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Concepts of Prakriti (Human Constitution) and its Association with Hematological Parameters, Body Mass Index (BMI), Blood Groups and Genotypes


Affiliations
1 Department of Kaumarbhritya /Bal-roga, Government Ayurvedic P.G College and Hospital, Varanasi – 221001 (Sampurnanand Sanskrit University), Uttar Pradesh, India
2 Department of Shalya tantra, Uttarakhand Ayurved University (Main Campus), Harrawala, Dehradun – 248001, Uttarakhand, India
 

Background: Ayurveda is an ancient system of personalized medicine, documented and practiced in India since 1500 B.C. According to this system an individual’s basic constitution to a large extent determines predisposition and prognosis to diseases as well as the therapy and life-style regime. Ayurveda describes seven broad Prakriti (Physical constitution) Prakriti is defined as the sum of physical, physiological, psychological traits of an individual which represents genotypes. Objective: In this article we have attempted to narrate concepts of Prakriti and its relation with hematological parameter, body mass index, blood groups and genotypes. Material and Method: Present article is based on critical review of Ayurvedic textual information, published research works, modern literature and research works conducted at various institutes. The possible correlation has been made between collected information and has been presented in systematic way. Result: In Pitta Prakriti individual’s hematological parameters like Hemoglobin (Hb%), Packed cell volume (PCV), and Red blood corpuscles (RBC) count are significantly on the higher side of normal range in comparison to Vata and Kapha Prakriti. Higher level of cluster of differentiation (CD) 14 markers in Pitta Prakriti, CD25 and CD56 in Kapha Prakriti individuals. Vata Prakriti individuals have “A” blood group, maximum Pitta Prakriti individuals have “O” blood group while maximum Kapha Prakriti individuals have “B” blood group and genotype correlation shows that HLA DRB1 ((human leukocyte antigen, dimer beta chain) gene polymorphism, CYP2C19 (Cytochrome P450 2C19) gene polymorphism and PGM1 (Phosphoglucomutase 1) polymorphism have scientific variations with the human Prakriti concept. Conclusion: Prakritiof individual has strong relation with Hematological parameters (CBC, lipid profile, Liver function test (LFT)), Body mass index (BMI), anthropometry, blood groups and genotypes.

 


Keywords

Body Mass Index, Blood Groups, Constitution, Hematological Parameters, Prakriti.
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  • Hankey A. A test of the systems analysis underlying the scientific theory of Ayurveda’s Tridosha. Journal of Alternative and Complementary Medicine. 2005; 11:385–90. https://doi.org/10.1089/acm.2005.11.385. PMid:15992219
  • Kim JY, Pham DD, Koh BH. Comparison of Sasang constitutional medicine, traditional chinese medicine and Ayurveda. Evidence Based Complement Alternative Medicine. 2011; 2011. https://doi.org/10.1093/ecam/neq052. PMid:21949669 PMCid:PMC3143585
  • Patwardhan B, Warude D, Pushpangadan P, Bhatt N. Ayurveda and traditional Chinese medicine: A comparative overview. Evidence-Based Complementary and Alternative Medicine. 2005; 2:465–74. https://doi.org/10.1093/ecam/neh140. PMid:16322803 PMCid:PMC1297513
  • Agnivesha. Charaka samhita, English translation by Sharma RK, Dash B. Vol-1, Sutra Sthan (30:26), Chaukhambha Sanskrit series office, Varanasi; 2010.
  • Singh D, Gehlot S, Singh BM, Rai DC. Variations of human milk compositions as per Prakriti (Psychosomatic Constitution): A Pilot Study. Journal of Natural Remedies. 2019 Jul; 19(3). https://doi.org/10.18311/jnr/2019/23395
  • Agnivesha. Charaka samhita, English translation by Sharma RK, Dash B. Vol-1, Viman Sthan (6/16), Chaukhambha Sanskrit series office, Varanasi; 2010.
  • Agnivesha. Charaka samhita, English translation by Sharma RK, Dash B. Vol-1, Sutra Sthan (10:11), Chaukhambha Sanskrit series office, Varanasi; 2010.
  • Vagbhata. Astanga Hridayam, English translation by Srikantha Murty KR, Vol-I, Sutra sthana (1:10), Chaukhambha, Krishnadas Academy Varanasi; 2015.
  • Agnivesha. Charaka samhita, English translation by Sharma RK, Dash B. Vol-1, Viman Sthan (8:95), Chaukhambha Sanskrit series office, Varanasi; 2010.
  • Agnivesha. Charaka samhita, English translation by Sharma RK, Dash B. Vol-1, Sutra Sthan (1/12), Chaukhambha Sanskrit series office, Varanasi; 2010.
  • Vagbhata. Astanga samgraha, English translation by Srikantha Murty KR, Vol-I, Sutra Sthana, (19/20), Chaukhambha Orientalia, Varanasi; 2001.
  • Agnivesha. Charaka samhita, English translation by Sharma RK, Dash B. Vol-1, Viman-Sthan (8:95), Chaukhambha Sanskrit series office, Varanasi; 2010.
  • Agnivesha. Charaka samhita, English translation by Sharma RK, Dash B. Vol-II, Indriya Sthan (1:5), Chaukhambha Sanskrit series office, Varanasi; 2010.
  • Agnivesha. Charaka samhita, English translation by Sharma RK, Dash B. Vol-II, Viman-Sthan (8:94), Chaukhambha Sanskrit series office, Varanasi; 2010.
  • Sushruta. Sushruta samhita, English translation by Sharma P.V, Vol II, Sharir-sthan (4:62), Chaukhambha Vishvabharati, Varanasi; 2005.
  • Vagbhata. Astanga Hriday , English translation by Srikantha Murty KR, Vol-II, Sharir sthana (8:3), Chaukhambha, Krishnadas Academy Varanasi; 2015.
  • Vagbhata .Astanga Hriday , English translation by Srikantha Murty KR, Vol-II, Sharir sthana (3:83) Chaukhambha, Krishnadas Academy Varanasi; 2015.
  • Agnivesha. Charaka samhita, English translation by Sharma RK, Dash B. Vol-II, Viman-Sthan (8:96), 98 Chaukhambha Sanskrit series office, Varanasi; 2010.
  • Sushruta. Sushruta samhita, English translation by Sharma P.V, Vol II, Sharir-sthan (4:66), Chaukhambha Vishvabharati, Varanasi; 2005.
  • Vagbhata .Astanga Hriday , English translation by Srikantha Murty KR, Vol-II, Sharir sthana (3:84-103) Chaukhambha, Krishnadas Academy Varanasi; 2015.
  • Sharangadharacarya. Sharngadhar samhita English translation by Rao G. Prabhakar, 1st edition, Purvakhanda (6:20-22), pg- 32-33, Chaukhambha Sanskrit sansthan, Varanasi; 2013.
  • Harita samhita English translation by Pandey Gyanendra, Vol-1, Pratham sthana 5:17-22, pg 32-33, Chaukhambha Sanskrit series office, Varanasi; 2016.
  • Mukerji M, Prasher B. Ayurgenomics: A new approach in personalized and preventive medicine. Scientific Culture. 2011; 77:10–7.
  • Sethi TP, Prasher B, Mukerji M. Ayurgenomics: A new way of threading molecular variability for stratified medicine. ACS Chemical Biology. 2011; 6:875–88. https://doi.org/10.1021/cb2003016. PMid:21923095
  • Patwardhan B, Mashelkar RA. Traditional medicineinspired approaches to drug discovery: Can Ayurveda show the way forward? Drug Discovery Today. 2009; 14:804–11. https://doi.org/10.1016/j.drudis.2009.05.009. PMid:19477288
  • Sushruta. Sushruta samhita, English translation by Sharma P.V, Vol II, Sharir sthan (4:77), Chaukhambha Vishvabharati, Varanasi; 2005.
  • Dey S, Pahwa P. Prakriti and its associations with metabolism, chronic diseases, and genotypes: Possibilities of new born screening and a lifetime of personalized, prevention. Journal of Ayurveda and Integrative Medicine. 2014; 5:15–24. https://doi.org/10.4103/0975-9476.128848. PMid:24812471 PMCid:PMC4012357
  • Niraj S, Sangeeta G, Singh BM. Affiliation among Infantile Age, Morbidity and Prakriti (Physical Constitution): A Longitudinal Preliminary Study. 2019; 19(1). https://doi.org/10.18311/jnr/2019/23286
  • Sushruta. Sushruta samhita, English translation by Sharma PV, Vol I, Sutra Sthan (10:4), Chaukhambha Vishvabharati, Varanasi; 2005.
  • Vagbhata. Astanga samgraha, English translation by Srikantha Murty KR, Vol-I, Sutra Sthana, (1/45.1), Chaukhambha Orientalia, Varanasi; 2001.
  • Niraj S, Singh P, Sangeeta G, Singh S, Singh BM. Basics for the development of prototype research software relevant to infants’ Prakriti assessment for Vikriti management and possible future disorders. International Journal of Research in Ayurveda and Pharmacy. 2017; 8(Suppl 1). https://doi.org/10.7897/2277-4343.08139
  • Prasher B, Negi S, Aggarwal S, Mandal AK, Sethi TP, Deshmukh SR, et al. Brahmachari SK: Indian genome variation consortium, Mukerji M; ‘Whole genome expression and biochemical correlates of extreme constitutional types defined in Ayurveda’. Journal of Translational Medicine. 2008, 6:48. https://doi.org/10.1186/1479-5876-6-48. PMid:18782426 PMCid:PMC2562368
  • Tiwari S, Gehlot S, Tiwari SK, Singh G: Effect of walking (aerobic isotonic exercise) on physiological variants with special reference to Prameha (diabetes mellitus) as per Prakriti; AYU. 2012; 33(1):44–9. https://doi.org/10.4103/0974-8520.100308. PMid:23049183 PMCid:PMC3456862
  • Khatri M, Sharma US. A comparative study of changes in lipid profile in different age groups w.s.r. Prakriti. International Journal of Ayurveda and Pharma Research. 2013; 1(2):31–7.
  • Kavita P, Sangeeta G, Kamlakar T. Effect of aerobic exercise on Anthroprometric and metabolic parameters in Obese type-2 Diabetics with reference to Specific body constitution (Prakriti). International Journal of Research in Ayurveda and Pharmacy. 2012; 3(5):659–63 https://doi.org/10.7897/2277-4343.03516
  • Rotti H, Raval R, Anchan S, Bellampalli R, Bhale S, Bharadwaj R, et al. Determinants of Prakriti, the human constitution types of Indian traditional medicine and its correlation with contemporary science. Journal of Ayurveda and Integrative Medicine. 2014; 5:167–75. https://doi.org/10.4103/09759476.140478. PMid:25336848 PMCid:PMC4204287
  • Srivastava N, Gehlot S, Singh S, Singh BM. Do the anthropometric parameters vary as per Prakriti (Physical constitution) of Infants. International Journal of Innovative Knowledge Concepts. 2017 Dec; 5(12).
  • Landsteiner K, Wiener AS. An agglutinable factor in human blood recognized by immune sera for rhesus blood. In Rhesus haemolytic disease (pp. 41-42). Springer, Dordrecht; 1940. https://doi.org/10.1007/978-94-011-6138-1_3
  • Rotti H, Raval R, Anchan S, Bellampalli R, Bhale S, Bharadwaj R, et al. Determinants of Prakriti, the human constitution types of Indian traditional medicine and its correlation with contemporary science. Journal of Ayurveda and Integrative Medicine. 2014; 5:167–75. https://doi.org/10.4103/09759476.140478. PMid:25336848 PMCid:PMC4204287
  • Niraj S, Sangeeta G, Sanjay S, Singh BM. Association of Prakriti and Blood Groups of Infants in respect to Blood groups of Parents. International Journal of Innovative Knowledge Concepts; 2018 Jul; 6(7).
  • Agusti A. Phenotypes and disease characterization in chronic obstructive pulmonary disease: Toward the extinction of phenotypes? Annals of the American Thoracic Society. 2013; 10 suppl.:S125–S130. https://doi.org/10.1513/AnnalsATS.201303-055AW. PMid:24313762
  • Hood L, Friend SH. Predictive, personalized, preventive, participatory (P4) cancer medicine. Nature Reviews Clinical Oncology. 2011; 8:184–7. https://doi.org/10.1038/nrclinonc.2010.227. PMid:21364692
  • Tian Q, Price N, Hood L. 2012 systems cancer medicine: Towards realization of predictive, preventive, personalized and participatory (P4) medicine. Journal of Internal Medicine. 271; 111–21. https://doi.org/10.1111/j.13652796.2011.02498.x. PMid:22142401 PMCid:PMC3978383
  • Gupta P. Pharmacogenetics, pharmacogenomics and ayurgenomics for personalized medicine: A paradigm shift. Indian Journal of Pharmaceutical Sciences. 2015; 77:135–41. https://doi.org/10.4103/0250-474X.156543. Mid:26009644 PMCid:PMC4442460
  • Juyal RC, Negi S, Wakhode P, Bhat S, Bhat B, Thelma BK. Potential of ayurgenomics approach in complex trait research: Leads from a pilot study on rheumatoid arthritis. PLoS One. 2012; 7. https://doi.org/10.1371/journal.pone.0045752. PMid:23049851 PMCid:PMC3458907
  • Govindaraj P, Nizamuddin S, Sharath A, Jyothi V, Rotti H, Raval R, et al. Genome-wide analysis correlates Ayurveda prakriti. Scientific Reports. 2015; 5:15786. https://doi.org/10.1038/srep15786. PMid:26511157 PMCid:PMC4625161
  • Bhushan P, Kalpana J, Arvind C. Classification of human population based on HLA Gene polymorphism and the concept of Prakriti in Ayurveda. Journal of Alternative and Complementary Medicine. 2005; 11:349–53. https://doi.org/10.1089/acm.2005.11.349. PMid:15865503
  • Ghodke Y, Joshi K, Patwardhan B. Traditional medicine to modern pharmacogenomics: Ayurveda prakriti type and CYP2C19 gene polymorphism associated with the metabolic variability. Evidence-Based Complementary and Alternative Medicine. 2011; 2011. https://doi.org/10.1093/ecam/nep206. PMid:20015960 MCid:PMC3135904
  • Ayosoft: A decision support system for ayurveda, developed by C-DAC [Internet]. [cited 12 May 2016]. Available from: http://www.cdac.in/index.aspx?id¼hi_dss_ayusoft.
  • Niraj S, Singh P, Sangeeta G, Singh S, Singh BM. Basics for the development of prototype research software relevant to infants’ Prakriti assessment for Vikriti management and possible future disorders. International Journal of Research in Ayurveda and Pharmacy. 2017; 8(Suppl 1). https://doi.org/10.7897/2277-4343.08139
  • Tripathi JS, Singh RH. Concept of Deha Prakriti vis-a-vis human constitution in Ayurveda. Ancient Sci Life. 1994; 13:314–25.
  • Rotti H, Guruprasad KP, Nayak J, Kabbekkodu SP, Kukreja H, Mallya S, et al. Immunophentyping of normal individuals classified on the basis of human Dosha Prakriti. Journal of Ayurveda and Integrative Medicine. 2014; 5:43–9. https:// doi.org/10.4103/0975-9476.128857. PMid:24812475 PMCid:PMC4012362

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  • Concepts of Prakriti (Human Constitution) and its Association with Hematological Parameters, Body Mass Index (BMI), Blood Groups and Genotypes

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Authors

Niraj Srivastava
Department of Kaumarbhritya /Bal-roga, Government Ayurvedic P.G College and Hospital, Varanasi – 221001 (Sampurnanand Sanskrit University), Uttar Pradesh, India
Varsha Saxena
Department of Shalya tantra, Uttarakhand Ayurved University (Main Campus), Harrawala, Dehradun – 248001, Uttarakhand, India

Abstract


Background: Ayurveda is an ancient system of personalized medicine, documented and practiced in India since 1500 B.C. According to this system an individual’s basic constitution to a large extent determines predisposition and prognosis to diseases as well as the therapy and life-style regime. Ayurveda describes seven broad Prakriti (Physical constitution) Prakriti is defined as the sum of physical, physiological, psychological traits of an individual which represents genotypes. Objective: In this article we have attempted to narrate concepts of Prakriti and its relation with hematological parameter, body mass index, blood groups and genotypes. Material and Method: Present article is based on critical review of Ayurvedic textual information, published research works, modern literature and research works conducted at various institutes. The possible correlation has been made between collected information and has been presented in systematic way. Result: In Pitta Prakriti individual’s hematological parameters like Hemoglobin (Hb%), Packed cell volume (PCV), and Red blood corpuscles (RBC) count are significantly on the higher side of normal range in comparison to Vata and Kapha Prakriti. Higher level of cluster of differentiation (CD) 14 markers in Pitta Prakriti, CD25 and CD56 in Kapha Prakriti individuals. Vata Prakriti individuals have “A” blood group, maximum Pitta Prakriti individuals have “O” blood group while maximum Kapha Prakriti individuals have “B” blood group and genotype correlation shows that HLA DRB1 ((human leukocyte antigen, dimer beta chain) gene polymorphism, CYP2C19 (Cytochrome P450 2C19) gene polymorphism and PGM1 (Phosphoglucomutase 1) polymorphism have scientific variations with the human Prakriti concept. Conclusion: Prakritiof individual has strong relation with Hematological parameters (CBC, lipid profile, Liver function test (LFT)), Body mass index (BMI), anthropometry, blood groups and genotypes.

 


Keywords


Body Mass Index, Blood Groups, Constitution, Hematological Parameters, Prakriti.

References





DOI: https://doi.org/10.18311/jnr%2F2019%2F23584