Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Sundari, Shantha
- Quantitative Changes of Red Blood cells in Cancer Patients under Palliative Radiotherapy-A Retrospective Study
Abstract Views :158 |
PDF Views:0
Authors
Affiliations
1 Department of Pathology, Saveetha Institute of Medical And Technical Science, Saveetha University, Chennai, IN
2 Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, IN
3 Department of Orthodontics, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, IN
1 Department of Pathology, Saveetha Institute of Medical And Technical Science, Saveetha University, Chennai, IN
2 Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, IN
3 Department of Orthodontics, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 2 (2019), Pagination: 687-692Abstract
Introduction: Radiation can be defined as an emission of energy. Radiations like X-rays, gamma rays, and charged particles are used for cancer treatment. Radiation therapy inhibits the ability of the cancer cells to grow and divide, thus slowing their growth and killing them. Radiation therapy is given in curative or palliative intents. Palliative treatments are not intended to cure. They are given to the patients with advanced stage of cancers to reduce the symptoms and suffering caused by cancer. Exposure to ionizing radiation can cause changes in normal blood cell nature. Anemia is a common complication of myelosuppressive chemotherapy. These types of anemia are treated with repeated blood transfusions. The reduction in the leucocyte count is treated with Colony Stimulating Factors. Materials and Methods: Thirty-two cancer positive patients who underwent palliative radiotherapy for five fractions were included in this study. Complete blood count reports were collected from the clinical lab. RBC count of the sample population was noted and compared before and after radiotherapy. Results were analyzed statistically. Results: Results of the comparison between the RBC counts before and after the first fraction of the radiotherapy showed that there was no significant change. As the fractions of radiotherapy increased the RBC count showed a significant reduction which was statistically also significant. Males showed an RBC count reduction after the completion of radiotherapy than the females. Conclusion: In conclusion, a routine serial blood count determination during the entire course of palliative radiation showed a significant effect on RBC count. Though the advanced radiotherapy technologies were followed, the effect of radiation in the human body is still continuing at a lower level and insists the radiotherapist that a follow-up blood examinations is must for all the cancer patients who are under chemotherapy or radiotherapy.Keywords
Palliative, Radiotherapy, RBC Count, Anemia, Cancer.
References
- World Health Organization. Cancer Fact sheet N°297". February 2014.10 June 2014.
- National Cancer Institute. Defining Cancer. 10 June 2014. p34.
- Lawrence TS, Ten Haken RK. Principles of Radiation Oncology. Philadelphia; Cancer- American cancer society, 2008, Volume 17, 8th edition, p67-p70
- Blank KR. Once-Weekly Dosing of Epoetin- Increases Haemoglobin and Improves Quality of Life in Anemic Cancer Patients Receiving Radiation Therapy Either Concomitantly or Sequentially with Chemotherapy. International Journal of Radiation Oncology and Biological Physics. 1997, 44(4), p317-321
- Yang FE. Combined therapy for cancer of the anal canal: a preliminary report. International journal of radiation oncology and biological physics. 1995; 33(5); 607-617.
- Groopman JE, Itri LM. Chemotherapy-induced anemia in adults: incidence and treatment.J Natl Cancer Inst.1999; 91: 1616–1634.
- Effects of Ionising Radiation on Blood and Blood Components: A Survey. International atomic energy agency.1997, IAEA-TECDOC-934, ISSN 1011-4289.
- M. E. Gaulden. Biological Dosimetry of Radionuclide and Radiation Hazards. Journal of Nuclear Medicine, 1983 vol 24; issue 2, pp. 160-164.
- Finkelstein SE, Fishman M. Clinical opportunities in combining immunotherapy with radiation therapy. Front Oncol 2012; 2:169.
- M. Anderson, S. J. Marsden, E. G. Wright, M. A. Kadhim, T. Goodhead and C. S. Griffin. Complex Chromosome aberrations in Peripheral Blood Lymphocytes as a Potential biomarker of Exposure to High-LET Alpha-Particles. International Journal of Radiation Biology, 2000, Vol. 76(2), pp. 31-42.
- R. J. Dufrain, L. G. Littlefield and E. E. Joiner, Human Cytogenetic Dosimetry: A Dose Response Relationship for Alpha Particle Radiation. Health Physics, Vol. 37, No. 3, 1979, pp. 279-289.
- National Research Council of the National Academy. Health Risks from Exposure to Low Levels of Ionising Radiation, Beir VII Phase 2, 2006.
- R. W. Field. Radon: An Overview of Health Effects. Encyclopedia of Environmental Health, 2011 vol 23, issue 7 pp. 745-753.
- H. Ismail and M. S. Jaafar, Interaction of Low-Intensity nuclear Radiation Dose with the Human Blood: Using the new Technique of CR-39NTDs for an in Vitro Study. Applied radiation and Isotopes,2011, Vol. 69, No. 3, pp. 559-566.
- Finkelstein SE, Fishman M. Clinical opportunities in combining immunotherapy with radiation therapy. Front Oncol 2010, vol 2(2), 169.
- Vanneman M, Dranoff G. Combining immunotherapy and targeted therapies in cancer treatment. Nat Rev Cancer, vol 12(12), p237-251.
- Van Nostrand D, Freiats J. Side effects of I-131 for ablation and treatment of well-differentiated thyroid carcinoma. NJ: humana press, 2006, 89(6), p454.
- Li W, Li ZY, Mao YX, Zhang YT, Zhao YM, Chen K; Inhibition of MCF-7 breast cancer cellinduced platelet aggregation using a combination of antiplatelet drugs. Oncol Lett,2013, vol 3, issue(5) p675-680.
- Kolb HJ; Bone marrow morbidity of radiotherapy, in Plowman PN, McElwain T, Meadows A. Complications of Cancer Management- Oxford 1991, 65(7), p 398.
- Camerer E, Qazi AA, Duong DN, Cornelissen I, Advincula R and Coughlin SR; Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood; volume 104, issue 004, p397-401.
- Connell MJ, Martenson JA, Wieand HS, Krook JE, Macdonald JS, Haller DG, Mayer RJ, Gunderson LL, Rich TA. Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med 1994, volume 331 issue 9, page 502
- Hank B, Cohen AM, Kelsen DP: Cancer of the anal region; Principles and Practice of Oncology. 1989, volume 12 issue 8; page765.
- Sri Vasavi kadiyala. Platelet count in cancer patients under radiation therapy. Int J.Pharm.Sci. 2018, vol 48 issue 1 p52-p53.
- Maria da salete fonseca. Weekly monitoring the effects of conventional external beam radiation therapy by means of blood cells count- leukocyte and platelet. Radiologia Brasileira. 2008, volume 41, issue 1, p5509-5512.
- Friedrich H.Stutz. Local radiotherapy and peripheral white blood cell count: a review of 203 treatment records. Military medicine, volume 141, issue 6, p390-p391.
- Marguerite P.Skyes. Long term effects of therapeutic irradiation upon bone marrow. ORCID. Volume 17, issue 9, p1144-p1150.
- Skyes. H. blood lymphocytes after radiation therapy of mammary carcinoma. Acta radiologica therapy physics biology.1974, Volume 13, issue 3, 185-200.