Journal of Natural Remedies

A. J. Joshua , D. R. Vinod , K. Pravina , R. S. Suja , K. S. Goudar , C. B. Pande , A. Amit

Abstract

The present study evaluates the lipotropic activity of Natchol, a polyherbal formulation, on carbon tetrachloride (CCl₄) induced fatty liver in male albino Wistar rats. Fatty liver was induced by intraperitoneal injection of CCl₄ at 0.1 ml/kg b.w. on 7^th and 8th day of treatment. Natchol was administered orally at 100 mg/kg b.w. while choline chloride was given at the dose of 200 mg/kg b.w. for seven days prior to CCl₄ treatment. The administration of Natchol and choline chloride was continued till 72 hours after the second dose of CCl₄. Natchol treatment significantly reduced (p≤0.05) the hepatic triglycerides level and ameliorated the reduction in weight gain induced by CCl₄. The histopathological examination of liver further corroborated the lipotropic activity of Natchol and it was found to be comparable with that of choline chloride, the positive control. Thus the present study revealed the lipotropic effect of Natchol in hepatic steatosis.

Keywords

Lipotropic Activity, Choline Chloride, Natchol, Solanum nigrum, Citrullus colocynthis, Bacopa monnieri, Sida cordifolia, Boerhaavia diffusa

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S. B. Kasture , V. S. Kasture , A. J. Joshua , A. Damodaran , A. Amit

Abstract

The objective of this study was to evaluate the nootropic activity of BacoMind^TM, an enriched phytochemical composition from Bacopa monnieri, in different learning and memory paradigms viz., elevated plus maze, passive shock avoidance test and object recognition test. BacoMind^TM was administered for 7 days at the dose of 40, 60 and 80 mg/kg to mice in elevated plus maze and passive shock avoidance test and 27, 40 and 54 mg/kg to rats in object recognition test. Scopolamine (0.3 mg/kg) was used to induce amnesia and piracetam (100 mg/kg) served as reference standard. In elevated plus maze test, BacoMind^TM significantly (p<0.01) increased the inflexion ratio in scopolamine treated mice. In passive shock avoidance test, BacoMind^TM significantly (p<0.001) reduced the latency to reach the shock free zone and number of mistakes in 15 min in both normal as well as scopolamine treated mice. In object recognition test, BacoMind^TM significantly (p<0.001) increased the discrimination index in both normal as well as scopolamine treated rats. Thus, the findings of the present study revealed the nootropic activity of BacoMind^TM.

Keywords

, Bacopa monnieri, Nootropic Activity, Bacosides, Elevated Plus Maze, Passive Shock Avoidance Test, Object Recognition Test

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