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Authors
Affiliations
1 Government College of Pharmacy, Vidyanagar, Karad (MS), IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 7 (2011), Pagination: 1119-1124
Abstract
A versatile, accurate, precise and economic method for simultaneous determination of Domperidone and Omeprazole in fixed dose combination products was developed. The absorbance values at 284.8 nm and 301.2 nm and 290.9nm (isoabsorptive point) were used for the estimation of Domperidone and Omeprazole, respectively without mutual interference. This method obeyed Beer's law in the concentration range of 18-28 μg /ml for Domperidone and 5-30 μg/ml for Omeprazole. The results of analyses have been validated statistically for linearity, accuracy and precision, LOD and LOQ of the proposed method.
Keywords
Domperidone, Omeprazole, Dimetyl Formamide, Distilled Water, Ultraviolet Spectrophotometry.
