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Ogugua, Victor N.
- Nutritional and Toxicological Potentials of Mucuna pruriens Seed
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Authors
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1 Department of Biochemistry, University of Nigeria, Nsukka, NG
1 Department of Biochemistry, University of Nigeria, Nsukka, NG
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 4 (2011), Pagination: 168-170Abstract
Since animals and animal products are very expensive sources of nutrients especially in developing countries, it is very important to exploit other sources of acquiring nutrients that will be less expensive. This work was therefore aimed at evaluating the nutritional and toxicological potentials of Mucuna pruriens seed in view of proposing a less expensive source of nutrient in developing countries. The phytochemical analysis was carried out using the method of Harbourne et al. (1973). The proximate analysis, elementary analysis and determination of toxicants were determined using standard biochemical methods. Results of the phytochemical analysis showed the presence of alkaloids, proteins, carbohydrates, saponins, tannins in high concentration; flavonoids in moderate concentration while cyanogenic glycosides and steroidal aglycones were absent. Proximate analysis revealed high percentage of crude protein (30.1±0.25%) while ash (8.2±0.2%), moisture (7.67±0.34%) and fiber (3.2±0.01%) were in moderate percentages. The mineral composition indicated the presence of iron (33.75±0.18μg/100g), potassium (700.02±48.7μg/100g) and phosphate (622±7.29μg/100g). The results also showed the presence of some toxicants, oxalate (11887.5±517.1μg/g) in high concentration while phytate (61.3±0.45μg/g), hemagglutinin (14.67±0.69μg/g) and cyanogenic glycosides (0.013±0.59μg/g) were present in low concentrations. We therefore conclude from our results that well processed Mucuna pruriens seed would not only be a less expensive source of nutrient in developing countries but may also provide medical benefits.Keywords
Toxicology, Mucuna pruriens, Nutrients, Toxicology, Phytochemistry.
References
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- Toxicological Studies of Aqueous Leaf Extract of Mucuna pruriens on Albino Rats
Abstract Views :245 |
PDF Views:2
Authors
Affiliations
1 Department of Biochemistry, University of Nigeria, Nsukka, IN
1 Department of Biochemistry, University of Nigeria, Nsukka, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 5 (2011), Pagination: 253-255Abstract
The leaves of Mucuna pruriens have been used traditionally for the treatment of various ailments but little information has been documented about its toxicological studies of the aqueous leaf extract of Mucuna pruriens on albino rats to ascertain its hepatotoxic effect when used in traditionally medicine. Preliminary phytochemical analysis was carried out by the method of Harboune (1973). The ALT and AST concentrations were measured using Human test kits (Germany). Total protein and bilirubin were measured using standard biochemical methods as described in Amadi et al. 2004. The phytochemical analysis indicated the presence of flavonoids, tannins, terpenoids, alkaloids, saponins and trace amounts of cyanogenic glycosides. The leaf extract of graded doses of 400 and 800mg/kg body weight given orally to the rats caused no significant increase or decrease (p>0.05) in the serum ALT, AST, total protein and bilirubin concentrations when compared to the controls. From the results of our study, we therefore conclude that the aqueous leaf extract of Mucuna pruriens had no hepatotoxic effect at the investigated doses and thus can be used in traditional medicine. However, further research needs to be carried out on higher doses and duration.Keywords
Toxicology, Mucuna pruriens, Hepatotoxic, Phytochemistry.References
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