Journal of Natural Remedies

Open Access Open Access  Restricted Access Subscription Access

Protective Effects of Fagonia cretica L. Extract in Cafeteria Diet Induced Obesity in Wistar Rats


Affiliations
1 Institute of Pharmacy, Nirma University, Ahmedabad - 382481, Gujarat, India
2 ITM School of Pharmacy, ITM Universe, Paldi, Vadodara - 391510, Gujarat, India
 

Obesity is one of the major life style disorders which may lead to undesirable effects on cholesterol, triglycerides, blood pressure and insulin resistance and eventually increases the risk of various adverse conditions like ischemic heart disease, stroke, coronary artery disease & type 2 diabetes. The present investigation was undertaken to explore protective effects of aerial parts of Fagonia cretica L. extract in cafeteria diet induced obesity in Wistar rats. Female Wistar rats were provided with cafeteria diet (CD) for the period of 10 weeks to induce obesity. Fagonia cretica L. methanolic extracts (200 & 400 mg/kg) & standard drug orlistat (30 mg/kg) were administered for last 6 weeks along with the continuation of CD. Various primary metabolic indicators of obesity like daily food consumption, body weight, lipid profile, fecal fat content & fat pads were studied. Administration of methanolic extract of Fagonia cretica L. significantly stopped increase in daily food consumption & body weight gain as compared to obese control group. Improvement in lipid profile was also observed in the all treatment groups rats as compared to obese control group rats. Obtained results validate that supplementation of Fagonia cretica L. methanolic extracts in obese rats resulted in significant protection against various indicators of obesity.

Keywords

Cafeteria Diet, Fagonia cretica L. Lipid Profile, Obesity.
Font Size

User

Notifications
JOURNAL COVERS
  

  • Verma R, Paraidathathu T. Herbal medicines used in the traditional Indian medicinal system as a therapeutic treatment option for overweight and obesity management: A review. International Journal of Pharmacy and Pharmaceutical Sciences. 2014; 6(2): 40-47.

  • Abdollahi M, Imani B. A review on obesity and weight loss measures. Middle East Pharmacy. 2003; 11:6-10.

  • Trivedi PC. Medicinal Plants Utilization & Conservation. Jaipur: Aavishkar Publication; 2009.

  • Khare CP. Indian Herbal Remedies. New York: Springer; 2004. https://doi.org/10.1007/978-3-642-18659-2

  • Ahmad SS. Medicinal wild plants from Lahore-Islamabad motorway (M-2). Pakistan Journal of Botany. 2007; 39:35575.

  • Marwat SK, Khan MA, Ahmad M, Zafar M, Rehman FU. Ethnophytomedicines for treatment of various diseases in D.I.Khan district sarhad. Journal of agricultural research. 2008; 24:305-15.

  • Sajid B, Alia E, Rizwana K, Uzma S, Alamgeer, Hafiz MI. Phytochemical screening and antimicrobial activity of Fagonia cretica plant extracts against selected microbes. Journal of Pharmacy Research. 2011; 4:962-63.

  • Dastagir G, Hussain F, Khan AA. Antibacterial activity of some selected plants of family Zygophyllaceae and Euphorbiaceae. Journal of Medicinal Plant Research. 2012; 6: 5360-68. https://doi.org/10.5897/JMPR12.539

  • Ali SS, Kasoju N, Luthra A, Singh A, Hallihosur S, Shahu A. Indian Medicinal plants as source of antioxidants, Food Research International. 2008; 41:1-15. https://doi.org/10.1016/j.foodres.2007.10.001

  • Hussain A, Zia M, Mirza B. Cytotoxic and antitumor potential of Fagonia cretica L. Turkish Journal of Biology. 2007; 31:19-24.

  • Sharma S, Joseph L, George M, Gupta V. Analgesic and antimicrobial activity of Fagonia indica. Pharmacology online. 2009; 3:623-632.

  • Eldin HS., Gadir HA., Hassan AW. Evaluation of the hepatoprotective activity of Fagonia cretica L., Research & Review: Journal of Pharmacognosy & Phytochemistry 2015; 3:1-6.

  • Anjum MI, Ahmed E, Jabbar A, Malik A, Ashraf M, Moazzam M. Antimicrobial constituents from Fagonia cretica. Journal of the Chemical Society of Pakistan. 2007; 6:634-39.

  • Abhirami V, Khosa RL, Dhar SK, Sahai M. Investigation on Fagonia cretica-Its effect on hormonal profile and immunomodulation in rats. Ancient Science of Life. 1996; 15:4: 259- 63.

  • Anonymous. Ayurvedic Pharmacopoeia of India. Part I. New Delhi; Ministry of Health and Family Welfare; 2001.

  • Kamalakkannan S, Rajendran R, Venkatesh RV, Clayton P, Akbarsha MA. Anti-obesogenic and anti-atherosclerotic properties of Caralluma fimbriata extract. Journal of Nutrition & Metabolism. 2010; 285301. https://doi.org/10.1155/2010/285301 PMid:21234320 PMCid:PMC3018644

  • Harris RB. The impact of high or low-fat cafeteria foods on nutrient intake and growth of rats consuming a diet containing 30% energy as fat. International Journal of Obesity and Related Metabolic Disorders. 1993; 17(6):307-15.

  • Schwarz M, Lund EG, Setchell KD, Kayden HJ, Zerwekh JE, Björkhem I, Herz J, Russell DW. Disruption of Cholesterol 7α-Hydroxylase Gene in Mice II. Bile acid deficiency is overcome by induction of Oxysterol 7α- Hydroxylase. Journal of Biological Chemistry. 1996; 271(30): 18024-31. https://doi.org/10.1074/jbc.271.30.18024 PMid:8663430 PMCid:PMC4451191

  • Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology. New Delhi: Elsevier; 2003.

  • Gomez-Smith M, Karthikeyan S, Jeffers MS, Janik R, Thomason LA, Stefanovic B, Corbett D. A physiological characterization of the Cafeteria diet model of metabolic syndrome in the rat. Physiology & Behavior. 2016; 167:382-91. https://doi.org/10.1016/j.physbeh.2016.09.029 PMid:27705750

  • Oliva L, Aranda T, Caviola G, Fernández-Bernal A, Alemany M, Fernández-López JA, Remesar X. In rats fed high-energy diets, taste, rather than fat content, is the key factor increasing food intake: a comparison of a cafeteria and a lipid- supplemented standard diet. Peer J. 2017; 5: e3697. https://doi.org/10.7717/peerj.3697 PMid:28929011 PMCid:PMC5600723


Abstract Views: 292

PDF Views: 134




  • Protective Effects of Fagonia cretica L. Extract in Cafeteria Diet Induced Obesity in Wistar Rats

Abstract Views: 292  |  PDF Views: 134

Authors

Divyang Patel
Institute of Pharmacy, Nirma University, Ahmedabad - 382481, Gujarat, India
Vimal Kumar
ITM School of Pharmacy, ITM Universe, Paldi, Vadodara - 391510, Gujarat, India

Abstract


Obesity is one of the major life style disorders which may lead to undesirable effects on cholesterol, triglycerides, blood pressure and insulin resistance and eventually increases the risk of various adverse conditions like ischemic heart disease, stroke, coronary artery disease & type 2 diabetes. The present investigation was undertaken to explore protective effects of aerial parts of Fagonia cretica L. extract in cafeteria diet induced obesity in Wistar rats. Female Wistar rats were provided with cafeteria diet (CD) for the period of 10 weeks to induce obesity. Fagonia cretica L. methanolic extracts (200 & 400 mg/kg) & standard drug orlistat (30 mg/kg) were administered for last 6 weeks along with the continuation of CD. Various primary metabolic indicators of obesity like daily food consumption, body weight, lipid profile, fecal fat content & fat pads were studied. Administration of methanolic extract of Fagonia cretica L. significantly stopped increase in daily food consumption & body weight gain as compared to obese control group. Improvement in lipid profile was also observed in the all treatment groups rats as compared to obese control group rats. Obtained results validate that supplementation of Fagonia cretica L. methanolic extracts in obese rats resulted in significant protection against various indicators of obesity.

Keywords


Cafeteria Diet, Fagonia cretica L. Lipid Profile, Obesity.

References





DOI: https://doi.org/10.18311/jnr%2F2020%2F25223