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Rai, Balwant
- Bone Mineral Density (BMD), Bone Mineral Content (BMC), and MMP-8 and MMP-9 Levels in Human Mandibular and Alveolar Bone: A Study in Simulated Microgravity
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Authors
Affiliations
1 JBR Institute of Health Education and Research and Technology Society, India Assoc. Prof. (Programme Director Space Dentistry ), KSU, US
1 JBR Institute of Health Education and Research and Technology Society, India Assoc. Prof. (Programme Director Space Dentistry ), KSU, US
Source
Journal of Dento-Medical Science and Research, Vol 1, No 1 (2013), Pagination: 6-9Abstract
Exposure of astronauts and cosmonauts to microgravity conditions has been associated with several physiological changes including but not limited to an osteoporosis-like loss of bone mass. It has been reported that head-down tilt bed-rest studies mimic many of the observations seen in flights. However, to date there has been no study on the effects of mandibular bone and alveolar bone density loss in both sexes in a simulated microgravity environment. The current study was designed to determine bone mineral density (BMD) and GCF MMP-8 and MMP-9 levels in normal healthy subjects of both sexes in simulated microgravity conditions based on -6° head-down-tilt (HDT) bed rest. The subjects in this investigation were 10 male and 10 female volunteers participating in a three-week, 6° HDT bed-rest exposure. The BMD and Bone Mineral Content (BMC) of each individual were measured by dual energy X-ray absorptiometry before and during simulated microgravity. GCF MMP-8 and MMP-8 levels were measured by enzyme-linked immunosorbent assays. BMD and BMC levels were, in both genders, significantly <I>decreased</I> in simulated microgravity (although insignificantly a higher loss was observed in females as compared to males). In comparison, the MMP-8 and MMP-9 levels were significantly increased in simulated microgravity as compared to those in normal conditions (again insignificantly higher in females compared to males). Further studies are required using a larger sample size including all factors affected in simulated microgravity and true zero gravity.Keywords
Simulated Microgravity Condition, Head-down-tilt, Bone Loss, MMP-8, MMP-9, Bone Mineral Density (BMD), Bone Mineral Content (BMC)
References
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- Relationship Between Skeleton Method and Dental Method in Age Estimation in Children: A New Regression Equation
Abstract Views :593 |
PDF Views:2
Authors
Balwant Rai
1,
Jasdeep Kaur
1
Affiliations
1 JBR Institute of Health Education and Research and Technology Society, IN
1 JBR Institute of Health Education and Research and Technology Society, IN
Source
Journal of Dento-Medical Science and Research, Vol 1, No 1 (2013), Pagination: 15-17Abstract
Age estimation in children is not only important in forensic science but also in forensic dentistry. The orthopantomographs and hand-wrist radiographs samples of 25 healthy children (13 boys: 12 girls) aged between 5-17 years were selected and analyzing the possible applications of the proportion of carpal area and open apices of teeth as a criterion of age estimation. The regression model, describing age as a linear function of gender (G), ratio between carpal bones area (B) and carpel area (C) and measurement of open apices, results the following equation. Age= 5.675+0.512 G +0.567 No-0.782s+5.617 B/C-0.213 Nos. The correlation coefficient between open apices, B/C and chronological age were highly significant. This regression equation can be used for age estimation for medico-legal as well as clinical dentistry.Keywords
Forensic Science, Open Apices, Regression Equation, Carpal Bones Area, Carpel AreaReferences
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