A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Biswas, D A
- Electrophysiological Evaluation of the Peripheral Nerves of the Upper Extremities in Patients of Chronic Obstructive Pulmonary Disease
Authors
1 Assistant Professor, Department of Physiology, Mahatma Gandhi Medical College &Hospital Jaipur Rajasthan
2 Professor and Head, Department of Physiology, Jawaharlal Nehru Medical College, Sawangi (Meghe) Wardha, Maharashtra
Source
International Journal of Physiology, Vol 1, No 2 (2013), Pagination: 13-18Abstract
Introduction: Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death, is a major health problem. COPD has been implicated as one of the causes of peripheral neuropathy. The influence of COPD in the peripheral nervous system has been the subject of clinical investigation only in the recent years. This study aimed at evaluating the nerve conduction velocity (NCV) and amplitude of peripheral motor and sensory nerves of the median and ulnar nerves of the upper extremities in patients of COPD when compared to healthy normal subjects.
Material and Method: The subjects (COPD patients and healthy volunteers) were assessed for anthropometric measurements, the pulmonary function tests and SpO2 levels. They were subjected for the nerve conduction test, of the median and ulnar nerves of the upper extremities
Results: A significant decrease in the NCV and amplitude for the median and ulnar nerves (both the components) at p value < 0.001was found in the COPD patients when compared to the control group, irrespective of the causative factor for COPD.
Conclusion: The presence of peripheral neuropathy was confirmed in COPD patients when compared to healthy control group, as the NCV and amplitudes of peripheral nerves (median and ulnar) of the upper extremities were found to be decreased in COPD patients.
Keywords
Chronic Obstructive Pulmonary Disease, Peripheral Neuropathy, Nerve Conduction StudiesReferences
- Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of Chronic Obstructive Pulmonary Disease. NHLBI/WHO report, NIH, NHLBI publication Number2701 updated 2008. Available from htpp:// www.goldcopd.org/guidelineitem/asp.
- Agust´A G. N. Systemic Effects of Chronic Obstructive Pulmonary Disease. Proc Am Thorac Soc. 2005; 2:367–370. Available at internet address www.atsjournals.org
- Valli G, Barbieri S, Sergi P, Fayoumi Z and Berardinelli P. Evidence of motor neuron involvement in chronic respiratory insufficiency. Journal of Neurology, Neurosurgery, and Psychiatry. 1984; 47: 1117-1121.
- Ozge A, Atis S, Sevim S. Subclinical peripheral neuropathy with chronic obstructive pulmonary disease. Electromyogr Clin Neurophysiol. 2001; 41:185- 191.
- Gupta PP, Agrawal D. Chronic Obstructive Pulmonary Disease and Peripheral Neuropathy. Lung India. 2006; 23: 25-33.
- Stratelis G, Jakobsson P, Molstad S and Zetterstrom O. Early detection of COPD in primary care: screening by invitation of smokers aged 40 to 55 years. British Journal of General Practice.2004; 54: 201-206
- Behera D, Jindal SK. Respiratory symptoms in Indian women using domestic cooking fuels. Chest. 1991; 100: 385-88.
- Mishra UK, Kalita J. Clinical Neurophysiology, 2nd edn. New Delhi Elsevier, Reed Elsevier India Private Limited. 2004:12-218.
- Agrawal D, Vohra R, Gupta PP, Sood S. Subclinical peripheral neuropathy in stable middle-aged patients with chronic obstructive pulmonary disease. Singapore Med J. Oct 2007; 48(10):887-94
- Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The evidence report NIH Publication September 1998; (98): 4083.
- Pfeiffer G, Kunze K, Brüch M, Kutzner M,LadurnerG, MalinJP et al. Polyneuropathy associated with chronic hypoxaemia: prevalence in patients with Chronic Obstructive Pulmonary Disease. J Neurol. 1990; 237: 230-233.
- Alppenzer O, Parks RD, Macgee J. Peripheral Neuropathy in Chronic Disease Of The Respiratory Tract. Am Jour of Med.1968; 44:873- 890.
- McCombe PA and McLeod JG The peripheral neuropathy of vitamin B12 deficiency Journal of the Neurological Sciences. October 1984; 66(1):117-126.
- Narayan M, Ferranti R. Nerve Conduction Impairment In Patients With Respiratory Insufficiency And Severe Chronic Hypoxemia. Arch Phys Med Rehabil.1978; 59: 188-92.
- Kayacan O, Beder S, Deda G, Karnak D. Neurophysiological changes in COPD patients with chronic respiratory insufficiency. Acta Neurol Belg. 2001; 101: 160-165.
- Jann S, Gatti A, Crespi S, Rolo J, Beretta S. Peripheral neuropathy in chronic respiratory insufficiency. J Peripher Nerv Syst. 1998; 3: 69-74.
- Faden A, Mendoza E, Flynn F. Subclinical neuropathy associated with chronic obstructive pulmonary disease possible pathophysiologic role of smoking. Arch Neurol. 1981 Oct; 38(10):639-42.
- Gokhan A, Cakan A, Erbaycu A E, Dereli S, Özsöz A, Edipoðlu H. Electromyographic Evaluation Of Peripheral Nerves In Chronic Obstructive Pulmonary Disease. Turkish Respiratory Journal. Aug 2003; 4(2):51-56.
- MayerP, Dematteis M, PépinJL, WuyamB, VealeD, VilaA, et al. Peripheral Neuropathy In Sleep Apnea A Tissue Marker Of The Severity Of Nocturnal Desaturation. Am J Respir Crit Care Med. Jan 1999; 159(1): 213-219.
- Auditory and Neurological Correlation in Auditory and Peripheral Neuropathy in Type II Diabetes Mellitus
Authors
1 Senior Resident,Department of Physiology, Maulana Azad Medical College, New Delhi
2 Head of Department of Physiology, Jawaharlal Nehru Medical College, Sawangi, Wardha
3 Head of Department, Department of Physiology, Maulana Azad Medical College, New Delhi
Source
International Journal of Physiology, Vol 1, No 2 (2013), Pagination: 71-76Abstract
Background: Diabetes mellitus is metabolic disorder of multiple etiologies characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects of insulin secretion, insulin action or both. The study was conducted with an aim to evaluate the effect of type II Diabetes mellitus on auditory brainstem response and conduction velocity of median nerve(motor component) and sural nerve (sensory component) and to correlate between auditory neuropathy and peripheral neuropathy due to type II Diabetes mellitus. The present study was undertaken in the Neurophysiology Laboratory, Department of Physiology, Jawaharlal Nehru Medical College Sawangi(Meghe) Wardha. It was a cross sectional case control study and a total of 100 subjects were studied out of which 50 were diabetics and 50 were age and sex matched controls. Effective nerve stimulation was obtained by the stimulus duration of 50μs to 1000μs and 0-100mA. Supramaximal stimulation (10-30% more than the current)was given. Electrode impedence was kept below 5k. BAEPs were recorded with the help of a computerized evoked potential recording system by monoaural stimulation and all the parameters have been compared at 70dBnHL stimulus intensityThe duration of diabetes in the study group with mean+S.D. is 6.92+2.08 years. There was no statistical significant difference in mean age and gender between the control group andstudygroup We founded increase in latency of waveV and interpeak latency III-V. There was decreased conduction velocity in median nerve and sural nerve of upper limb and lower limbfor motor nerve and sensory nerve respectivelyKeywords
Diabetes Mellitus, Brainstem Auditory Evoked Potential, Nerve Conduction VelocityReferences
- World Health Organization1999. Definition, diagnosis and classification of Diabetes Mellitus and its complications. Report of a WHO consultation, PartI.1999:1-31
- Data from the 2011 National Diabetes Fact Sheet (released Jan. 26, 2011)
- Lt Gen S R Mehta, ColAS Kashyap et al. Diabetes Mellitus in India: The modern Scourge. MJAFI 2009;65(1);50-54
- Diabetes Atlas, third edition, International Diabetes Federation,2006. http:// www.eatlas.idf.org/index2983.html.
- Diabetes fact sheetN312, World Health Organization, November 2008. http:// www.who.int/mediacentre/factsheets/fs312/en.
- Roy Freeman. The Nervous system and Diabetes. Joslin’s diabetes Mellitus, 14th edition2005:951-968
- Fujikawa S, Starr A. Vestibular neuropathy accompanying auditory and peripheral neuropathies. Arch Otolaryngol. 2000;126: 1463-1456
- Misra UK, Kalita J. Clinical Neurophysiology. Reprinted 2008. Published by Elsevier
- Friedman SA, Schuman RH,WeissS. Hearing and Diabetic neuropathy. Arch Intern Med.1975;135:573-576
- Lisowska, Gra¿yna,Namys³owski, Grzegorz,Morawski, Krzysztof, Strojek, Krzysztof. Early Identification of Hearing Impairment in Patients With Type 1 Diabetes Mellitus. Otology & Neurotology.2001;22(3): 316-320
- Luciana L et al Arq Bras Endocrinol Metab2003;47(1):82-86
- Babin RW, Liu C, Aschenbrener C. Histopathology of neurosensory deafness in sarcoidosis. Ann Otol Rhinol Laryngol. 1984;93:389-393.
- Terata K, Coppey LJ, Davidson EP, Dunlap JA, Gutterman DD, Yorek MA Acetylcholine-induced arteriolar dilation is reduced in streptozotocininduced diabetic rats with motor nerve dysfunction” Br J Pharmacol. 1999 Oct; 128(3): 837-43.
- Malik RA, Tesfaye S, Thompson SD, Veves A, Sharma AK, Boulton AJ, Ward JD. Endoneurial localisation of microvascular damage in human diabetic neuropathy. Diabetologia. 1993;36(5):454-9.
- Malik RA, Veves A, Masson EA, Sharma AK, Ah- See AK, Schady W, Lye RH, Boulton AJ.Endoneurial capillary abnormalities in mild human diabetic neuropathy. J Neurol Neurosurg Psychiatry. 1992;55(7):557-61.
- Veves A, Donaghue VM, Sarnow MR, Giurini JM, Campbell DR, LoGerfo FW. The impact of reversal of hypoxia by revascularization on the peripheral nerve function of diabetic patients. Diabetologia. 1996 Mar;39(3):344-8.
- Kennedy JM, Zochodne DW. Impaired peripheral nerve regeneration in diabetes mellitus. J Peripher Nerv Syst. 2005 Jun;10(2):144-57. .
- Ferrer, J, Birrun, O, Lorenete, J. et al. Auditory function in young patients with type I diabetes mellitus.Diabetes Research and Clinical Practice.1991;11:17-22.
- Fujikawa and Starr A and others. Auditory Neuropathy. Brain.1996;119:741-753
- C. Suzuki, I. Ozaki, M. Tanosaki, T. Suda, M. Baba, and M. Matsunaga. Peripheral and central conduction abnormalities in diabetes mellitus. Neurology 2000;54:1932-1937
- Chi-Re Huang, Chen-Hsien Lu1, Hsueh-Wen Chan, Nan-Wen Tsa, Wen-Neng Chang. Brainstem Auditory Evoked Potentials Study in Patients with Diabetes Mellitus. Acta Neurol Taiwan.2010;19:33-40