclophosphamide treated animals. Materials and methods: Swiss albino mice were given 50% methanolic extract (100mg/kg body weight.) of Piper betle leaves and antigenotoxic effect was studied after whole body gamma irradiation (4Gy) & cyclophosphamide (50mg/kg body weight.) treatment. Bone marrow protection was studied by scoring aberration in metaphase chromosomes. Results: No drug toxicity was observed at given dose (100mg/kg body weight.) Methanol extract ½ hr prior to irradiation protects animals against Gamma irradiation & Cyclophosphamide treatment.

Keywords

Anti-genotoxic Activity, Piper betle, Gamma Irradiation, Cyclophosphamide

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