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Sood, Sushma
- An Update on Hazards and Management of Industrial Toxins
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Authors
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1 Pharmacology, PGIMS, Rohtak
2 Physiology, PGIMS, Rohtak
1 Pharmacology, PGIMS, Rohtak
2 Physiology, PGIMS, Rohtak
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Indian Journal of Forensic Medicine & Toxicology, Vol 7, No 1 (2013), Pagination: 234-239Abstract
A hazardous chemical is defined by the U.S. Occupational Safety and Health Administration as "any chemical that has been shown scientifically to be a health hazard (causes acute or chronic health effects) or a physical hazard (combustible liquid, explosive, flammable, etc.)". This federal agency estimates that there are about 5.7 lakhs chemicals in the workplace, with 50,000 being potentially hazardous. Considering that unplanned exposures and contamination that can occur at any time during manufacturing, transport, storage, usage, or disposal of these chemicals, inevitably, emergency physicians will, at some time, be responsible for the management and care of a hazardous materials patient. When managing a patient exposed to an industrial chemical, it is helpful to refer to the material safety data sheet. Here, specific physical and hazardous properties of a particular substance are described, including the risk for absorption after inhalation or dermal exposure, and the potential for systemic toxicity . But although the material safety data sheet will also include "first aid" recommendations, it is strongly recommended to consult with a medical toxicologist or a regional poison control center to discuss optimal, case-specific hazards, treatments, and dispositions. Some agents may result in delayed onset of symptoms that require at least 12 to 24 hours of monitoring. Also, contacting the regional poison control center facilitates accurate data collection and analysis of toxicologic exposures in the community.Keywords
Cholinergic Toxicity, Delayed Toxicity, Hydrocarbons, Pulmonary Edema, Respiratory Symptoms, Metabolic Toxicity
References
- Rotenberg JS, Newmark J: Nerve agent attacks on children: diagnosis and management. Pediatrics2003; 112: 648.
- Henretig FM, Cieslak TJ, Eitzen EM: Biological and chemical terrorism. J Pediatr 2002; 141: 311.
- Committee on Environmental Health; Committee on Infectious Diseases, Michael WS, Julia AM: Chemical-biological terrorism and its impact on children. Pediatrics 2006; 118: 1267.
- Teran-Maciver M, Larson K: Implications of chemical biological terrorist events for children and pregnant women. MCN Am J Matern Child Nurs 2008; 33: 224.
- Borak J, Diller WF: Phosgene exposure: mechanisms of injury and treatment strategies. J Occup Environ Med 2001; 43: 110.
- Sciuto AM, Hurt HH: Therapeutic treatments of phosgene-induced lung injury. Inhal Toxicol 2004; 16: 565.
- Urbanetti JS: Toxic inhalational injury, in Sidell FR, Takafuji ET, Franz DR (eds): Medical Aspects of Chemical and Biological Warfare. Washington, DC, Office of the Surgeon General, 1997, p. 247– 270.
- Centers for Disease Control and Prevention (CDC): Ocular and respiratory illness associated with an indoor swimming pool—Nebraska, 2006. MMWR Morb Mortal Wkly Rep 2007; 56: 929.
- Babu RV, Cardenas V, Sharma G: Acute respiratory distress syndrome from chlorine inhalation during a swimming pool accident: a case report and review of the literature. J Intensive Care Med 2008; 23: 275.
- Vinsel PJ: Treatment of chlorine gas inhalation with nebulized sodium bicarbonate. J Emerg Med 1990; 8: 327.
- Sexton JD, Pronchik DJ: Chlorine inhalation: the big picture. J Toxicol Clin Toxicol 1998; 36: 87.
- Pavelchak N, Church L, Roerig S, et al: Silo gas exposure in New York State following the dry growing season of 1995. Appl Occup Environ Hyg 1999; 14: 34.
- Elsayed NM: Toxicity of nitrogen dioxide: an introduction. Toxicology 1994; 89: 161.
- Persinger RL, Poynter ME, Ckless K, Janssen- Heininger YM: Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lung. Mol Cell Biochem 2002; 234–235: 71.
- Pelham TW, Holt LE, Moss MA: Exposure to carbon monoxide and nitrogen dioxide in enclosed ice arenas. Occup Environ Med 2002; 59: 224.
- Aggarwal AN, Ramanathan RM, Jindal SK: Acute respiratory distress syndrome following nitrogen dioxide exposure. Indian J Chest Dis Allied Sci 1998; 40: 275.
- Hall AH, Rumack BH: Clinical toxicology of cyanide. Ann Emerg Med 1986; 15: 1067.
- Curry SC, Arnold-Capell P: Toxic effects of drugs used in the ICU: nitroprusside, nitroglycerin, and angiotensin-converting enzyme inhibitors. Crit Care Clin 1991; 7: 555.
- Cummings TF: The treatment of cyanide poisoning. Occup Med (Lond) 2004; 54: 82.
- Way JL: Cyanide intoxication and its mechanism of antagonism. Annu Rev Pharmacol Toxicol 1984; 24: 451.
- Chen KK, Rose CL, Clowes GH: Methylene blue, nitrites, and sodium thiosulfate against cyanide poisoning. Proc Soc Exp Biol Med 1933; 31: 250.
- Chen KK, Rose CL: Nitrite and thiosulfate therapy in cyanide poisoning. JAMA 1952; 149: 113.
- Gracia R, Shepherd G: Cyanide poisoning and its treatment. Pharmacotherapy 2004; 24: 1358.
- Baud FJ, Borron SW, Bavoux E, et al: Relation between plasma lactate and blood cyanide concentrations in acute cyanide poisoning. BMJ 1996; 312: 26.
- Baskin SI, Nealley EW, Lempka JC: Cyanide toxicity in mice pretreated with diethylamine nitric oxide complex. Hum Exp Toxicol 1996; 15: 13.
- Berlin CM: The treatment of cyanide poisoning in children. Pediatrics 1970; 46: 793.
- Kulig K: Cyanide antidotes and fire toxicology. N Engl J Med 1991; 325: 1801.
- Weiss LD, Van Meter KW: The applications of hyperbaric oxygen therapy in emergency medicine. Am J Emerg Med 1992; 10: 558.
- Tomaszewski CA, Thom SR: Use of hyperbaric oxygen in toxicology. Emerg Med Clin North Am 1994; 12: 437.
- Borron SW, Baud FJ, Megarbane B, Bismuth C: Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg Med 2007; 25: 551.
- Borron SW, Baud FJ, Barriot P, et al: Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg Med 2007; 49: 794.
- Gerasimon G, Bennett S, Musser J, Rinard J: Acute hydrogen sulfide poisoning in a dairy farmer. Clin Toxicol (Phil) 2007; 45: 420.
- An Update on Hazards and Management of Industrial Toxins
Abstract Views :453 |
PDF Views:0
Authors
Affiliations
1 Pharmacology 29 /9 J, PGIMS, Rohtak-124001, IN
2 Pharmacology, IN
3 Physiology, IN
4 Physiology, PGIMS, Rohtak
1 Pharmacology 29 /9 J, PGIMS, Rohtak-124001, IN
2 Pharmacology, IN
3 Physiology, IN
4 Physiology, PGIMS, Rohtak
Source
Indian Journal of Forensic Medicine & Toxicology, Vol 8, No 1 (2014), Pagination: 47-52Abstract
A hazardous chemical is defined by the U.S. Occupational Safety and Health Administration as "any chemical that has been shown scientifically to be a health hazard (causes acute or chronic health effects) or a physical hazard (combustible liquid, explosive, flammable, etc.)". This federal agency estimates that there are about 5.7 lakhs chemicals in the workplace, with 50,000 being potentially hazardous. Considering that unplanned exposures and contamination that can occur at any time during manufacturing, transport, storage, usage, or disposal of these chemicals, inevitably, emergency physicians will, at some time, be responsible for the management and care of a hazardous materials patient. When managing a patient exposed to an industrial chemical, it is helpful to refer to the material safety data sheet. Here, specific physical and hazardous properties of a particular substance are described, including the risk for absorption after inhalation or dermal exposure, and the potential for systemic toxicity . But although the material safety data sheet will also include "first aid" recommendations, it is strongly recommended to consult with a medical toxicologist or a regional poison control center to discuss optimal, case-specific hazards, treatments, and dispositions. Some agents may result in delayed onset of symptoms that require at least 12 to 24 hours of monitoring. Also, contacting the regional poison control center facilitates accurate data collection and analysis of toxicologic exposures in the community.Keywords
Cholinergic Toxicity, Delayed Toxicity, Hydrocarbons, Pulmonary Edema, Respiratory Symptoms, Metabolic Toxicity- To Study the Effect of Vitamin D and E on Sodium-Fluoride-induced Toxicity in Reproductive Functions of Male Rabbits
Abstract Views :135 |
PDF Views:0
Authors
Affiliations
1 Departments of Physiology, Pt B. D. Sharma PGIMS, Rohtak, Haryana, IN
2 Departments of Pathology, Pt B. D. Sharma PGIMS, Rohtak, Haryana, IN
3 Departments of Biochemistry, Pt B. D. Sharma PGIMS, Rohtak, Haryana, IN
1 Departments of Physiology, Pt B. D. Sharma PGIMS, Rohtak, Haryana, IN
2 Departments of Pathology, Pt B. D. Sharma PGIMS, Rohtak, Haryana, IN
3 Departments of Biochemistry, Pt B. D. Sharma PGIMS, Rohtak, Haryana, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 19, No 2 (2012), Pagination: 182-187Abstract
Objectives: Fluorosis is an endemic problem in many countries of world. This study was designed to see the effect of fluoride on the reproductive system and to see the role if any of vitamin D or E supplementation on it. Materials and Methods: Sixty rabbits were divided into six equal groups. Group I was fed on standard diet, Group II vehicle treated control, Group III on sodium fluoride (NaF) 20 mg/kg body weight, Group IV on NaF + Vitamin D, Group V on NaF + vitamin E, and Group VI on NaF + vitamin D + vitamin E. Results: In Group III (fed on sodium fluoride) significant decrease in sperm count (P<0.001), motility (P<0.001), progressive motility (P<0.01), and epididymal weight (P<0.05) compared to control was seen that was also evident on testicular histology. With vitamin D supplementation, there was a significant improvement in the sperm count (P<0.001), motility (P<0.01), and progressive motility (P<0.05) but remained significantly lower than the control values. With vitamin E supplementation there was significant improvement in the sperm count near normal. With vitamin D and E combined supplementation there was significant improvement in both sperm count and motility near to normal. Conclusions: We conclude that combined vitamin D and E treatment showed a significant improvement in reproductive functions affected by fluoride.Keywords
Fluoride, histology, rabbits, sperm, vitamin D, vitamin E- Study of Galvanic Skin Response in Patients of Moderate Depression
Abstract Views :255 |
PDF Views:1
Authors
Affiliations
1 Department of Physiology, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, IN
1 Department of Physiology, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, IN
Source
Indian Journal of Health and Wellbeing, Vol 10, No 1-3 (2019), Pagination: 29-31Abstract
With the rapid development the society the persons are having feelings o f sadness, loss, anger, or frustrations which interfere with everyday life for an extended period o f time resulting in the appearance o f various psychological problems, out o f which depression is most common having a prevalance o f 15.1% in India. Severe depression causes various physiological abnormalities leading to various co-morbid conditions. But there is very little literature available about moderate depression; hence the present study is designed to study the effect o f moderate depression on the autonomic system by galvanic skin response and cold pressor test. We studied 40 male patients (to avoid gender difference) o f moderate depression and 40 normal subjects of* same age group at rest in supine position (to avoid posture effect). Galvanic skin response was recorded and compared between these two groups. Comparison of*these two groups showed that GSR is not significantly different in moderate depression patients than that from the normal subjects. Though the major depression is associated with various co- morbid conditions but moderate depression hardly affects the autonomic system. Hence it is better to diagnose and treat the depression at moderate state.Keywords
Galvanic Skinresponse, Moderate Depression, Patients.References
- Abrams, S. (1973). The polygraph in a psychiatric setting. American Journal o f Psychiatry, 730(1), 94-98.
- Aramaki, S., Kira, Y., & Hirasawa, Y. (1997). A study of the normal values and habituation phenomenon of sympathetic skin response. American Journal o f Physical Medicine and Rehabilitation, 76(1), 2-7.
- Baba,M., Watahiki, Y.,Matsunaga,M., &Takebe, K. (1988). Sympathetic skin response in healthy man. Electroencephalography and Clinical Neurophysiology, 28, 277-283.
- Boettger, M.K., Greiner, W., Rachow, T., Bruhl, C., & Bar, KJ. (2010). Sympathetic skin response following painful electrical stimulation is increased in major depression. Epub, 740(1), 130-134.
- Drory, V.E., & Korczyn, A.D. (1993). Sympathetic skin response: Age effect. Neurology, 43(9), 1818-1820.
- Guinjoan, S.M., Bemabo, J.L., & Cardinali, D.P. (1995). Cardiovascular tests of autonomic function and sympathetic skin responses in patients with major depression. Journal o f Neurology, Neurosurgery, and Psychiatry, 58, 299-302.
- Hagbarth, K.E, Hallin, R.G, Hongell, A., Thorebjork, H.E, & Wallin, B.G. (1972). General characteristics of sympathetic activity in human skin nerves. Acta Physiologica Scandinavica, 84(2), 164-176.
- ICD-10 Classification ofmental & behavioural disorder (2007). Clinical descriptions and diagnostic guidelines. Indian ed. Delhi: A.I.T.B.S. Publishers, p. 110-11.
- Jung, C.G. (1907). On the psychophysical relations of the association experiment. Journal o f Abnormal Psychology, 7(6), 247-255.
- Lin, T., Omata, M., Hu, W., & Imamiya, A. (2005). Do physiological data relate to traditional usability indexes? Proceedings of OZCHI. ACM Press, p. 1-10.
- Levy, D.M., Reid, G., Rowley, D.A.,& Abraham, R.R. (1992). Quantitative measures of sympathetic skin response in diabetes: Relation to pseudomotor and neurological function. Journal o f Neurology, Neurosurgery, and Psychiatry, 55(10), 902-908.
- Moore, M.M., & Dua, U. (2004). Galvanic skin response interfacefor people -with severe motor disabilities, accessibility and computing. Proceeding of the 6th international ACM SIGACCESS conference on Computer and accessibility. Atlanta, USA. 48-54.
- Solders, G. (1986). Autonomic function tests in healthy controls and in terminal uraemia. ActaNeurologicaScandinavica, 73, 638-639.
- Shi, Y., Choi, E.H.C., Ruiz, N., Chen, F., & Taib, R. (2007). Galvanic skin response (GSR) as an index o f cognitive workload. ACM CHI Conference Work-in-progress.