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Evaluation of Anti-ulcer Activity of Rosa centifolia (Linn.) Flowers in Experimental Rats


 

The present study was carried out to investigate antiulcer activity of various solvent extracts of Rosa Centifolia (Linn.) flowers in different ulcer models like pyloric ligation, indomethacin, ethanol and cold restraint stress induced ulcer models of rats. In pylorus ligation model, various parameters were studied viz. volume and pH of gastric juice, total acidity, free acidity, ulcer score, ulcer index and percentage protection was determined. Ulcer score, ulcer index and percentage inhibition of ulceration was determined for other ulcer models. Pantoprazole (8 mg/kg p.o.) was used as the standard drug. Pretreatment with the extracts (400 mg/kg p.o.) showed significant protection against four different ulcer models. In pylorus ligated model, all the extracts showed significant decrease in the volume of gastric juice, free and total acidity, ulcer score, ulcer index and increase in pH of gastric juice, while in other models, there was significant decrease in ulcer score and ulcer index as compared to the toxicant control group. In conclusion, Rosa Centifolia (Linn.) flowers possess significant anti-ulcer and cytoprotective effect.

Keywords

Rosa centifolia, Anti-ulcer, Pylorus Ligation, Ulcer Index
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  • Evaluation of Anti-ulcer Activity of Rosa centifolia (Linn.) Flowers in Experimental Rats

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Abstract


The present study was carried out to investigate antiulcer activity of various solvent extracts of Rosa Centifolia (Linn.) flowers in different ulcer models like pyloric ligation, indomethacin, ethanol and cold restraint stress induced ulcer models of rats. In pylorus ligation model, various parameters were studied viz. volume and pH of gastric juice, total acidity, free acidity, ulcer score, ulcer index and percentage protection was determined. Ulcer score, ulcer index and percentage inhibition of ulceration was determined for other ulcer models. Pantoprazole (8 mg/kg p.o.) was used as the standard drug. Pretreatment with the extracts (400 mg/kg p.o.) showed significant protection against four different ulcer models. In pylorus ligated model, all the extracts showed significant decrease in the volume of gastric juice, free and total acidity, ulcer score, ulcer index and increase in pH of gastric juice, while in other models, there was significant decrease in ulcer score and ulcer index as compared to the toxicant control group. In conclusion, Rosa Centifolia (Linn.) flowers possess significant anti-ulcer and cytoprotective effect.

Keywords


Rosa centifolia, Anti-ulcer, Pylorus Ligation, Ulcer Index