Study of Parasympathetic Activity in Newly Diagnosed Patients of Moderate Depression Using High Frequency of HRV
Introduction: - Heart Rate Variability (HRV) is a noninvasive technique to measure parasympathetic activities of heart. In this study, we measured the Parasympathetic activity in newly diagnosed patients of moderate depression by High Frequency (HF) parameter of HRV. Depression is the leading cause of mental disability and by the year 2020, depression is projected to reach 2nd place of the ranking of disease disability-adjusted life year (DALY).
Objective: Parasympathetic activity in newly diagnosed patients of moderate depression.
Method:- this study was planned on 40 newly diagnosed male patients of moderate depression according to ICD-10 (the international classification of diseases-10) taken from department of Psychiatry PGIMS Rohtak and 40 healthy males subjects of same age group. High Frequency (HF) parameter of HRV was recorded by using RMS polyrite machine.
Result: - The HF (ms2) component in frequency domain of HRV in patients of moderate depression in group II (166.55±41.48) compared to normal subject in group I (179.48±41.68) which reduced but not significantly. The HF expressed in normalized unit (HFnu) and group II (35.30±12.58) were compared to Group I (38.74±1276) and which reduced but not significantly. And HF expressed in power percent (HFpp) and values of group II (18.83±5.04) were compared to the Group I (20.58±5.02), the reduction was not significant.
Conclusion:-We found that Parasympathetic activity was not reduced significantly in patients of moderate depression. So the parasympathetic activity is not a problem to cause cardiac disease in patients of moderate depression.
- Wittchen HU, Pittrow D. Prevalence, recognition and management of depression in primary care in Germany: the depression 2000 study. Hum Psychopharmacol 2002;17:1–11.
- Michaud CM, Murray CJ, Bloom BR. Burden of disease: implications for research. JAMA 2001;285:535-9.
- Pothen M, Kuruvilla A, Philip K, Joseph A, Jacob KS. Common mental disorders among primary care attenders in Vellore, south India: nature, prevalence and risk factors. Int J Soc Psych 2003;49:119-25.
- Nambi SK, Prasad J, Singh D, Abraham V, Kuruvilla A. Explanatory models and common mental disorders among patients with unexplained somatic symptoms attending a primary care facility in Tamil Nadu. Natl Med J India 2002;15:331-5.
- Mirza I, Jenkins R. Risk factors, prevalence, and treatment of anxiety and depressive disorders in Pakistan: a systematic review. BMJ 2004;328:794.
- Stordal E, Mykletun A, Dahl AA. The association between age and depression in the general population: a multivariate examination. Acta Psychiatrica Scandinavica 2003;107:132-41.
- Lerer B, Gillan D, Lietenberg P, Gorfine M, Gelfin Y. Inter relationship of age, depression and central serotonergic function: evidence from fenfluramine challenge studies. Int Psychogeriatry 1996;8:83-102.
- Mirowsky J, Ross CE. Age and depression. J Health Soc Behav 1992;33:187-205.
- Blazer DG, Kessler RC, McGonagle KA, Swartz MS. The prevalence and distribution of major depression in a national community sample: the national co-morbidity survey. Am J Psychiatry 1994;151:979-86.
- Bebbington PE, Dunn G, Jenkins R. The influence of age and sex on the prevalence of depressive conditions: report from the national survey of psychiatric morbidity. Psychol Med 1998;28:9-19.
- Salokangas RK, Poutanen O. Risk factors for depression in primary care: findings of the TADEP project. J Affect Disord 1998;48:171-80.
- Poongothai S, Pradeepa R, Ganesan A, Mohan V. Prevalence of Depression in a large urban south indian population: the Chennai urban rural epidemiology study. Plos One 2009;4(9):e7185.
- ICD-10 Classification of mental and behavioural disorder. Clinical descriptions and diagnostic guidelines. Indian ed. Delhi: A.I.T.B.S. Publishers; 2007. p. 110-11.
- Katira R, Narain VS, Puri VK. Heart rate variability. JAPI 1997;45:49-51.
- Juha PN P, Tarvainen PO, Ranta PA, Karjalainen. Software for advanced HRV analysis. Comptr Methds Progrms Biomed 2004;76:73-81.
- Brenner KM, Thomas S, Shepherd RJ. Autonomic regulation of the circulation during exercise and heat exposure: inferences from heart rate variability. Sports Med 1998;26:85-99.
- Malik M, Bigger JT, Camm AJ, Kleiger RE, Mallini A, Moss AJ et al. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability standards of measurement, physiological interpretation, and clinical use. Euro Heart J 1996; 17:354-81.
- Julian FT, Smith M, Rossy LA, John JS, Friedman BH. Heart period variability and depressive symptoms: gender differences. Biol Psych 1998;44:304-6.
- Rottenberg J. Cardiac vagal control in depression: a critical analysis. Biological Psychol 2007;74:200-11.
Abstract Views: 134
PDF Views: 0