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Sood, Sushma
- An Update on Hazards and Management of Industrial Toxins
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Authors
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1 Pharmacology, PGIMS, Rohtak
2 Physiology, PGIMS, Rohtak
1 Pharmacology, PGIMS, Rohtak
2 Physiology, PGIMS, Rohtak
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Indian Journal of Forensic Medicine & Toxicology, Vol 7, No 1 (2013), Pagination: 234-239Abstract
A hazardous chemical is defined by the U.S. Occupational Safety and Health Administration as "any chemical that has been shown scientifically to be a health hazard (causes acute or chronic health effects) or a physical hazard (combustible liquid, explosive, flammable, etc.)". This federal agency estimates that there are about 5.7 lakhs chemicals in the workplace, with 50,000 being potentially hazardous. Considering that unplanned exposures and contamination that can occur at any time during manufacturing, transport, storage, usage, or disposal of these chemicals, inevitably, emergency physicians will, at some time, be responsible for the management and care of a hazardous materials patient. When managing a patient exposed to an industrial chemical, it is helpful to refer to the material safety data sheet. Here, specific physical and hazardous properties of a particular substance are described, including the risk for absorption after inhalation or dermal exposure, and the potential for systemic toxicity . But although the material safety data sheet will also include "first aid" recommendations, it is strongly recommended to consult with a medical toxicologist or a regional poison control center to discuss optimal, case-specific hazards, treatments, and dispositions. Some agents may result in delayed onset of symptoms that require at least 12 to 24 hours of monitoring. Also, contacting the regional poison control center facilitates accurate data collection and analysis of toxicologic exposures in the community.Keywords
Cholinergic Toxicity, Delayed Toxicity, Hydrocarbons, Pulmonary Edema, Respiratory Symptoms, Metabolic ToxicityReferences
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- An Update on Hazards and Management of Industrial Toxins
Abstract Views :453 |
PDF Views:0
Authors
Affiliations
1 Pharmacology 29 /9 J, PGIMS, Rohtak-124001, IN
2 Pharmacology, IN
3 Physiology, IN
4 Physiology, PGIMS, Rohtak
1 Pharmacology 29 /9 J, PGIMS, Rohtak-124001, IN
2 Pharmacology, IN
3 Physiology, IN
4 Physiology, PGIMS, Rohtak
Source
Indian Journal of Forensic Medicine & Toxicology, Vol 8, No 1 (2014), Pagination: 47-52Abstract
A hazardous chemical is defined by the U.S. Occupational Safety and Health Administration as "any chemical that has been shown scientifically to be a health hazard (causes acute or chronic health effects) or a physical hazard (combustible liquid, explosive, flammable, etc.)". This federal agency estimates that there are about 5.7 lakhs chemicals in the workplace, with 50,000 being potentially hazardous. Considering that unplanned exposures and contamination that can occur at any time during manufacturing, transport, storage, usage, or disposal of these chemicals, inevitably, emergency physicians will, at some time, be responsible for the management and care of a hazardous materials patient. When managing a patient exposed to an industrial chemical, it is helpful to refer to the material safety data sheet. Here, specific physical and hazardous properties of a particular substance are described, including the risk for absorption after inhalation or dermal exposure, and the potential for systemic toxicity . But although the material safety data sheet will also include "first aid" recommendations, it is strongly recommended to consult with a medical toxicologist or a regional poison control center to discuss optimal, case-specific hazards, treatments, and dispositions. Some agents may result in delayed onset of symptoms that require at least 12 to 24 hours of monitoring. Also, contacting the regional poison control center facilitates accurate data collection and analysis of toxicologic exposures in the community.Keywords
Cholinergic Toxicity, Delayed Toxicity, Hydrocarbons, Pulmonary Edema, Respiratory Symptoms, Metabolic Toxicity- To Study the Effect of Vitamin D and E on Sodium-Fluoride-induced Toxicity in Reproductive Functions of Male Rabbits
Abstract Views :132 |
PDF Views:0
Authors
Affiliations
1 Departments of Physiology, Pt B. D. Sharma PGIMS, Rohtak, Haryana, IN
2 Departments of Pathology, Pt B. D. Sharma PGIMS, Rohtak, Haryana, IN
3 Departments of Biochemistry, Pt B. D. Sharma PGIMS, Rohtak, Haryana, IN
1 Departments of Physiology, Pt B. D. Sharma PGIMS, Rohtak, Haryana, IN
2 Departments of Pathology, Pt B. D. Sharma PGIMS, Rohtak, Haryana, IN
3 Departments of Biochemistry, Pt B. D. Sharma PGIMS, Rohtak, Haryana, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 19, No 2 (2012), Pagination: 182-187Abstract
Objectives: Fluorosis is an endemic problem in many countries of world. This study was designed to see the effect of fluoride on the reproductive system and to see the role if any of vitamin D or E supplementation on it. Materials and Methods: Sixty rabbits were divided into six equal groups. Group I was fed on standard diet, Group II vehicle treated control, Group III on sodium fluoride (NaF) 20 mg/kg body weight, Group IV on NaF + Vitamin D, Group V on NaF + vitamin E, and Group VI on NaF + vitamin D + vitamin E. Results: In Group III (fed on sodium fluoride) significant decrease in sperm count (P<0.001), motility (P<0.001), progressive motility (P<0.01), and epididymal weight (P<0.05) compared to control was seen that was also evident on testicular histology. With vitamin D supplementation, there was a significant improvement in the sperm count (P<0.001), motility (P<0.01), and progressive motility (P<0.05) but remained significantly lower than the control values. With vitamin E supplementation there was significant improvement in the sperm count near normal. With vitamin D and E combined supplementation there was significant improvement in both sperm count and motility near to normal. Conclusions: We conclude that combined vitamin D and E treatment showed a significant improvement in reproductive functions affected by fluoride.Keywords
Fluoride, histology, rabbits, sperm, vitamin D, vitamin E- Study of Galvanic Skin Response in Patients of Moderate Depression
Abstract Views :249 |
PDF Views:1
Authors
Affiliations
1 Department of Physiology, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, IN
1 Department of Physiology, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, IN
Source
Indian Journal of Health and Wellbeing, Vol 10, No 1-3 (2019), Pagination: 29-31Abstract
With the rapid development the society the persons are having feelings o f sadness, loss, anger, or frustrations which interfere with everyday life for an extended period o f time resulting in the appearance o f various psychological problems, out o f which depression is most common having a prevalance o f 15.1% in India. Severe depression causes various physiological abnormalities leading to various co-morbid conditions. But there is very little literature available about moderate depression; hence the present study is designed to study the effect o f moderate depression on the autonomic system by galvanic skin response and cold pressor test. We studied 40 male patients (to avoid gender difference) o f moderate depression and 40 normal subjects of* same age group at rest in supine position (to avoid posture effect). Galvanic skin response was recorded and compared between these two groups. Comparison of*these two groups showed that GSR is not significantly different in moderate depression patients than that from the normal subjects. Though the major depression is associated with various co- morbid conditions but moderate depression hardly affects the autonomic system. Hence it is better to diagnose and treat the depression at moderate state.Keywords
Galvanic Skinresponse, Moderate Depression, Patients.References
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