Impact of Obesity on Castelli’s Risk Index I and II, in Young Adult Females
Background: Obesity is one of today’s most blatantly visible, yet most neglected, public health problems. In 2016, 39% of adults worldwide were overweight. Fueled by economic growth, urbanization, an increasingly sedentary lifestyle, and a nutritional transition to processed foods and high calorie diets over the last 30 years, many countries have witnessed the prevalence of obesity in its citizens double, and even quadruple. Obesity especially visceral obesity causes insulin resistance and is associated with dyslipidemia, impaired glucose metabolism, and hypertension all of which exacerbate atherosclerosis, and are risk factors for developing cardiovascular diseases (CVD). The primary dyslipidemia related to obesity is characterized by increased total cholesterol (TC), decreased high density lipoprotein (HDL) levels and abnormal low density lipoprotein (LDL) composition. Lipoprotein ratios are becoming increasingly popular as a way to predict atherosclerosis and CVD.
Aims and Objectives: The present study was undertaken to assess the impact of overweight/obesity on lipid profile parameters and lipoprotein ratios- Castelli’s Risk Index I and II, in young adult females.
Materials and Method: The present study was conducted in KIMS, Hubli, the study and its conduct was cleared by the Ethical committee. Sixty apparently healthy young females were selected for the study. Health status and other personal data were obtained via comprehensive questionnaire. The subjects were divided into two groups based on BMI; Healthy (BMI 18.5-24.99) and Overweight (BMI > 25). Lipid profile was evaluated and lipoprotein ratios calculated. Comparison between the two groups was done using students’ t-test.
Results: Values for Castelli’s Risk Index I & II were found to be significantly higher in the overweight group compared to the control group.
Conclusion: Obesity leads to an unfavorable lipid pattern and raises values of both Castelli’s Risk Index I & II.
- Global Health Observatory (GHO) data. https:// www.who.int/gho/ncd/en/. Accessed on 07/09/2019.
- Pi-Sunyer X. The medical risks of obesity. Postgrad Med 2009; 121(6):21–33.
- AK Singh, S K Singh, N Singh, N Agrawal, K Gopal. Obesity and dyslipidemia. Int J Biol Med Res 2011; 2(3): 824-828.
- Boudewijn Klop, Jan Willem F. Elte, and Manuel Castro Cabezas. Dyslipidemia in Obesity: Mechanisms and Potential Targets. Nutrients. 2013; 5(4): 1218–1240.
- Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J, Lisheng L, INTERHEART Study Investigators. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 2004; 364(9438):937-52.
- Miller M. Dyslipidemia and cardiovascular risk: the importance of early prevention. QJM 2009; 102(9):657–667.
- Wolf D, Ley K. Immunity and Inflammation in Atherosclerosis. Circ Res 2019; 124(2):315-327.
- Bhardwaj S, Bhattacharjee J, Bhatnagar MK, Tyagi S. Atherogenic index of plasma, Castelli risk index and atherogenic coefficient- new parameters in assessing cardiovascular risk. Int J Pharm Bio Sci 2013; 3:359–64.
- Nair D, Carrigan TP, Curtin RJ, Popovic ZB, Kuzmiak S, Schoenhagen P, Flamm SD, Desai MY. Association of total cholesterol/ high-density lipoprotein cholesterol ratio with proximal coronary atherosclerosis detected by multislice computed tomography. Prev Cardiol 2009; 12(1):19-26.
- Maksvytis A, Stakisaitis D. Impact of obesity on lipid profiles in middle-aged women. Medicina (Kaunas). 2004;40(6):553-7.
- Gilles Plourde. Impact of obesity on glucose and lipid profiles in adolescents at different age groups in relation to adulthood. BMC Family Practice 2002; 3:18.
- K Suneetha. Study of Lipid Profile in Obese and Non-obese Students in Acharya Nagarjuna University. International Journal of Pharmaceutical and Clinical Research 2018; 10(2):40-42.
- Bassi R, Sharma S, Kaur M, Sharma A. A study of changes in lipid profile in obese and non-obese females with acne vulgaris. Natl J Physiol Pharm Pharmacol 2014; 4:125-127.
- Myat Su Bo, Whye Lian Cheah, Soe Lwin, Tin Moe Nwe, Than Than Win, and Myint Aung, “Understanding the Relationship between Atherogenic Index of Plasma and Cardiovascular Disease Risk Factors among Staff of an University in Malaysia,” Journal of Nutrition and Metabolism 2018;Article ID 7027624.
- Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Circulation. 2002; 106(25):3143-421.
- Superko HR, King S. Lipid management to reduce cardiovascular risk: a new strategy is required. Circulation 2008; 117(4):560-8.
- Olamoyegun MA, Oluyombo R, Asaolu SO. Evaluation of dyslipidemia, lipid ratios, and atherogenic index as cardiovascular risk factors among semi-urban dwellers in Nigeria. Ann Afr Med 2016; 15(4):194–199.
- I. Stensvold, A. Tverdal, P. Urdal et al., “Non-fasting serum triglyceride concentration and mortality from coronary heart disease and any cause in middle aged Norwegian women,” British Medical Journal 1993;307(6915):1318–1322.
- Du T, Yuan G, Zhang M, Zhou X, Sun X, Yu X. Clinical usefulness of lipid ratios, visceral adiposity indicators, and the triglycerides and glucose index as risk markers of insulin resistance. Cardiovasc Diabetol 2014; 13:146.
- Young SG, Parthasarathy S. Why are low-density lipoproteins atherogenic? West J Med 1994; 160(2):153–164.
- Feingold KR, Grunfeld C. Introduction to Lipids and Lipoproteins. [Updated 2018 Feb 2]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK305896/. Accessed on 07/09/2018.
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