Effect of Achillea millefolium Extract in Wound Healing of Rabbit

Objective: To evaluate the effect of hydroalcoholic extract of Achillea millefolium (yarrow) on the wound healing in rabbit. Material and methods: Wound healing effect of yarrow extract in eucerin base at concentrations of 2, 5 and 10% w/w were tested topically on full thickness excision wound in rabbits. Such effect was compared with phenytoin cream (1%) as a standard healing agent. Results: Yarrow extract creams significantly reduced the rate of wound healing compared to no-treatment, eucerin. Five percent yarrow extract cream showed better healing profile, and the rate of healing was significantly (p<0.01) better than other groups. Conclusion: Yarrow showed a considerable potential for wound healing possibly by accelerating the collagenation and proliferation phase of wound healing.