Refine your search
Collections
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Subramaniyan, Vetriselvan
- Antioxidant, Antidiabetic, and Antihyperlipidemic Activities of Dolichandrone atrovirens in Albino Wistar rats
Abstract Views :307 |
PDF Views:0
Authors
Saminathan Kayarohanam
1,
Vetriselvan Subramaniyan
2,
Ashok Kumar Janakiraman
3,
S. J. Madhan Kumar
3
Affiliations
1 Geomatika University College Kuala Lumpur, 54200, MY
2 Department of Pharmacology, MAHSA University, 42610, MY
3 UCSI University, Kuala Lumpur, 56000, MY
1 Geomatika University College Kuala Lumpur, 54200, MY
2 Department of Pharmacology, MAHSA University, 42610, MY
3 UCSI University, Kuala Lumpur, 56000, MY
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3511-3516Abstract
Aim: To investigate the antioxidant, antidiabetic, and antihyperlipidemic activities of Dolichandrone atrovirens in albino wistar rats. Methods and Material: Bark and leaf part of Dolichandrone atrovirens were extracted with water and methanol. Swiss albino wistar rats were used to evaluate the in vivo effects of streptozotocin induced body weight loss, oxidative stress, hyperglycemia and hyperlipidemia. Statistical analysis : Data were analysed by One - way ANOVA, followed by Turkey –Kramer Multiple Comparison Test. Results: Dolichandrone atrovirens extract treated animals demonstrated significant increase in body weight, decreased blood glucose levels, glycosylated haemoglobin and changes in other biochemical parameters levels when compared to diabetic control rats.Keywords
Dolichandrone atrovirens, Streptozotocin, in Vivo Activity, Antidiabetic.
References
- Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004, 27:1047-53.
- King H1, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care. 1998, 21:1414-31.
- Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Carapetis J et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. The lancet. 2012, 380:2095–2128.
- Jared Diamond. Medicine: Diabetes in India. Nature. 2011; 469:478–479.
- Kameswara Rao B, Kesavulu M,Giri M, and Appa Rao CH. Antidiabetic and hypolipidaemic effects of momordicacymbalaria Hook, fruit powder in alloxan diabetic rats. J. Ethnopharmacol. 1999; 67: 103-109.
- Dunlop M. Aldose reductase and the role of the polyol pathway in diabetic nephropathy. Kidney Int Suppl. 2000; 77: S3-12.
- Young RJ, Ewing DJ, Clarke BF. A controlled trial of sorbinil, an aldose reductase inhibitor, in chronic painful diabetic neuropathy. Diabetes. 1983; 32:938-42.
- Engerman RL. Pathogenesis of diabetic retinopathy. Diabetes. 1989 Oct; 38:1203-6.
- Mohammad-Ali Javadi, MD and Siamak Zarei-Ghanavati, MD. Cataracts in Diabetic Patients: A Review Article J Ophthalmic Vis Res. 2008; 3(1): 52–65.
- Howard BV. Lipoprotein metabolism in diabetes mellitus. J Lipid Res 1978; 28: 613-628.
- V. Suba, T. Murugesan, G. Arunachalam, S. C. Mandal and B. P. In vitro antidiabetic activity of Dolichandrone atrovirens – an Indian medicinal plant. Inter. J. of Pharmacotherapy 2014, 107-113.
- Kavimani S, Saminathan Kayaroanam, Senthil Kumar R. Evaluation of the antidiabetic effect of Momordica cymbalaria fruit in alloxan-diabetic rats. Fitoterapia. 2003, 74:7–13.
- Rahman Q, Zaman K. Medicinal plants with hypoglycaemic activity. J Ethnopharmacol.1989; 26:1–55.
- Handa R, Mundkinajeddu D, Mangal AK. Indian pharmacopeia. Delhi: Government of India, Ministry of Health and Family Welfare, Controller of Publications; 1996.
- Mukherjee P, Maiti K, Mukherjee K, Houghton PJ. Leads from Indian medicinal plants with hypoglycemic potentials. J Ethnopharmacol. 2006; 106: 1-28.
- Saminathan Kayarohanam and S Kavimani. Current Trends of Plants Having Antidiabetic Activity: A Review. Bioanalysis and Biomedicine. 2015; 7(2): 055-065.
- World health organization. The WHO expert committee on diabetes mellitussecond report. Geneva: World Health Organization Technical Report Series 1980; 646:1-80.
- Ahmed, R.G. The physiological and biochemical effects of diabetes on the balance between oxidative stress and antioxidant defense system. Med. J. Islamic World Acad. Sci. 2005; 15: 31-42.
- Deore AB, Sapakal VD, Naikwarde NS. Role of oxidative stress in pathogenesis of diabetes and its complications. Pharmacologyonline.2011; 2: 603-621.
- Kavimani S, Saminathan Kayarohanam, Senthil Kumar R. Antioxidant and free radical scavenging activities of Dolichandrone atrovirens using various in vitro assay models. International Journal of Phytopharmacology. 5(4), 2014, 293-300.
- Aneta Wojdyło, Jan Oszmian´ski, Renata Czemerys. Antioxidant activity and phenolic compounds in 32 selected herbs. Food Chemistry 2007; 105:940–949.
- Searle AJ, Wilson RL. Glutathione peroxidase: Effect of superoxide, hydroxyl and bromine free radicals on enzyme activity. Int J Radiat Biol Relat Stud Phys Chem Med. 1980; 37:213.
- Kaleem M, Asif M, Ahmed QU, Bano B. Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Med J. 2006; 47:670–5.
- Freeman BA, Crapo JD. Biology of disease: Free radicals and tissue injury. Lab Invest. 1982; 47:412.
- Hodgson EK, Fridovich I. The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: Inactivation of the enzyme. Biochemistry. 1975; 24:5294.
- Dangi KS, Mishra SN. Antioxidative and a cell regeneration effect of Capparis aphylla stem extract in streptozotocin induced diabetic rat. Biol Med. 2011; 3:82–91.
- Ji X, Zhang P, Armstrong RN, Gilliland GL. The three-dimensional structure of a glutathione S-transferase from the mu gene class. Structural analysis of the binary complex of isoenzyme 3-3 and glutathione at 2.2-A resolution. Biochemistry. 1992; 1:10169–84.
- Semiz A, Sen A. Antioxidant and chemoprotective properties of Momordica charantia L. (bitter melon) fruit extract. Afr J Biotechnol. 2007; 6:273–7.
- Andallu B, Varadacharyulu NC. Antioxidant role of mulberry leaves in streptozotocin-diabetic rats. Clin Chim Acta. 2003; 338:3.
- Kumar P, Kale RK, Mukherjee S, Prakash K, McLean P, Baquer NZ. Antidiabetic effects of Trigonella foenum-graecum seed powder in a rat model. Toxicol Environ Chem. 2011; 93:2085–97.
- Takeshita F, Kodama M, Yamamoto H, Ikarashi Y, Ueda S, Teratani T, Yamamoto Y, Tamatani T, Kanegasaki S, Ochiya T, Quinn G. Streptozotocin-induced partial beta cell depletion in nude mice without hyperglycemia induces pancreatic morphogenesis in transplanted embryonic stem cells. Diabetologia. 2006; 49:2948–58.
- Sandler S, Swenne I. Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro. Diabetologia. 1983; 25:444–447.
- Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res. 2001; 50:537–546.
- Ikebukuro K, Adachi Y, Yamada Y, Fujimoto S, Seino Y, Oyaizu H. Treatment of Streptozotocin-induced diabetes mellitus by transplantation of islet cells Plus bone Marrow cells via portal vein in rats. Transplantation. 2002; 73:512-8.
- Rabbani SI, Devi K, Khanam S. Inhibitory effect of glimepiride on the nicotinamide-streptozotocin induced nuclear damages and sperm abnormalities in diabetic Wistar rats. Indian J Exp Biol 2009; 47: 804-810
- Swanston-Flat SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes: studies in normal and streptozotocin diabetic mice. Diabetologia. 1990; 33:462-464.
- Wu KK, Huan Y. Diabetic atherosclerosis mouse models. Atherosclerosis .2007; 191:241–249.
- Haffner, SM, Lehto S, Ronnemaa, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. New England Journal of Medicine. 1998; 339:229–234.
- Goldstein JL, Schrott HG, Hazzard WR, Bierman EL, Motulsky AG. Hyperlipidaemia in coronary heart disease II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidaemia. J Clin Invest. 1973; 52:1544–1568.
- Kavimani S, Saminathan Kayarohanam, Senthil Kumar R. In vitro antidiabetic activity of Dolichandrone atrovirens – an Indian medicinal plant. Inter. J. of Pharmacotherapy / 4(3), 2014, 107-113.
- Babu, PV, Sabitha, KE, Shyamaladevi, CS. Green tea impedes dyslipidaemia, lipid peroxidation, protein glycation and ameliorates Ca2+-ATPase and Na+/K+-ATPase activity in the heart of streptozotocin-diabetic rats. Chemico-Biological Interactions. 2006;162: 157–164.
- Fadzelly A.B, Asmah R, Fauziah, O. Effects of Strobilanthes crispus tea aqueous extracts on glucose and lipid profile in normal and streptozotocin-inducedhyperglycaemic rats. Plant Foods for Human Nutrition. 2006; 61: 7–12.
- Ravi K, Rajasekaran S, Subramanian S. Antihyperlipidaemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats. Food and Chemical Toxicology.2005; 43: 1433–1439.
- Mythili, M.D, Vyas R, Akila G, Gunasekaran S. Effect of streptozotocin on the ultrastructure of rat pancreatic islets. Microscopy Research and Technique. 2004; 63: 274–281.
- Rahimi R, Nikfar S, Larijani B, Abdollahi M. A review on the role of antioxidants in the management of diabetes and its complications. Biomed Pharmacother. 2005; 59:365–373.
- Aslan M, Orhan N, Orhan DD, Ergun F. Hypoglycaemic activity and antioxidant potential of some medicinal plants traditionally used in Turkey for diabetes. J Ethnopharmacol. 2010; 128(2):384–389.
- Saminathan Kayarohanam and S.Kavimani. Quantitative phytochemical and GC-MS analysis of leaf and bark extract of Dolichandrone Atrovirens. International Research Journal of Pharmacy 2015; 6 (3).
- Sroka Z, Cisowski W. Hydrogen peroxide scavenging, antioxidant and anti-radical activity of some phenolic acids. Food Chem Toxicol. 2003; 41: 753–758.