A Study of Nerve Conduction Test & Other Hematological Parameters in Diabetics
Background: Nerve conduction studies (NCS) are most sensitive, reliable and non-invasive investigation to detect diabetic neuropathy. Sensory nerves are more affected as compared to motor nerves in diabetic neuropathy. Understanding the Nerve conduction studies is useful for early detection polyneuropathy and prevention of its dreaded complications.
Materials and Method: The present study was conducted among 30 subjects of type 2 Diabetic and 30 non diabetics subjects. Haematological parameters such as HbA1c, platelet count, prothrombin time, APTT, triglycerides, LDL and HDL levels were estimated. Motor nerve conduction velocity median , ulnar, common peroneal and posterior tibial nerve and sensory nerve conduction velocity median , ulnar and sural nerve were recorded.
Result: Mean age of diabetic patients was 51±.4.8 year. Most of the subjects (86.7%) were male. Sensory nerve conduction of sural nerve was signiicantly reduced in diabetic patients as compared to non diabetic patients. SNCV of sural nerve showed deterioration with the duration of diabetes, poor glycemic control and patients with altered lipid profile.
Conclusion: Nerve conduction velocity testing of sural nerve is useful for early detection of diabetic neuropathy and reduce the burden of complication and to improve the quality of life in diabetics.
- Agarwal S, Lukhmana S, Kahlon N, Malik P, Nandini H. Nerve conduction study in neurologically asymptomatic diabetic patients and correlation with glycosylated hemoglobin and duration of diabetes. National Journal of Physiology, Pharmacy and Pharmacology. 2018;8(11):1533-8.
- Pradeepa R, Rema M, Vignesh J, Deepa M, Deepa R, Mohan V. Prevalence and risk factors for diabetic neuropathy in an urban south Indian population: the Chennai Urban Rural Epidemiology Study (CURES‐55). Diabetic Medicine. 2008 Apr;25(4):407-12.
- Franklin GM, Shetterly SM, Cohen JA, Baxter J, Hamman RF. Risk factors for distal symmetric neuropathy in NIDDM: the San Luis Valley Diabetes Study. Diabetes Care. 1994 Oct 1;17(10):1172-7.
- Claus D, Mustafa C, Vogel W, Herz M, Neundörfer B. Assessment of diabetic neuropathy: Definition of normal and discrimination of abnormal nerve function. Muscle & Nerve: Official Journal of the American Association of Electrodiagnostic Medicine. 1993 Jul;16(7):757-68.
- Lamontagne A, Buchthal F. Electrophysiological studies in diabetic neuropathy. Journal of Neurology, Neurosurgery & Psychiatry. 1970 Aug 1;33(4):442-52.
- Hendriksen PH, Oey PL, Wieneke GH, Bravenboer B, Van Huffelen AC. Subclinical diabetic polyneuropathy: early detection of involvement of different nerve fibre types. Journal of Neurology, Neurosurgery & Psychiatry. 1993 May 1;56(5):509-14.
- Kannan MA, Sarva S, Kandadai RM, Paturi VR, Jabeen SA, Borgohain R. Prevalence of neuropathy in patients with impaired glucose tolerance using various electrophysiological tests. Neurology India. 2014 Nov 1;62(6):656.
- Herman WH, Aubert RE, Engelgau MM, Thompson TJ, Ali MA, Sous ES, Hegazy M, Badran A, Kenny SJ, Gunter EW, Malarcher AM. Diabetes mellitus in Egypt: glycaemic control and microvascular and neuropathic complications. Diabetic Medicine. 1998 Dec;15(12):1045-51.
- Chatzikosma G, Pafili K, Demetriou M, Vadikolias K, Maltezos E, Papanas N. Evaluation of sural nerve automated nerve conduction study in the diagnosis of peripheral neuropathy in patients with type 2 diabetes mellitus. Archives of medical science: AMS. 2016 Apr 1;12(2):390.
- Squintani G, Zoppini G, Donato F, Pineschi E, Donini D, Stoico V, Moretto G, Bonora E, Morini A. Antidromic sensory nerve conduction study of the digital branches of the medial plantar nerve: a novel method to detect early diabetic sensory axonal polyneuropathy. Muscle & nerve. 2014 Aug;50(2):193-9.
- Gul S, Dar MA, Ali A, Ashraf A, Qadri S. Prevalence of peripheral neuropathy and pattern of involvement on nerve conduction study in patients of type 2 diabetes mellitus with clinical symptoms of peripheral neuropathy in Kashmiri population: a hospital-based study. Imperial J Interdisciplinary Res. 2017;3(2).
- American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018 1;41(Supplement 1):S13-27.
- Franssen H. Nerve conduction studies in polyneuropathy: practical physiology and patterns of abnormality. Acta neurologica belgica. 2006 Jun;106(2):73-81.
- Lee WJ, Jang S, Lee SH, Lee HS. Correlation between the severity of diabetic peripheral polyneuropathy and glycosylated hemoglobin levels: a quantitative study. Annals of rehabilitation medicine. 2016 Apr;40(2):263.
- Oguejiofor OC, Odenigbo CU, Oguejiofor CB. Evaluation of the effect of duration of diabetes mellitus on peripheral neuropathy using the United Kingdom screening test scoring system, biothesiometry and aesthesiometry. Nigerian journal of clinical practice. 2010;13(3).
- Harati Y. Diabetic neuropathies: unanswered questions. Neurologic clinics. 2007 Feb 1;25(1):303-17.
- Fazan VP, de Vasconcelos CA, Valenca MM, Nessler R, Moore KC. Diabetic Peripheral Neuropathies: A Morphometric Overview. International Journal of Morphology. 2010 Mar 1;28(1).
Abstract Views: 132
PDF Views: 0