Effect of Duration of Disease and Glycemic Control on Attention, Executive Function and Visual Reaction Time in Type 2 Diabetes Mellitus Patients of Bangalore
Background: Type 2 diabetes mellitus a common endocrine disorder is on constant rise in the world. Diabetes mellitus is associated with premature mortality and several complications such as neuropathy, nephropathy and cardiovascular diseases. It can lead to decrease in psychomotor speed, executive functions, verbal memory, processing speed, complex motor functioning, working memory, visual retention and attention. These consequences have been attributed to glycemic control and duration of disease.
Objective: 1) To correlate duration of disease with attention, executive function and visual reaction time in type 2 diabetes patients.
2) To correlate HbA1c with attention, executive function and visual reaction time in type 2 diabetes patients.
Materials and Method: 60 uncomplicated Type 2 diabetes mellitus patients of either sex, aged 40-60 years were recruited from Diabetic Clinic Victoria Hospital, Bangalore. Ethical clearance & informed consent taken. After detailed examination & history taking, 2ml of fasting blood sample were taken for estimation of HbA1c. The cognitive tests include Digit vigilance test for attention, Stroop test for executive functions and visual reaction time using Human Benchmark software. Correlation was found using Pearson correlation, p value<0.05 taken as statistically significant.
Results: The Attention and executive function scores and visual reaction time are positively correlated with both duration of disease and HbA1c. Significant correlation is found with attention and Visual Reaction time with p value<0.05.
Conclusion: With progressive increase in the duration of disease and HbA1c levels there is decline in Attention and executive function & increase in Visual reaction time.
- Biessels GJ, Van Der Berg E, Craen AJM, Gussekloo J, Westendrop RGJ. The impact of diabetes mellitus on cognitive decline in the oldest of the old: a prospective population- based study. Diabetologia (2006); 49:2015-23.
- Sidhu J, Mittu S, Sidhu H. Visual reaction time changes in the type 2 diabetics and non-diabetics. Arch.Appl.Sci.Res.2015; 7(7):59-61.
- Yaffe TC, Gerstein HC, Williamson JD, Lazar RM, Lovato L, Miller ME et al. Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other Cardiovascular risk factor. Diabetes Care feb 2009; 32(2):221-25.
- Ruis C, Beissels GJ, Kappelle LJ, Donk M, Gorter KJ, Rutten G. Cognition in the early stages of type 2 diabetes. Diabetes care 2009; 32:1261-65.
- Munshi MN. Cognitive dysfunction in older adults with diabetes: What a clinician needs to know. Diabetes Care 2017; 40:461-67.
- Gluck ME, Ziker C, Schwegler M, Thearle M, Votruba SB, Krakoff J. Impaired glucose regulation is association with poorer performance on the Stroop task. Physiol Behav 2013 October 2; 122.
- Rao SL, Subbakrishna DK, Gopukumar K. NIMHANS Neuropsychology Battery 2004.
- Murray, M.M., Foxe, J.J., Higgins, B.A., Javitt, D.C., Shroeder, C.E. (2001). Visuo-spatial neural response interactions in early cortical processing during a simple reaction time task: a high-density electrical mapping study. Neuropsychologia, 39, 828-844.
- Kodl CT, Seaquist ER. Cognitive Dysfunction and Diabetes Mellitus. Endocr Rev. 2008 Jun; 29(4):494-511.
- Lamport DJ, Lawton CL, Mansfield MW, Dye L. Impairments in glucose tolerance can have a negative impact on cognitive function: a systematic research review. Neurosci Biobehav Rev. 2009; 33:394–413.
- Shorr R, de Rekeneire N, Resnick NK, Yaffe K, Somes GW,Kanaya M. Glycemia and cognitive function in older adults using glucose-lowering drugs. J Nutr Health Aging 2006.Jul-Aug; 10(4):297-301.
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