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Authors
Affiliations
1 Divisions of Pharmacology and Toxicology, SKUAST, R.S. Pura, Jammu, Jammu and Kashmir, IN
2 Veterinary Physiology, Faculty of Veterinary Sciences and Animal Husbandry,
SKUAST, R.S. Pura, Jammu, Jammu and Kashmir, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 17, No 2 (2010), Pagination: 82-85
Abstract
Molybdenum toxicity produces a state of secondary hypocuprosis, resulting into alterations in normal hematological profile. In the present study, ammonium molybdate alone and with copper sulfate (II) pentahydrate (ameliorative agent) was administered orally for 30 consecutive days in healthy goats of group 1 and 2, respectively, to access the effect on the hematological profile on different predetermined days of dosing. Administration of ammonium molybdate alone produced significant decline in the mean values of hemoglobin (Hb), packed cell volume (PCV), total leukocyte count (TLC), total erythrocyte count (TEC), and mean corpuscular hemoglobin concentration (MCHC), with a significant increase in neutrophil level and mean corpuscular volume (MCV). However, values of erythrocyte sedimentation rate, mean corpuscular hemoglobin, and differential leukocyte count were not significantly altered. On comparing observations of ameliorative group with the group 1 goats, it is concluded that the ameliorative copper salt has beneficial effects in alleviating the alterations in the values of Hb, PCV, TLC, TEC, MCV, MCHC, and neutrophils.
Keywords
Ammonium molybdate, copper sulfate, goats, hematological profile
