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Comparative Study on Myelotoxic and Antineoplastic Action of Synadenium umbellatum, Vitis vinifera and Resveratrol


Affiliations
1 Laboratorio de Analises Clínicas da, Av Principe de Gales, 821, CEP 09060-650 Santo Andre, Sao Paulo, Brazil
2 Departamento de Ciencias Farmaceuticas da Universidade Federal de Sao Paulo, Diadema, Sao Paulo, Brazil
3 Departamento de Farmacologia da Farmaceuticas da UNICAMP, Campinas, Sao Paulo, Brazil
 

Cancer is one of the pathologies that most challenge medicine, not only because of the complexity of its development, but also because of the difficulty of treatment that is not always effective. Due to the significant toxicity and adverse effects profile presented by the main chemotherapeutic agents used to treat neoplasm, there is a constant interest in the search for new drugs that may be a more effective alternative. Therefore, the search for new compounds of plant origin becomes an interesting tool for the discovery of drugs with antitumor activity. Synadenium umbellatum is a plant native to tropical Africa known as “cola-nota”, “hazel”, “cancerous”, “miraculous”, among others. The plant is used by the Brazilian population as having anti-inflammatory, analgesic, antineoplastic properties, among others. However, the literature is lacking on reports of the toxicity of Synadenium umbellatum macerate. Resveratrol is a polyphenolic compound found in different plant species, mainly in grape species (Vitis) and their seeds. Vitis vinifera is a species of grape easily found in several regions, also containing a high concentrations of phenolic compounds, including resveratrol in its fruits, leaves and seeds. Therefore, this study was aimed to evaluate the myelotoxicity of macerate, extract and resveratrol and their antitumor activity in Balb/c mice with Ehrlich tumor. The hematological evaluation was obtained by flow cytometry and the tumors were measured using a pachymeter and the tumor masses by means of weighing. No statistically significant difference was observed between results from the control group and the treatment groups. It was concluded that macerate, crude extract and resveratrol did not demonstrate a myelotoxic effect and did not cause a decrease in tumor mass.

Keywords

Antineoplastics, Drug Toxicity, Phytotherapy.
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  • Comparative Study on Myelotoxic and Antineoplastic Action of Synadenium umbellatum, Vitis vinifera and Resveratrol

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Authors

Emerson B. da Silva
Laboratorio de Analises Clínicas da, Av Principe de Gales, 821, CEP 09060-650 Santo Andre, Sao Paulo, Brazil
Camila S. Chagas
Departamento de Ciencias Farmaceuticas da Universidade Federal de Sao Paulo, Diadema, Sao Paulo, Brazil
Marina P. A. Oliveira
Departamento de Ciencias Farmaceuticas da Universidade Federal de Sao Paulo, Diadema, Sao Paulo, Brazil
Alexandre L. A. Fonseca
Laboratorio de Analises Clínicas da, Av Principe de Gales, 821, CEP 09060-650 Santo Andre, Sao Paulo, Brazil
Beatriz da C. A. Alves
Laboratorio de Analises Clínicas da, Av Principe de Gales, 821, CEP 09060-650 Santo Andre, Sao Paulo, Brazil
Izilda Bagatin
Departamento de Ciencias Farmaceuticas da Universidade Federal de Sao Paulo, Diadema, Sao Paulo, Brazil
Fabio F. Perazzo
Departamento de Ciencias Farmaceuticas da Universidade Federal de Sao Paulo, Diadema, Sao Paulo, Brazil
Paulo Rosa
Departamento de Farmacologia da Farmaceuticas da UNICAMP, Campinas, Sao Paulo, Brazil
David Feder
Laboratorio de Analises Clínicas da, Av Principe de Gales, 821, CEP 09060-650 Santo Andre, Sao Paulo, Brazil
Giuliana Petri
Laboratorio de Analises Clínicas da, Av Principe de Gales, 821, CEP 09060-650 Santo Andre, Sao Paulo, Brazil
Fernando Luiz A. Fonseca
Laboratorio de Analises Clínicas da, Av Principe de Gales, 821, CEP 09060-650 Santo Andre, Sao Paulo, Brazil

Abstract


Cancer is one of the pathologies that most challenge medicine, not only because of the complexity of its development, but also because of the difficulty of treatment that is not always effective. Due to the significant toxicity and adverse effects profile presented by the main chemotherapeutic agents used to treat neoplasm, there is a constant interest in the search for new drugs that may be a more effective alternative. Therefore, the search for new compounds of plant origin becomes an interesting tool for the discovery of drugs with antitumor activity. Synadenium umbellatum is a plant native to tropical Africa known as “cola-nota”, “hazel”, “cancerous”, “miraculous”, among others. The plant is used by the Brazilian population as having anti-inflammatory, analgesic, antineoplastic properties, among others. However, the literature is lacking on reports of the toxicity of Synadenium umbellatum macerate. Resveratrol is a polyphenolic compound found in different plant species, mainly in grape species (Vitis) and their seeds. Vitis vinifera is a species of grape easily found in several regions, also containing a high concentrations of phenolic compounds, including resveratrol in its fruits, leaves and seeds. Therefore, this study was aimed to evaluate the myelotoxicity of macerate, extract and resveratrol and their antitumor activity in Balb/c mice with Ehrlich tumor. The hematological evaluation was obtained by flow cytometry and the tumors were measured using a pachymeter and the tumor masses by means of weighing. No statistically significant difference was observed between results from the control group and the treatment groups. It was concluded that macerate, crude extract and resveratrol did not demonstrate a myelotoxic effect and did not cause a decrease in tumor mass.

Keywords


Antineoplastics, Drug Toxicity, Phytotherapy.

References





DOI: https://doi.org/10.18311/jnr%2F2019%2F23383