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Authors
Affiliations
1 Department of Veterinary Physiology
Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141 004, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 16, No 1 (2009), Pagination: 73-76
Abstract
Endotoxic shock was produced in five apparently healthy male buffalo calves aged between 4 months to 1 year by I/v infusion of E.coli endotoxin @ 5 μg/Kg BW/ hour for 3 hours. The animals were further observed for a period of 7 days. A general hypoproteinemia was observed during endotoxin infusion along with significant (P<0.01) hypoalbuminemia, hypoglycemia, decrease in plasma globulin, creatinine, BUN and chloride while plasma sodium, potassium, showed nonsignificant alterations during endotoxin infusion for 3 hours. All the endotoxemic buffalo calves were infused I/v hypertonic saline solution (7.2% NaCl acq.) @ 4ml/Kg BW in 6.5 minutes followed by dexamethasone @ 4mg/Kg BW and flunixin meglumine @ 1.1 mg/Kg BW as one time infusion and plasma proteins showed a significant decrease at 4, 5 and 6 hour and on day 2 and 3while albumin showed a declining trend throughout the observation period with a significant fall at 3, 4, 5 hour and on day 6 of start of endotoxin infusion. Plasma globulin and other proteins also decreased. Plasma fibrin increased significantly at 6th hour to day 7 i.e., end of the observation period. Hypoglycemia continued from 2nd to 6th hour followed by day 1-5 accompanied by a significant fall in BUN on day 1-3. The plasma creatinine along with sodium and potassium did not alter significantly.
Keywords
Biochemistry, Endotoxemia, Hypertonic saline, Dexamethasone, Flunixin meglumine, Buffalo calves
