Study of Cognitive Evoked Potentials in Type 2 Diabetes Mellitus
Background: The completesyndrome of diabetes mellitus,related metabolic aberrations anddiabetic complications is posing a major threat in the 21st century. Cognitive dysfunction is a well known complication of diabetes which continues to be investigated.
Aims and Objectives: To evaluate the cognitive functions using electrophysiological (P300 latencies) tests in diabetics and non diabetics in the age group of 40 - 59 years with same gender proportion, to analyze whether cognition is affected in diabetics when compared to non diabetics and to know the usefulness of electrophysiological (P300latencies) tests in detecting subtle cognitive changes.
Materials and Method: The study was conducted on 50 diabetics and 50 non diabetics aged between 40 and 59 years. Cognition was assessed using P300 potential.The evoked potential data analysis was done using Student unpaired T test to compare the mean of two groups.
Results: The absolute peak latencies of P3 component of endogenous cognitive evoked potentials was significantly prolonged among diabetics (334.8 + 20.8) as compared to controls (285.7 + 14.9). There was no statistically significant difference between groups when analyzed for N2 in Czand Fz.
Conclusion: This study identifies prevalence of cognitive dysfunction in diabetic patients when assessed using electrophysiological tests.Good cognitive function is critical to safely manage diabetesand draws attention to various challenges in their management. Clinicians should consider screening for cognitive function in diabetics using P300, as it is effective in detecting subtle changes much before their clinical manifestation.
- Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, et al. Harrison’s principles of internal medicine. 17th ed. McGraw-Hill; 2008. 2275 -2304.
- Zimmet P. Alberti K G & Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001; 414: 782 – 789.
- IDF Diabetes atlas, 5th edition. International Diabetes Federation 2012.
- The Diabetes Control and ComplicationsTrial Research Group: The effect of intensivetreatment of diabetes on the developmentand progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977– 986.
- Worral G, Moulton N, Briffett E. Effect of type II diabetes mellitus on cognitive function. J Fam Pract1993; 36: 639-643.
- Arvanitakis Z, Wilson RS, Bienias JL,Evans DA, Bennet DA. Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol 2004; 61: 661 – 666.
- Sommerfield AJ, Deary IJ, Frier BM. Acute hyperglycemia alters mood state and impairs cognitive performance in people with type 2 diabetes. Diabetes care. 2004; 27 (10): 2335-2340.
- Donchin E, Ritter W, Mccallum WC. Cognitive psychophysiology: The endogenous components of the ERP. InEvent-Related Brain Potentials of Event related Brain Potentials in Man. Academic Press, New York 1978; 349-411.
- Di Leo MA, Di Nardo W, Cercones S, Ciervo A, Lo Monaco M, Greco AV, et al. Cochlear dysfunction in IDDM patients with subclinical peripheral neuropathy. Diabetes Care 1997; 20 (11): 1800-1803.
- Biessels GJ, Koffeman A, Scheltens P. Diabetes and cognitive impairment, Clinical diagnosis and brain imaging in patients attending a memory clinic. J Neurol 2006; 253: 477-482.
- Hissa MN, Artur CJ, D’Almeida, Cremasco F, Bruin VMS. Event related potential in NIDDM patients without cognitive impairment and its relationship with previous hypoglycemic episodes. Neuroendocrinollet 2002; 23: 226-230.
- Pozzessere G, Valle E, Crignis S D, Cordischi VM, Fattapposta F, Rizzo PA et al. Abnormalities of cognitive function in insulin dependent diabetes mellitus revealed by P300 event related potential analysis compared with short latency evoked potentials and psychometric tests. Diabetes1991; 40(8): 952-958.
- Mooradian AD, Perryman K, Fitten J, Kavonian GD and Morley JE . Cortical function in elderly noninsulin dependent diabetes patients. Arch Intern Med 1988; 1489(11): 2369-2372.
- Tandon OMP, Verma A and Ram BK. Cognitive dysfunction in NIDDM: p3 event related evoked potential study. Indian J PhysiolPharmacol 1999; 43 (3): 383-388.
- Andreadou E, Mitrakou A, Constantindes VC, Triantafyllou N. Auditory P300 event related potentials in patients with type 2 diabetes mellitus. J Diab Res Clin Met 2012; 1-7.
- Picton, TW and Hillyard SA. Human auditory evoked potentials. II. Effects of attention. Electroencephalogr Clin Neurophysiol 1974; 36: 191-199.
- Ritter W, Ford JM, Gaillard AWK, Harter RM, Renault DMK, Rohrbaugh J Cognition and eventrelated potentials. I. The relation of negative potentials and cognitive processes. Ann N Y Acad Sci 1984; 425:24-38
- Polich, J. Attention, probability, and task demands as determinants of P300 latency from auditory stimuli. Electroencephalogr Clin Neurophysiol 1986; 63: 251-259.
- Korff VM, Gruman J, Schaefer J, Curry SJ, Wagner EH: Collaborative management of chronic illness. Ann Intern Med 1997; 127: 1097 –1102.
- Gregg EW, Yaffe K, Cauley JA, Rolka DB, Blackwell TL, Narayan KMV et al. Is diabetes associated with cognitive impairment and cognitive decline among older women? Arch Intern Med 2000; 160: 174 – 180.
- Connis RT, Taylor TR, Gordon MJ, Mecklenburg RS, Li ljenguist JE, Stephens JW, Baker MS. Changes in cognitive and social functioning ofdiabetic patients following initiation of insulin infusion therapy. Exp Aging Res 1989; 15: 51-60.
Abstract Views: 7
PDF Views: 0