International Journal of Physiology

Ravi Prakash ¹, P. Sowmya ²

Affiliations
1 Veditha Mind Care Clinic, Bangalore, Karnataka, IN
2 Department of Physiology, Bowring and Lady Curzon Medical College and Research Institute, Bangalore, Karnataka, IN

Abstract

Introduction: High band pass filtering of evoked potentials have produced the results of decreased early High frequency oscillations (HFOs) in previous studies of migraine patients. However, in most of these studies, the study population has been heterogeneous. The only study till date which used homogenous drug naive group of patients has actually produced contradictory results to the previous studies showing. Aim: We aimed to clarify the status of HFO amplitudes and latencies in drug-naive newly diagnosed patients. Methods: In the present study, we evaluated the 20 newly diagnosed and drug naive migraine patients using electrophysiological assessments using Somatosensory evoked potentials (SSEPs) and compared their SSEP parameters with those of the healthy age and gender matched normal controls. Median nerve SSEP was obtained by standard protocols. High frequency oscillations were extracted from the broad-band evoked potentials by digitally filtering using high pass filtering at 450Hz-1KHz. Early HFOs were identified when occurred before the N20 peak. Results: No differences were observed in the broad-band SSEPs i.e., N20 amplitudes and latencies. The maximal peak to peak amplitudes in the drug naïve migraineurs in between the attacks for the early HFOs (occurring before the N20 peak) were significantly smaller than the normal controls (p=0.046). The number of negative peaks were also fewer in the migraineurs in a statistically nonsignificant way. Discussion: This is the first HFO study on a homogenous population of migraineurs which shows decreased early HFOs, thus implicating weaker thalamocortical activity and contradicting the results by Lai et al¹.

Keywords

SSEP, HFO, Drug Naïve Migraineurs, Thalamocortical Activity.

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P. Sowmya ¹, J. Govindaraj ²

Affiliations
1 Department of Physiology, Bowring and lady Curzon medical college and research Institute, Bangalore, Karnataka, IN
2 Department of Physiology, Vijayanagar Institute of Medical Sciences, Ballari, Karnataka, IN

Abstract

Introduction: It is defined as an “umbrella term covering a group of non-progressive, but often changing, motor impairment syndromes secondary to lesions or anomalies of the brain arising in the early stages of its development”¹ primarily leading to a disorder of movement and posture. Objective: To assess autonomic functions in cerebral palsy individuals and their siblings. Method: Twenty cerebral palsy and sibling volunteers with no neurological damage were recruited for the study. Heart rate variability was used to assess the autonomic function. HRV was recorded in supine position for 5 minutes under quiet, calm conditions. Time domain parameters and frequency domain parameters were analyzed. Results: There was no statistically significant difference in any of the HRV parameters. There was no significant difference in HRV parameters in children with CP and healthy children indicating a normal sympatho-vagal balance. Conclusion: The presence of normal sympatho vagal balance in CP predicts that patients with CP have the same predilection as the general population to abnormalities associated with sympatho-vagal balance.

Keywords

Cerebral Palsy, HRV, Sympathetic Activity, Parasympathetic Activity, Sympatho Vagal Balance.

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