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Gupta, Vani
- Association of Circulating Resistin with Metabolic Risk Factors in Indian Females Having Metabolic Syndrome
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Authors
Affiliations
1 Department of Physiology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, IN
2 Department of Obstetrics and Gynecology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, IN
3 In Vitro Toxicology Laboratory, Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, IN
1 Department of Physiology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, IN
2 Department of Obstetrics and Gynecology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, IN
3 In Vitro Toxicology Laboratory, Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 18, No 2 (2011), Pagination: 168-172Abstract
Role of resistin in insulin sensitivity and metabolic syndrome (MetS) is controversial till date. Increased serum resistin levels are associated with MetS and insulin resistance. The aim of this study was to investigate the relationship between serum resistin levels with markers of the MetS in females. In a cross-sectional study, a total of 170 healthy female subjects were selected for the study. Out of which 71 (age 31.59 ± 4.88 years) were with MetS and 99 (age 31.75 ± 6.34 years) were without MetS. Different parameters of MetS and serum resistin level were measured according to the standard protocols as given in NCEP ATP III 2001 guideline. Serum resistin levels were significantly higher in subjects with MetS when compared with subjects without MetS [13.54 ± 4.14 ng/ml (n = 71) vs. 7.42 ± 2.31 ng/ml (n = 99); P ≤ 0.001]. Resistin levels were positively associated with waist circumference, systolic and diastolic blood pressure, plasma glucose, waist/hip ratio, serum triglycerides, serum cholesterol, serum VLDL, plasma insulin, and insulin resistance, while it was negatively associated with highdensity lipoprotein. This study demonstrates a positive correlation between resistin and factors of MetS except high-density lipoprotein which was found to be negatively correlated in Indian female subjects.Keywords
Insulin resistance, metabolic syndrome, resistin
- Association Between Circulating Inflammatory and Anti-Inflammatory Proteins and Risk of Development of Type II Diabetes Mellitusin Indian Obese Children
Abstract Views :460 |
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Authors
Himani Kulshrestha
1,
Vani Gupta
1,
Sameeksha Mishra
1,
Supriya Mishra
1,
Shelly Awasthi
2,
Abbas Ali Mahdi
3
Affiliations
1 Department of Physiology, King George’s Medical University, Lucknow (U.P.), IN
2 Department of Paediatrics, King George Medical University, Lucknow (U.P.), IN
3 Department of Biochemistry, King George Medical University, Lucknow (U.P.), IN
1 Department of Physiology, King George’s Medical University, Lucknow (U.P.), IN
2 Department of Paediatrics, King George Medical University, Lucknow (U.P.), IN
3 Department of Biochemistry, King George Medical University, Lucknow (U.P.), IN
Source
International Journal of Medical Sciences, Vol 11, No 1-2 (2018), Pagination: 1-7Abstract
Background and aim: Anti-inflammatory IL-10, omentin-1 and inflammatory visfatin dysregulation play a role in the development of metabolic syndrome. The objective of this study was to evaluate the association between circulating IL-10, omentin-1 and visfatin concentration and risk of development of type II diabetesin obese with MS children.Methods:Total of 220 obese were enrolled in our case-control study. They were divided according to NCEP ATP III criteria into obese without MS (control) and obese with MS (case) based on their BMI-percentile, obese children subdivided into overweight, obese, severally obese on the basis of BMI (percentile). Fasting blood sample was collected to determine biochemical parameters. Serum IL-10, omentin-1and visfatin plasma level was assessed by ELISA kit method. Association of these proteins with biochemical and anthropometric parameters were studied. Results: Obese children with MS showed a borderline significant decrease in serum IL-10 levels, Omentin-1 levels however, significantly increased in visfatin levels as compared to without MS obese children. In correlation analysis, we found all the three proteins were significantly corelated with BMI (percentile) but visfatin was also corelated with fasting plasma glucose. Interpretation and conclusions: Our study supports the hypothesis that abnormal production of IL- 10, omentin-1 and visfatin may contribute to the development of obesity in children, the correlation between MS and the BMI (percentile) may be an effective parameter in identifying obese children and adolescents at risk for MS. Screening the cases with BMI (percentile) for MS is an important factor for establishing an early diagnosis of diabetes.Risk of development of MS may be a diagnostic parameter for obesity-related complications such as Type II DM.Keywords
Interleukin 10, Type II Diabetes Mellitus, HOMA-IR, Obesity, Omentin- 1, Visfatin.References
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